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3-Aminopiperidine+hydrochloride,+N1-CBZ+protected
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3-Aminopiperidine+hydrochloride,+N1-CBZ+protected
Artikel-Nr:
(BOSSBS-2907R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2907R-A555
Lokale Artikelnummer::
BOSSBS-2907R-A555
Beschreibung:
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2908R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2908R-A680
Lokale Artikelnummer::
BOSSBS-2908R-A680
Beschreibung:
Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganisation of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA, HSF1, HSP27/HSPB1, KRT18, KRT2, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA, PABPC1 and TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilisation: following DNA damage, relocalises from nucleus to cytoplasm and phosphorylates HNRNPA and PARN, leading to stabilise GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5150R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5150R-CY7
Lokale Artikelnummer::
BOSSBS-5150R-CY7
Beschreibung:
Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5150R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5150R-CY3
Lokale Artikelnummer::
BOSSBS-5150R-CY3
Beschreibung:
Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs).
VE:
1 * 100 µl
Lieferant:
SIOEN PERSONAL PROTECTIVE CLOT
Beschreibung:
Winddichter, atmungsaktiver Thermoweste aus Siopor® FR AST-Gewebe (100% Polyestergewebe mit 100% FR PU-Beschichtung + AST). Mit fest verstepptem, flammhemmendem Baumwollfutter und abgesteppten Nähten. Bietet guten Schutz vor Kälte, Regen, Wind und Flammen.
Lieferant:
GA
Beschreibung:
Transparent cryogenic self-laminating labels for thermal transfer printers. Their clear laminate protects the printed information from alcohols and detergents to ensure the secure identification of tubes and cryo vials. These labels will also withstand prolonged storage under cryogenic conditions, including in liquid phase and vapor phase liquid nitrogen.
Lieferant:
SIOEN PERSONAL PROTECTIVE CLOT
Beschreibung:
Dieser ungefütterte Overall besteht aus Chemtex®, einem doppelseitig PVC-beschichteten Polyesterstoff. Er schützt vor Chemikalien, Ölen und Fetten.
Artikel-Nr:
(DOWC25100445)
Lieferant:
DOW CORNING
Hersteller-Artikelnummer::
25100445
Lokale Artikelnummer::
DOWC25100445
Beschreibung:
Dow silicone 10 to 1 encapsulants are supplied as two-part liquid component kits. When liquid components are thoroughly mixed, the mixture cures to a flexible elastomer, which is well suited for the protection of electrical/PCB system assembly applications. Dow silicone encapsulants cure without exotherm at a constant rate regardless of sectional thickness or degree of confinement.
VE:
1 * 1,1 kg
Lieferant:
Deb-STOKO
Beschreibung:
Vielseitige Hautcreme (O/W-Emulsion) zum Schutz für empfindliche Haut, die wechselnden und unterschiedlichen Belastungen ausgesetzt ist. Auch unter Handschuhen anwendbar. Das Produkt schützt sowohl gegen rein ölige als auch wassermischbare oder wässrige Arbeitsstoffe. Ideal für Aktivitäten in verschiedenen Arbeitsbereichen.
Artikel-Nr:
(111-2170)
Lieferant:
DRAEGER
Hersteller-Artikelnummer::
R59431
Lokale Artikelnummer::
DRAER59431
Beschreibung:
Diese kombinierte Brand- und Industriefluchthaube wurde gemeinsam mit Anwendern und im Hinblick auf eine möglichst schnelle Flucht entwickelt. Der optimierte Bedien- und Tragekomfort, das stabile Gehäuse und der geprüfte ABEK P3 Filter schützen mindestens 15 Minuten vor toxischen Industriegasen, Dämpfen und Partikeln.
VE:
1 * 1 ST
Lieferant:
AMMERFLON
Beschreibung:
PTFE, weiß zum Abdichten von Gewinden. Stärke 0,1 mm. Rolle mit Schutzdeckel zur sauberen Aufbewahrung.
Artikel-Nr:
(113-0032)
Lieferant:
AK
Hersteller-Artikelnummer::
AK-1479
Lokale Artikelnummer::
AKAAAK-1479
Beschreibung:
Acryl-Spender für Handschuhe, Hauben, Haarnetze und Überschuhe.
VE:
1 * 1 ST
Lieferant:
HULME MARTIN HEAT SEALERS
Beschreibung:
Superseal Impulse heat sealers are suitable for a wide range of laboratory and medical applications. Units are used extensively for the protective packaging, storage and distribution of pharmaceutical products, chemicals, and many other materials. They are also used for the safe containment and transfer of blood specimens, medical waste and other potentially hazardous substances.
Lieferant:
COMBI-BLOCKS
Beschreibung:
1-Boc-4-piperidon
Lieferant:
COMBI-BLOCKS
Beschreibung:
(S)-(+)-1-Boc-3-hydroxypyrrolidin
Lieferant:
CENTURION SAFETY PRODUCTS
Beschreibung:
Der Concept Roofer ist ein leichter, strapazierfähiger und bequemer Helm aus ABS.
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
Dieses Produkt wurde von Ihrer Organisation gesperrt. Bitte kontaktieren Sie Ihren Einkauf für weitere Informationen.
Dieses Produkt ist Ersatz für den von Ihnen gewünschten Artikel.
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