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(4-Chlor-3-(trifluormethyl)phenyl)essigsäure
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(4-Chlor-3-(trifluormethyl)phenyl)essigsäure
Artikel-Nr:
(BOSSBS-0653R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0653R-CY5.5
Lokale Artikelnummer::
BOSSBS-0653R-CY5.5
Beschreibung:
Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9450R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9450R-CY7
Lokale Artikelnummer::
BOSSBS-9450R-CY7
Beschreibung:
Cytidine is a nucleoside formed by a cytosine attached to a ribose ring via a beta-N1-glycosidic bond. DNA is methylated on cytidines by DNA methylases (DNMTs)to generate 5-methylcytidine (5-mC), a potent epigenetics marker and regulator of gene expression. The reverse reaction (cytidine demethylation) starts with its oxidation to hydroxymethyl- (5-hmC), formyl- (5-fC), and carboxy- (5-caC) cytidine. Several enzymes, including the Tet family of proteins have been implicated in cytidine demethylation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0626R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0626R
Lokale Artikelnummer::
BOSSBS-0626R
Beschreibung:
Anti-ZNF268 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10428R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10428R-A647
Lokale Artikelnummer::
BOSSBS-10428R-A647
Beschreibung:
Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11797R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11797R-FITC
Lokale Artikelnummer::
BOSSBS-11797R-FITC
Beschreibung:
Aldehyde dehydrogenases (ALDHs) mediate the NADP+-dependent oxidation of aldehydes into acids and play an important role in the detoxification of alcohol-derived acetaldehyde, as well as in lipid peroxidation and in the metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH3A2 (aldehyde dehydrogenase 3 family, member A2), also known as SLS, FALDH or ALDH10, is a 485 amino acid single-pass membrane protein that localizes to the cytoplasmic side of the endoplasmic reticulum and belongs to the aldehyde dehydrogenase family. Expressed in a variety of tissues, including liver, heart, lung, brain, kidney and placenta, ALDH3A2 catalyzes the NAD+-dependent oxidation of long-chain aliphatic aldehydes to fatty acids, a process that is necessary for detoxification and lipid metabolism. Defects in the gene encoding ALDH3A2 are the cause of Sjoegren-Larsson syndrome (SLS), an autosomal recessive neurocutaneous disorder characterized by severe mental retardation, seizures and speech defects. Multiple isoforms of ALDH3A2 exist due to alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6126R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6126R-CY5
Lokale Artikelnummer::
BOSSBS-6126R-CY5
Beschreibung:
The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5135R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5135R-HRP
Lokale Artikelnummer::
BOSSBS-5135R-HRP
Beschreibung:
CREM is a a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is derived from a multiexonic gene that encodes both activators and antagonists of cAMP-inducible transcription by differential splicing. Splice variants with antagonistic function lack 2 glutamine-rich domains and block cAMP-induced transcription, whereas an isoform that includes these glutamine-rich domains is a transcriptional activator.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13700R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13700R-CY3
Lokale Artikelnummer::
BOSSBS-13700R-CY3
Beschreibung:
SH3BGRL2
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3158R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3158R-A555
Lokale Artikelnummer::
BOSSBS-3158R-A555
Beschreibung:
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4755R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4755R-A647
Lokale Artikelnummer::
BOSSBS-4755R-A647
Beschreibung:
Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5988R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5988R
Lokale Artikelnummer::
BOSSBS-5988R
Beschreibung:
This gene encodes a member of the ALEX family of proteins and may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and two Armadillo (arm) repeats. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members, including ALEX2 and ALEX3, on the X chromosome. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15006R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15006R-FITC
Lokale Artikelnummer::
BOSSBS-15006R-FITC
Beschreibung:
Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf110 gene product has been provisionally designated C1orf110 pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8396R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8396R-HRP
Lokale Artikelnummer::
BOSSBS-8396R-HRP
Beschreibung:
FBXO15, also known as FBX15, is a 434 amino acid protein that contains one C-terminal F-box domain and belongs to the F-box family of proteins. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-a and b-catenin, for degradation by the proteasome after ubiquitination. Via its F-box domain, FBXO15 can directly interact with Skp1 p19 and CUL-1. In addition, FBXO15 is a target of the transcription factor Oct-3/4, however, it does not appear to be essential for early development and fertility.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3148R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3148R-A488
Lokale Artikelnummer::
BOSSBS-3148R-A488
Beschreibung:
Glycogen synthase kinase 3 (GSK3) is a proline directed serine threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase. GSK3 has been implicated in fundamental cell processes such as cell fate determination, metabolism, transcriptional control and oncogenesis. Two isoforms, alpha (GSK3A; OMIM 606784) and beta, show a high degree of amino acid homology within their catalytic domains. GSK3B is involved in energy metabolism, neuronal cell development and body pattern formation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0260R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0260R-A750
Lokale Artikelnummer::
BOSSBS-0260R-A750
Beschreibung:
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognise different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1322R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1322R-A680
Lokale Artikelnummer::
BOSSBS-1322R-A680
Beschreibung:
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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