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4,4\\\\\\\'-Methylenebis(2-methylcyclohexylamine)+(mixture+of+iso
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4,4\\\\\\\'-Methylenebis(2-methylcyclohexylamine)+(mixture+of+iso
Artikel-Nr:
(BOSSBS-15187R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15187R-A488
Lokale Artikelnummer::
BOSSBS-15187R-A488
Beschreibung:
C4orf17 (chromosome 4 open reading frame 17) is a 359 amino acid protein encoded by a gene that maps to human chromosome 4. Human chromosome 4 represents approximately 6% of the human genome and contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington's disease, is on chromosome 4. FGFR-3 is also encoded by a gene that is located on chromosome 4, and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8017R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8017R-FITC
Lokale Artikelnummer::
BOSSBS-8017R-FITC
Beschreibung:
CLN6, a 311 amino acid protein, has seven predicted transmembrane domains and is conserved across vertebrates. The CLN6 protein localizes to the endoplasmic reticulum but contributes to lysosomal function. Mutations in the CLN6 gene cause variant late-onset infantile neuronal ceroid lipofuscinosis (vLINCL), a lysosomal storage disorder marked by progressive mental deterioration and blindness; part of a group of severe inherited neurodegenerative disorders affecting children wherein lysosomes accumulate storage material, causing the death of neurons. CLN6 is one of eight proteins, including CLN1-8, that are associated with NCL.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9541R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9541R-CY3
Lokale Artikelnummer::
BOSSBS-9541R-CY3
Beschreibung:
Orai2 is a 254 amino acid multi-pass membrane protein that belongs to the orai family of proteins. Localizing to the plasma membrane, Orai2 plays an important role in store-operated calcium (SOC) entry, a process involving Ca2+ influx and replenishment of Ca2+ stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca2+ mobilizing agents. CRAC channels are responsible for medi-ating calcium influx in T-cells and play an important role in the immune response. Orai2 specifically increases the Ca2+-selective current through coaction with the Ca2+ sensor Stim1.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.
Artikel-Nr:
(BOSSBS-11703R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11703R-CY3
Lokale Artikelnummer::
BOSSBS-11703R-CY3
Beschreibung:
FMR2 is a 1311 amino acid nuclear protein belonging to the AF4 family. Expressed in the brain, placenta and lung, FMR2 exists as two isoforms produced by alternative splicing. Defects in the gene that encodes FMR2 have been found to be a cause of FRAXE, an X-linked form of mental retardation. Individuals expressing the FRAXE site also have more than two-hundred copies of a GCC repeat adjacent to CpG island, compared to six to thirty-five copies of the GCC repeat in a normal individual. It is believed that loss of FMR2 expression causes this GCC expansion of the FRAXE site.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5751R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5751R-A750
Lokale Artikelnummer::
BOSSBS-5751R-A750
Beschreibung:
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. MATK is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12366R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12366R-A488
Lokale Artikelnummer::
BOSSBS-12366R-A488
Beschreibung:
SUMF1 is a 374 amino acid alternatively spliced protein that localizes to the lumen of the endoplasmic reticulum and belongs to the sulfatase-modifying factor family. Expressed ubiquitously with highest expression in liver, kidney and pancreas, SUMF1 exists as either a monomer, a homodimer or a heterodimer (with SUMF2) and functions to oxidize sulfatase cysteine residues to an active FGIy residue, thereby playing an important role in sulfatase activity. Defects in the gene encoding SUMF1 are the cause of multiple sulfatase deficiency (MSD), a heterogeneous disorder characterized by metachromatic leukodystrophy, mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis, neurologic deterioration and developmental delay.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13325R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13325R-HRP
Lokale Artikelnummer::
BOSSBS-13325R-HRP
Beschreibung:
GDE4 is a 314 amino acid cytoplasmic and multi-pass membrane protein that belongs to the glycerophosphoryl diester phosphodiesterase family. Expressed in small intestine, placenta, kidney, ovary, thymus, pancreas, spleen, liver and peripheral blood leukocytes, GDE4 contains one GDPD domain and exists as three alternatively spliced isoforms. GDE4 is encoded by a gene that maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.
