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Beschreibung:   Huntington disease is associated with the expansion of a polyglutamine tract, greater than 35 repeats, in the HD gene product, huntingtin. HIP1, a membrane-associated protein, binds specifically to the N-terminus of human huntingtin. HIP1 is ubiquitously expressed in different brain regions at low levels and exhibits nearly identical subcellular fractionation as huntingtin. The HIP1 gene locates to the human chromosome 7q11.23. The huntingtin-HIP1 interaction is restricted to the brain and is inversely correlated to the polyglutamine length in the huntingtin, suggesting that loss of normal huntingtin-HIP1 interaction may compromise the membrane-cytoskeletal integrity in the brain. HIP1 contains an endocytic multidomain protein with a C-terminal Actin-binding domain, a central coiled-coil forming region and an N-terminal ENTH domain. HIP1 may be involved in vesicle trafficking; the structural integrity of HIP1 is crucial for maintenance of normal vesicle size in vivo. HIP12 is a non-proapoptotic member of the HIP gene family that is expressed in the brain and shares a similar subcellular distribution pattern with HIP1. However, HIP12 differs from HIP1 in its pattern of expression at both the mRNA and protein level. HIP12 does not directly interact with huntingtin but can interact with HIP1.
Artikel-Nr: BOSSBS-9067R-CY3
VE: 1 * 100 µl
Hersteller-Artikelnummer:: BS-9067R-CY3
Lokale Artikelnummer:: BOSSBS-9067R-CY3
Lieferant: Bioss



Menge:
 
 
 
   
Image Unavailable
Beschreibung:   Huntington disease is associated with the expansion of a polyglutamine tract, greater than 35 repeats, in the HD gene product, huntingtin. HIP1, a membrane-associated protein, binds specifically to the N-terminus of human huntingtin. HIP1 is ubiquitously expressed in different brain regions at low levels and exhibits nearly identical subcellular fractionation as huntingtin. The HIP1 gene locates to the human chromosome 7q11.23. The huntingtin-HIP1 interaction is restricted to the brain and is inversely correlated to the polyglutamine length in the huntingtin, suggesting that loss of normal huntingtin-HIP1 interaction may compromise the membrane-cytoskeletal integrity in the brain. HIP1 contains an endocytic multidomain protein with a C-terminal Actin-binding domain, a central coiled-coil forming region and an N-terminal ENTH domain. HIP1 may be involved in vesicle trafficking; the structural integrity of HIP1 is crucial for maintenance of normal vesicle size in vivo. HIP12 is a non-proapoptotic member of the HIP gene family that is expressed in the brain and shares a similar subcellular distribution pattern with HIP1. However, HIP12 differs from HIP1 in its pattern of expression at both the mRNA and protein level. HIP12 does not directly interact with huntingtin but can interact with HIP1.
Artikel-Nr: BOSSBS-9067R-A555
VE: 1 * 100 µl
Hersteller-Artikelnummer:: BS-9067R-A555
Lokale Artikelnummer:: BOSSBS-9067R-A555
Lieferant: Bioss



Menge:
 
 
 
   
Image Unavailable
Beschreibung:   Huntington disease is associated with the expansion of a polyglutamine tract, greater than 35 repeats, in the HD gene product, huntingtin. HIP1, a membrane-associated protein, binds specifically to the N-terminus of human huntingtin. HIP1 is ubiquitously expressed in different brain regions at low levels and exhibits nearly identical subcellular fractionation as huntingtin. The HIP1 gene locates to the human chromosome 7q11.23. The huntingtin-HIP1 interaction is restricted to the brain and is inversely correlated to the polyglutamine length in the huntingtin, suggesting that loss of normal huntingtin-HIP1 interaction may compromise the membrane-cytoskeletal integrity in the brain. HIP1 contains an endocytic multidomain protein with a C-terminal Actin-binding domain, a central coiled-coil forming region and an N-terminal ENTH domain. HIP1 may be involved in vesicle trafficking; the structural integrity of HIP1 is crucial for maintenance of normal vesicle sise <i>in vivo</i>. HIP12 is a non-proapoptotic member of the HIP gene family that is expressed in the brain and shares a similar subcellular distribution pattern with HIP1. However, HIP12 differs from HIP1 in its pattern of expression at both the mRNA and protein level. HIP12 does not directly interact with huntingtin but can interact with HIP1.
Artikel-Nr: BOSSBS-9067R-A750
VE: 1 * 100 µl
Hersteller-Artikelnummer:: BS-9067R-A750
Lokale Artikelnummer:: BOSSBS-9067R-A750
Lieferant: Bioss



