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3-Aminopiperidine+hydrochloride,+N1-CBZ+protected
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3-Aminopiperidine+hydrochloride,+N1-CBZ+protected
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Interleukin 36 gamma (IL-36 ɣ) is a member of the interleukin 1 (IL-1) cytokine family and protects against pathogens in the skin, lung, and stomach epithelial barriers. IL-36 ɣ binds the interleukin-1 receptor accessory protein (IL-1RAcP) and the orphan IL-1R-related protein 2 (IL-1Rrp2) receptors to activate NF-kB and MAP kinase signaling pathways, resulting in the induced production of inflammatory cytokines and chemokines.
Artikel-Nr:
(PRSI27-304)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
27-304
Lokale Artikelnummer::
PRSI27-304
Beschreibung:
TERF2 is a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
VE:
1 * 100 µG
Lieferant:
Biotium
Beschreibung:
This monoclonal antibody is part of a new panel of reagents, which recognizes subcellular organelles or compartments of human cells. These markers may be useful in identification of these organelles in cells, tissues, and biochemical preparations. This MAb recognizes the double stranded DNA in human cells. It can be used to stain the nuclei in cell or tissue preparations and can be used as a nuclear marker in human cells. This MAb produces a homogeneous staining pattern in the nucleus of normal and malignant cells.,Deoxyribonucleic acid (DNA) is a long polymer of nucleotides that is held together by a backbone made of sugars and phosphate groups. It holds the genetic instructions for the development and function of living things. DNA is crucial for living organisms, and all known cellular life and some viruses contain DNA. In eukaryotes, DNA exists in the cell nucleus, while in prokaryotes; DNA is located in the cytoplasm. In living organisms, DNA does not usually exist as a single molecule, but instead as a tightly associated pair of molecules in the shape of a right-handed double helix. Hydrogen bonds as well as forces generated by the hydrophobic effect and pi stacking hold the two DNA strands together. During replication and transcription, portions of the helix unwind and become single stranded. Protective proteins surround these single-stranded DNA. Double stranded (ds) DNA markers are useful tools in biology research and aid in the study of DNA behavior and characteristics.
Lieferant:
Biotium
Beschreibung:
This monoclonal antibody is part of a new panel of reagents, which recognizes subcellular organelles or compartments of human cells. These markers may be useful in identification of these organelles in cells, tissues, and biochemical preparations. This MAb recognizes the double stranded DNA in human cells. It can be used to stain the nuclei in cell or tissue preparations and can be used as a nuclear marker in human cells. This MAb produces a homogeneous staining pattern in the nucleus of normal and malignant cells.,Deoxyribonucleic acid (DNA) is a long polymer of nucleotides that is held together by a backbone made of sugars and phosphate groups. It holds the genetic instructions for the development and function of living things. DNA is crucial for living organisms, and all known cellular life and some viruses contain DNA. In eukaryotes, DNA exists in the cell nucleus, while in prokaryotes; DNA is located in the cytoplasm. In living organisms, DNA does not usually exist as a single molecule, but instead as a tightly associated pair of molecules in the shape of a right-handed double helix. Hydrogen bonds as well as forces generated by the hydrophobic effect and pi stacking hold the two DNA strands together. During replication and transcription, portions of the helix unwind and become single stranded. Protective proteins surround these single-stranded DNA. Double stranded (ds) DNA markers are useful tools in biology research and aid in the study of DNA behavior and characteristics.