Artikel-Nr:
(BOSSBS-9991R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9991R-A750
Lokale Artikelnummer::
BOSSBS-9991R-A750
Beschreibung:
C4orf22 is a 233 amino acid protein that exists as three alternatively spliced isoforms and are encoded by a gene encoding maping to human chromosome 4, which represents approximately 6% of the human genome and contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington's disease, is on chromosome 4. FGFR-3 is also encoded by a gene that maps to chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11315R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11315R-FITC
Lokale Artikelnummer::
BOSSBS-11315R-FITC
Beschreibung:
MPP3, also known as Discs large homolog 3 (DLG3), is a 585 amino acid protein belonging to the MAGUK family. Proteins in the MAGUK family, including CASK, ZO-1, ZO-2, p55 and MPP2, are known to regulate cell proliferation, intracellular junctions and signaling pathways by interacting with the cytoskeleton. MPP3 contains one guanylate kinase-like domain, one PDZ domain, two L27 domains and one SH3 domain. Via the PDZ domain, MMP3 interacts with the C-terminus of TSLC1. MMP3 has also been found to interact with SR-2A and SR-4.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11373R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11373R-A647
Lokale Artikelnummer::
BOSSBS-11373R-A647
Beschreibung:
The synaptogyrin family of proteins are integral membrane proteins containing four transmembrane regions. Synaptogyrins are tyrosine-phosphorylated proteins with two neuronal (Synaptogyrins 1 and 3) and one ubiquitous (Synaptogyrin-2) isoform. Synaptophysin and synaptogyrin represent the major constituents of synaptic vesicles. Synaptogyrin-1 is associated with presynaptic vesicles in neuronal cells. Synaptogyrin-2, also known as Cellugyrin has a tyrosine phosphorylated C-terminal cytoplasmic tail, and is involved in the regulation of membrane traffic in non-neuronal cells. Synaptogyrin-3 is expressed mainly in brain and placenta. The SYNGR4 gene encodes for the 234 amino acid protein Synaptogyrin-4.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11406R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11406R-A647
Lokale Artikelnummer::
BOSSBS-11406R-A647
Beschreibung:
GIOT-1 is a 563 amino acid protein belonging to the Krüppel C2H2-type zinc-finger protein family. Localized to the nucleus, GIOT-1 is widely expressed in tissues, with highest levels in liver, kidney, small intestine, pancreas and thymus. GIOT-1 contains 12 C2H2-type zinc fincers and one KRAB domain. Because the KRAB domain functions as a transcriptional repressor when attached to the template DNA, GIOT-1 is thought to be involved in transcriptional regulation. The gene encoding GIOT-1 is localized to chromosome 19q13.12 and two isoforms of GIOT-1 exist as a result of alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12353R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12353R-HRP
Lokale Artikelnummer::
BOSSBS-12353R-HRP
Beschreibung:
HES7 is a 225 amino acid transcriptional repressor protein. Localized to the nucleus, HES7 represses transcription of N box- and E box-containing promoters. HES7, along with family member HES1, is thought to cooperatively regulate somite formation in the presomitic mesoderm. HES7 may also be essential for coordinated somite segmentation by acting as a segmentation clock. HES7 contains one basic helix-loop-helix (bHLH) domain and one Orange domain. Mutations in HES7 have been found to cause spondylocostal dysostosis, an autosomal recessive disorder characterized by deformities of the chest and spine.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15105R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15105R-HRP
Lokale Artikelnummer::
BOSSBS-15105R-HRP
Beschreibung:
C20orf202 is a 122 amino acid protein that is pending further characterization. The gene encoding C20orf202 maps to human chromosome 20. Comprising approximately 2% of the human genome, chromosome 20 contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Additionally, chromosome 20 contains a region with numerous genes which are thought to be important for seminal production and may be potential targets for male contraception.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12353R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12353R-A488
Lokale Artikelnummer::
BOSSBS-12353R-A488
Beschreibung:
HES7 is a 225 amino acid transcriptional repressor protein. Localized to the nucleus, HES7 represses transcription of N box- and E box-containing promoters. HES7, along with family member HES1, is thought to cooperatively regulate somite formation in the presomitic mesoderm. HES7 may also be essential for coordinated somite segmentation by acting as a segmentation clock. HES7 contains one basic helix-loop-helix (bHLH) domain and one Orange domain. Mutations in HES7 have been found to cause spondylocostal dysostosis, an autosomal recessive disorder characterized by deformities of the chest and spine.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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