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Beschreibung:   Bromkresolgrün Reag. Ph. Eur., Fluka™
Artikel-Nr: 32742-25G
VE: 1 * 25 g
Hersteller-Artikelnummer:: 32742-25G
Lokale Artikelnummer:: HONC32742-25G
Lieferant: Honeywell Chemicals



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Beschreibung:   Edelstahl 18/10, antimagnetisch. Universal-Spatel für eine Vielzahl von Anwendungen.
Artikel-Nr: 231-0541
VE: 1 * 1 ST
Hersteller-Artikelnummer:: 3020
Lokale Artikelnummer:: BOCH3020
Lieferant: BOCHEM



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Beschreibung:   4-Chlor-2-(trifluormethyl)chinazolin
Artikel-Nr: MAYBCD02952.250
VE: 1 * 250 mg
Hersteller-Artikelnummer:: CD02952.250
Lokale Artikelnummer:: MAYBCD02952.250
Lieferant: Thermo Scientific



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Beschreibung:   Lithiumbromid, wasserfrei ≥99%
Artikel-Nr: 13408.22
VE: 1 * 100 g
Hersteller-Artikelnummer:: 13408.22
Lokale Artikelnummer:: ALFA13408.22
Lieferant: Alfa Aesar



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MSDS Sicherheitsdatenblätter Certificate Analysenzertifikate    
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Beschreibung:   2-Bromterephthalsäure, Sigma-Aldrich®
Artikel-Nr: SIAL115274-25G
VE: 1 * 25 g
Hersteller-Artikelnummer:: 115274-25G
Lokale Artikelnummer:: SIAL115274-25G
Lieferant: Sigma-Aldrich



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Beschreibung:   HDPE, durchscheinend.
Artikel-Nr: 215-0916
VE: 1 * 1 ST
Hersteller-Artikelnummer:: 609
Lokale Artikelnummer:: LAMA609
Lieferant: LAMAPLAST



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Beschreibung:   2,2-Dimethylpentan, Sigma-Aldrich®
Artikel-Nr: SIAL110671-10G
VE: 1 * 10 g
Hersteller-Artikelnummer:: 110671-10G
Lokale Artikelnummer:: SIAL110671-10G
Lieferant: Sigma-Aldrich



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Beschreibung:   PTFE, starkwandig.
Artikel-Nr: 215-1744
VE: 1 * 1 ST
Hersteller-Artikelnummer:: 130538
Lokale Artikelnummer:: BRND130538
Lieferant: Brand



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Beschreibung:   DYMO-kompatible Direkt-Thermo-Kryo-Etiketten mit permanenter Klebeseite.
Artikel-Nr: GAINEF1F-020BL
VE: 1 * 1 Rolle
Hersteller-Artikelnummer:: EF1F-020BL
Lokale Artikelnummer:: GAINEF1F-020BL
Lieferant: GA



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Beschreibung:   Rod baffles featuring a stainless steel core fully encapsulated in PTFE.
Artikel-Nr: COWIPC708.016.250
VE: 1 * 1 ST
Hersteller-Artikelnummer:: PC708.016.250
Lokale Artikelnummer:: COWIPC708.016.250
Lieferant: COWIE



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Beschreibung:   DURAN®, borosilicate glass 3.3, clear.
Artikel-Nr: SCOT286154602
VE: 1 * 50 ST
Hersteller-Artikelnummer:: 286154602
Lokale Artikelnummer:: SCOT286154602
Lieferant: DWK Life Sciences



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Beschreibung:   9,10-Dihydrophenanthren, Sigma-Aldrich®
Artikel-Nr: SIALD106003-5G
VE: 1 * 5 g
Hersteller-Artikelnummer:: D106003-5G
Lokale Artikelnummer:: SIALD106003-5G
Lieferant: Sigma-Aldrich



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Beschreibung:   Halbschuhe aus Glattleder mit Air-Light®-Futter und Zwei-Schichten-PU-Sohle.
Artikel-Nr: 114-2381
VE: 1 * 1 PAAR
Hersteller-Artikelnummer:: 0082183/35
Lokale Artikelnummer:: JALC0082183/35
Lieferant: Jallatte



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