Lieferant:
Biotium
Beschreibung:
This monoclonal antibody is part of a new panel of reagents, which recognizes subcellular organelles or compartments of human cells. These markers may be useful in identification of these organelles in cells, tissues, and biochemical preparations. This MAb recognizes the double stranded DNA in human cells. It can be used to stain the nuclei in cell or tissue preparations and can be used as a nuclear marker in human cells. This MAb produces a homogeneous staining pattern in the nucleus of normal and malignant cells.,Deoxyribonucleic acid (DNA) is a long polymer of nucleotides that is held together by a backbone made of sugars and phosphate groups. It holds the genetic instructions for the development and function of living things. DNA is crucial for living organisms, and all known cellular life and some viruses contain DNA. In eukaryotes, DNA exists in the cell nucleus, while in prokaryotes; DNA is located in the cytoplasm. In living organisms, DNA does not usually exist as a single molecule, but instead as a tightly associated pair of molecules in the shape of a right-handed double helix. Hydrogen bonds as well as forces generated by the hydrophobic effect and pi stacking hold the two DNA strands together. During replication and transcription, portions of the helix unwind and become single stranded. Protective proteins surround these single-stranded DNA. Double stranded (ds) DNA markers are useful tools in biology research and aid in the study of DNA behavior and characteristics.
Lieferant:
Sartorius
Beschreibung:
Sartopore® 2 XLM is designed with finer filter membranes (0,1 µm) for the successful retention of Mycoplasma. The build in 0,2 µm prefilter layer is specifically designed to protect the final 0,1 μm membrane layer in cell culture media filtration applications.
Lieferant:
UVEX
Beschreibung:
Die Super OTG verfügt über scharnierlose Bügel aus Grilamid. Sie vereint die Vorteile der Bügelbrille mit den Trageeigenschaften von Kopfbändern.
Lieferant:
LABCON
Beschreibung:
ProtectR® tube is the only container closure system engineered to be CO₂ resistant and stop costly damage to molecular and cellular solutions when using dry ice. Made of durable, high-quality materials and fitted with an air-tight cap, ProtectR® Tubes form a protective barrier impermeable to CO₂, keeping the sample pH stable and preventing acidification.
Lieferant:
3M
Beschreibung:
3M™ Allzweckklebebänder aus Vinyl und mit einem Gummikleber beschichtet. Man verwendet sie für unkritische Anwendungen wie Farbkodierungen, Bündel- und Sicherheitsmarkierung, temporäre Markierung von Teilen und Maschinen, zum Schutz von Teilen und Ausrüstung oder zum Schutz vor Abnutzung.
Lieferant:
Thermo Scientific
Beschreibung:
N-Boc-ethylendiamin
Lieferant:
Showa
Beschreibung:
These powder-free disposable gloves are made from 100% nitrile. They provide protection against the penetration and projection of chemicals.
Artikel-Nr:
(AKAAAK-260)
Lieferant:
AK
Hersteller-Artikelnummer::
AK-260
Lokale Artikelnummer::
AKAAAK-260
Beschreibung:
Klarer Plastikspender mit nach oben zu öffnendem Klappdeckel zur Verwendung in Lebensmittel- und medizinischen Bereichen.
VE:
1 * 1 ST
Lieferant:
SIOEN PERSONAL PROTECTIVE CLOT
Beschreibung:
Schützende, zweifarbige Jacke aus 100 % weichem, doppelseitigem Polyester-Fleece für einen guten Schutz vor Kälte. Mit Antipilling-Behandlung und Saumnähten. Kann mit einem Reißverschluss in die Regenjacke 608Z eingesetzt werden.
Artikel-Nr:
(113-0408)
Lieferant:
International Enviroguard
Hersteller-Artikelnummer::
V3100-3XL
Lokale Artikelnummer::
IENVV3100-3XL
Beschreibung:
Diese rutschhemmenden Überschuhe aus Polypropylen-Spinnvlies können zum Schutz vor Schmutz, Öl und Partikel in ungefährlichen Umgebungen eingesetzt werden.
VE:
1 * 300 ST
Artikel-Nr:
(BOSSBS-5650R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5650R-CY3
Lokale Artikelnummer::
BOSSBS-5650R-CY3
Beschreibung:
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5130R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5130R-FITC
Lokale Artikelnummer::
BOSSBS-5130R-FITC
Beschreibung:
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D. Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect machanism. Interacts with CRY1 and CRY2; negatively regulates CRY1 phosphorylation.
VE:
1 * 100 µl
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noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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