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3,6-Dichloropyrazine-2-carbonitrile
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3,6-Dichloropyrazine-2-carbonitrile
Artikel-Nr:
(PRSI7507)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
7507
Lokale Artikelnummer::
PRSI7507
Beschreibung:
IL-36B is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL-36B is thought to activate the NF-kappaB pathway through IL-1 receptor family members IL-1RL2 and IL-1RAcP. Like the related proteins IL-36A and IL-36G, IL-36B requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown. The IL-36 cytokines have been suggested to amplify Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells.
VE:
1 * 100 µG
Artikel-Nr:
(114-8395)
Lieferant:
ATLAS - the shoe company
Hersteller-Artikelnummer::
89200_36
Lokale Artikelnummer::
ATLA89200_36
Beschreibung:
ESD-Sicherheitsschuh aus weichem, vollnarbigem Rindsleder und einer rutschhemmenden, antistatischen Sneaker-Sohle (3,0 mm Profil, öl-, säure- und hitzebeständig).
VE:
1 * 1 PAAR
Artikel-Nr:
(SIAL674044-1L)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
674044-1L
Lokale Artikelnummer::
SIAL674044-1L
Beschreibung:
Poly(methacrylic acid, sodium salt) solution, M.W. 4000 - 6000 40% (w/w) in Wasser, Sigma-Aldrich®
VE:
1 * 1 L
Artikel-Nr:
(114-4684)
Lieferant:
ATLAS - the shoe company
Hersteller-Artikelnummer::
82436
Lokale Artikelnummer::
ATLA82436
Beschreibung:
ESD-Schuhe aus Waterproof-Leder mit Sicherheitsreflektoren und einer MPU® Light Laufsohle (3,5 mm Profil, öl-, säure-, kraftstoffbeständig; antistatisch).
VE:
1 * 1 PAAR
Artikel-Nr:
(MOLE20889868-25G)
Lieferant:
Molekula
Hersteller-Artikelnummer::
20889868-25G
Lokale Artikelnummer::
MOLE20889868-25G
Beschreibung:
N-Decyl-N,N-dimethyl-3-ammonio-1-propansulfonat (Sulfobetain-10, SB-10)
VE:
1 * 25 g
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(PRSI3119)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3119
Lokale Artikelnummer::
PRSI3119
Beschreibung:
ATR Antibody: The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI3117)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3117
Lokale Artikelnummer::
PRSI3117
Beschreibung:
ATR Antibody: The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI33-895)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-895
Lokale Artikelnummer::
PRSI33-895
Beschreibung:
Recognises a protein of 36 kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
VE:
1 * 100 µG
New Product
Lieferant:
MP Biomedicals
Beschreibung:
Soluble in acetone and in methanol (5 mg/ml) yielding a clear to very slightly hazy, yellow to amber solution. Gossypol is insoluble in water, very slightly soluble in petroleum ether and soluble in ethanol, ether, chloroform and DMF. It is freely soluble (with slow decomposition) in dilute aqueous solutions of ammonia and sodium carbonate.
Lieferant:
Sigma-Aldrich
Beschreibung:
Isonicotinsäure, Sigma-Aldrich®
Artikel-Nr:
(APPC141952.1211)
Lieferant:
APPLICHEM
Hersteller-Artikelnummer::
141952.1211
Lokale Artikelnummer::
APPC141952.1211
Beschreibung:
EDTA-Tetranatriumsalz-Tetrahydrat ≥98%, rein
VE:
1 * 1.000 g
Lieferant:
Sigma-Aldrich
Beschreibung:
Methyl-β-cyclodextrin is a macrocyclic compound that can form inclusion complexes with a number of guest molecules. It shows higher solubility in aqueous solutions and greater solubilising and complexing power compared to the parent β-cyclodextrin.
Artikel-Nr:
(BOSSBS-12972R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12972R-CY3
Lokale Artikelnummer::
BOSSBS-12972R-CY3
Beschreibung:
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12972R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12972R-HRP
Lokale Artikelnummer::
BOSSBS-12972R-HRP
Beschreibung:
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0267R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0267R-CY7
Lokale Artikelnummer::
BOSSBS-0267R-CY7
Beschreibung:
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5566R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5566R-CY3
Lokale Artikelnummer::
BOSSBS-5566R-CY3
Beschreibung:
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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