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3-Hydroxyanthranilsäure
Artikel-Nr:
(BOSSBS-5394R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5394R-A555
Lokale Artikelnummer::
BOSSBS-5394R-A555
Beschreibung:
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11497R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11497R-A647
Lokale Artikelnummer::
BOSSBS-11497R-A647
Beschreibung:
VAX2 is a 290 amino acid homeobox protein that plays a crucial role in development of the eye, particularly in the specification of the ventral optic vesicle and in establishment of a correct dorsoventral pattern. VAX2 acts as a transcription factor with VAX1 to cooperatively regulate retinal differentiation, neuroepithelial cell proliferation and axial polarization in the retina. Together, VAX1 and VAX2 repress transcription of Pax-6, a strong inducer of retinal development. VAX1 and VAX2 localize to the nucleus and contain one homeobox DNA-binding domain each.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2428R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2428R-A555
Lokale Artikelnummer::
BOSSBS-2428R-A555
Beschreibung:
The protein encoded by this gene is a cytokine that actsas a regulator of a variety of hematopoietic cells. This cytokinestimulates cell proliferation and prevents apoptosis. It functionsthrough the interleukin 9 receptor (IL9R), which activatesdifferent signal transducer and activator (STAT) proteins and thusconnects this cytokine to various biological processes. The geneencoding this cytokine has been identified as a candidate gene forasthma. Genetic studies on a mouse model of asthma demonstratedthat this cytokine is a determining factor in the pathogenesis ofbronchial hyperresponsiveness. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10355R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10355R-A647
Lokale Artikelnummer::
BOSSBS-10355R-A647
Beschreibung:
The c Abl proto oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) As the result of the fusion of c Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7688R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7688R-A555
Lokale Artikelnummer::
BOSSBS-7688R-A555
Beschreibung:
This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5353R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5353R-A488
Lokale Artikelnummer::
BOSSBS-5353R-A488
Beschreibung:
FANCG, involved in Fanconi anemia, confers resistance to both hygromycin and mitomycin C. FANCG contains a 5-prime GC-rich untranslated region characteristic of housekeeping genes. The putative 622-amino acid protein has a leucine-zipper motif at its N-terminus. Fanconi anemia is an autosomal recessive disorder with diverse clinical symptoms, including developmental anomalies, bone marrow failure, and early occurrence of malignancies. A minimum of 8 FA genes have been identified.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8878R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8878R-A647
Lokale Artikelnummer::
BOSSBS-8878R-A647
Beschreibung:
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10354R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10354R-A555
Lokale Artikelnummer::
BOSSBS-10354R-A555
Beschreibung:
The c Abl proto oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) As the result of the fusion of c Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11901R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11901R-A488
Lokale Artikelnummer::
BOSSBS-11901R-A488
Beschreibung:
The helix-loop-helix (HLH) structures are known motifs commonly found in membrane-active and DNA-binding proteins. The helix-loop-helix proteins HEN1 and HEN2 are DNA-binding proteins that may be involved in cell-type determination in the early nervous system. Studies of expression in normal tissues have demonstrated expression of NHLH1/NSCL-1 and NHLH2/NSCL-2, the genes encoding HEN1 and HEN2, in the developing central and peripheral nervous system, specifically in developing neurons.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0760R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0760R-A647
Lokale Artikelnummer::
BOSSBS-0760R-A647
Beschreibung:
Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis. Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. Isoform 1 is recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6369R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6369R-A488
Lokale Artikelnummer::
BOSSBS-6369R-A488
Beschreibung:
This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1693R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1693R-A350
Lokale Artikelnummer::
BOSSBS-1693R-A350
Beschreibung:
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5204R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5204R-A350
Lokale Artikelnummer::
BOSSBS-5204R-A350
Beschreibung:
E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3003R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3003R-A488
Lokale Artikelnummer::
BOSSBS-3003R-A488
Beschreibung:
APS (adapter protein with Pleckstrin homology and Src homology 2 domains) is a member of the Lnk family, an adaptor protein that is involved in B cell signaling, insulin signaling and cytoskeletal reorganisation. A PH and an SH2 domain containing adaptor protein that links activated tyrosine kinases to signaling pathways. It is tyrosine phosphorylated by JAK2, KIT and other kinases during B cell receptor stimulation of many different cytokines, chemokines and leukokines. APS has been shown to inhibit the JAK STAT pathway in collaboration with cCbl.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0988R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0988R-A488
Lokale Artikelnummer::
BOSSBS-0988R-A488
Beschreibung:
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2378R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2378R-A555
Lokale Artikelnummer::
BOSSBS-2378R-A555
Beschreibung:
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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