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3-Cyano-2,6-difluorobenzoic+acid
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3-Cyano-2,6-difluorobenzoic+acid
Lieferant:
COMBI-BLOCKS
Beschreibung:
2,6-Dimethoxy-3-pyridinboronsäurepinakolester
Lieferant:
COMBI-BLOCKS
Beschreibung:
2,6-Dichlor-3-nitrophenylboronsäure
Artikel-Nr:
(COBBPN-8736-1G)
Lieferant:
COMBI-BLOCKS
Hersteller-Artikelnummer::
PN-8736-1G
Lokale Artikelnummer::
COBBPN-8736-1G
Beschreibung:
2,6-Difluor-4-formylphenylboronsäurepinakolester
VE:
1 * 1 g
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(COBBPN-5680-1G)
Lieferant:
COMBI-BLOCKS
Hersteller-Artikelnummer::
PN-5680-1G
Lokale Artikelnummer::
COBBPN-5680-1G
Beschreibung:
2,6-Dimethoxy-4-pyridinboronsäurepinakolester
VE:
1 * 1 g
This is a MarketSource item. Additional charges may apply
Lieferant:
FLUOROCHEM
Beschreibung:
2,6-Bis(trifluormethyl)benzoesäure
Artikel-Nr:
(01324-1L)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
01324-1L
Lokale Artikelnummer::
HONC01324-1L
Beschreibung:
High purity solvents for speciation analysis by LC-ICP-MS. Rigorous purification procedures followed by UV spectroscopy, IC, and ICP-MS testing to assure high chemical purity and high UV transmittance. The blank values for metal traces in these solvents are in the ppb range or lower.
VE:
1 * 1 L
Lieferant:
COMBI-BLOCKS
Beschreibung:
2,6-Difluor-3-(2'-fluorbenzyloxy)phenylboronsäure
Lieferant:
Sigma-Aldrich
Beschreibung:
2,6-Bis(trifluormethyl)benzoesäure, Sigma-Aldrich®
Lieferant:
COMBI-BLOCKS
Beschreibung:
2,6-Difluor-3,5-dipyridinboronsäurepinakolester
Artikel-Nr:
(SIAL541079-5G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
541079-5G
Lokale Artikelnummer::
SIAL541079-5G
Beschreibung:
Ethyl-2,6-dihydroxybenzoat, Sigma-Aldrich®
VE:
1 * 5 g
Lieferant:
Thermo Scientific
Beschreibung:
2,6-Dihydroxy-9,10-anthrachinon
Artikel-Nr:
(SIALA89502-5G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
A89502-5G
Lokale Artikelnummer::
SIALA89502-5G
Beschreibung:
2,6-Dihydroxy-9,10-anthrachinon, Sigma-Aldrich®
VE:
1 * 5 g
Artikel-Nr:
(BOSSBS-1135R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1135R-HRP
Lokale Artikelnummer::
BOSSBS-1135R-HRP
Beschreibung:
c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1135R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1135R-A555
Lokale Artikelnummer::
BOSSBS-1135R-A555
Beschreibung:
c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1135R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1135R-A647
Lokale Artikelnummer::
BOSSBS-1135R-A647
Beschreibung:
c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1135R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1135R-CY5.5
Lokale Artikelnummer::
BOSSBS-1135R-CY5.5
Beschreibung:
c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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