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4-Hydroxy-2,3,5-trifluorobenzoic+acid
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4-Hydroxy-2,3,5-trifluorobenzoic+acid
Artikel-Nr:
(BOSSBS-4006R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4006R-CY7
Lokale Artikelnummer::
BOSSBS-4006R-CY7
Beschreibung:
Hydrolyzes cerebroside sulfate.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1487R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1487R-A680
Lokale Artikelnummer::
BOSSBS-1487R-A680
Beschreibung:
This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2440R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2440R-A350
Lokale Artikelnummer::
BOSSBS-2440R-A350
Beschreibung:
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0169R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0169R-A488
Lokale Artikelnummer::
BOSSBS-0169R-A488
Beschreibung:
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9462R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9462R-A488
Lokale Artikelnummer::
BOSSBS-9462R-A488
Beschreibung:
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9262R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9262R-A680
Lokale Artikelnummer::
BOSSBS-9262R-A680
Beschreibung:
The RING finger motif is a specialised DNA-binding zinc finger domain found in many transcriptional regulatory proteins. The ring finger protein (RNF) family includes any protein containing the signature RING finger motif. RNF186 (RING finger protein 186) is a 227 amino acid multi-pass membrane protein containing one RING-type zinc finger. The gene encoding RNF186 maps to human chromosome 1p36.13. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4874R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4874R
Lokale Artikelnummer::
BOSSBS-4874R
Beschreibung:
The complement factor C3 consists of an alpha and a beta chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical mannose binding lectin activation pathway leads to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a and C3b. Further degradation leads to the formation of the alpha chain products C3d, C3g and C3c. C3 is an acute phase protein that is produced by a wide range of tissues, including renal epithelial cells and hepatocytes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15497R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15497R-CY7
Lokale Artikelnummer::
BOSSBS-15497R-CY7
Beschreibung:
DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6567R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6567R-A750
Lokale Artikelnummer::
BOSSBS-6567R-A750
Beschreibung:
Papillomavirus Regulatory Factor 1/HDBP2 is a novel transcription factor shuttling between nucleus and cytoplasm and binds to the specific GCCGGCG, which is an essential cis-element for Huntington's disease gene expression.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3221R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3221R-A350
Lokale Artikelnummer::
BOSSBS-3221R-A350
Beschreibung:
HP1 gamma appears to be involved in transcriptional silencing in heterochromatin-like complexes. It recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. HP1 gamma may contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR) and involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11246R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11246R-A680
Lokale Artikelnummer::
BOSSBS-11246R-A680
Beschreibung:
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12332R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12332R-A750
Lokale Artikelnummer::
BOSSBS-12332R-A750
Beschreibung:
Dyrk is the homolog of the Drosophila mnb (minibrain) gene, which is required for neurogenesis. Dyrk is a dual-specificity tyrosine kinase and serine/threonine kinase, which is itself regulated by tyrosine phosphorylation. Several mammalian Dyrk related proteins have been identified and are thought to compose a family of dual specificity protein kinases. Dyrk family members, including Dyrk1A (originally Dyrk), Dyrk1B, Dryk1C, Dyrk2, Dyrk3, Dyrk4A and Dyrk4B, are thought to be involved in diverse cellular functions. Dyrk1A is a candidate gene that may be involved in Downs syndrome, and it has been found to be somewhat overexpressed in Downs syndrome. Two isoforms of human fetal brain Dyrk2 exist: a deduced 528-amino acid protein and a protein containing 73 additional amino acids at the amino terminus. Dyrk3 is strongly expressed in testis, only after the onset of spermatogenesis, and very weakly expressed in spleen and adrenal gland. The genes which encode Dyrk2 and Dyrk3 map to human chromosomes 12 and 1q32, respectively.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12463R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12463R-A750
Lokale Artikelnummer::
BOSSBS-12463R-A750
Beschreibung:
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6071R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6071R-HRP
Lokale Artikelnummer::
BOSSBS-6071R-HRP
Beschreibung:
Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9235R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9235R-CY5.5
Lokale Artikelnummer::
BOSSBS-9235R-CY5.5
Beschreibung:
The members of the murine Cdx family (Cdx1, Cdx2, and Cdx4) are members of the caudal-type homeobox family of genes, which are homologues of the Drosophila ‘caudal’ gene required for anterior-posterior regional identity. The intestine-specific transcription factors Cdx1 and Cdx2 are candidate genes for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. The relative expression of Cdx1 to Cdx2 protein may be important in the anterior to posterior patterning of the intestinal epithelium and in defining patterns of proliferation and differentiation along the crypt-villus axis. Expression of the Cdx1 homeobox gene in epithelial intestinal cells promotes cellular growth and differentiation. Cdx1 positively regulates its own expression. Cdx1 and Cdx2 are expressed in the small intestine and colon of fetus and adult. A decrease in human Cdx1 and/or Cdx2 expression is associated with colorectal tumorigenesis. Both Cdx1 and Cdx2 genes must be expressed to reduce tumorigenic potential, to increase sensitivity to apoptosis and to reduce cell migration, suggesting that the two genes control the normal phenotype by independent pathways. The human Cdx1 gene maps to chromosome 5q31-q33 and encodes a 265-amino acid protein.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9570R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9570R
Lokale Artikelnummer::
BOSSBS-9570R
Beschreibung:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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