4,6-Dimethoxypyrimidin-5-amine
Artikel-Nr:
(BOSSBS-1302R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1302R-A680
Lokale Artikelnummer::
BOSSBS-1302R-A680
Beschreibung:
Glutamic Acid Decarboxylase (GAD) catalyses the conversion of L glutamate to g-aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the brain, and a putative paracrine signal molecule in pancreatic islets. GAD has a restricted tissue distribution. It is highly expressed in the cytoplasm of GABAergic neurons in the central nervous system (CNS) and pancreatic beta cells. It is also present in other non-neuronal tissues such as testis, oviduct and ovary. GAD is also transiently expressed in non-GABAergic cells of the embryonic and adult nervous system, suggesting its involvement in development and plasticity. GAD exists as two isoforms, GAD65 and GAD67 (molecular masses of 65 and 67 kD, respectively) that are encoded by two different genes. GAD65 is an ampiphilic, membraneanchored protein, (585 amino acid residues) and is encoded on human chromosome 10. GAD67 is a cytoplasmic protein (594 amino acid residues) and is encoded on chromosome 2. There is 64% amino acid identity between the two isoforms, with the highest diversity located at the N terminus, which in GAD65 is required for targeting the enzyme to GABA-containing secretory vesicles. The two isoforms appear to have distinct intraneuronal distribution in the brain. GAD65 has been identified as an autoantigen in insulindependent diabetes mellitus (IDDM) and stiff-man syndrome (SMS), IDDM is an autoimmune disease that results from T cell mediated destruction of pancreatic insulin-secreting beta cells. Islet-reactive T cells and primarily to GAD65 (also named beta cell autoantigen) can be detected in peripheral blood of 80% of recent-onset IDD patients and in pre-diabetic high-risk subjects before onset of clinical symptoms. This suggests that GAD may be an important marker in the early stages of the disease.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1302R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1302R-A555
Lokale Artikelnummer::
BOSSBS-1302R-A555
Beschreibung:
Glutamic Acid Decarboxylase (GAD) catalyzes the conversion of L glutamate to g-aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the brain, and a putative paracrine signal molecule in pancreatic islets. GAD has a restricted tissue distribution. It is highly expressed in the cytoplasm of GABAergic neurons in the central nervous system (CNS) and pancreatic beta cells. It is also present in other non-neuronal tissues such as testis, oviduct and ovary. GAD is also transiently expressed in non-GABAergic cells of the embryonic and adult nervous system, suggesting its involvement in development and plasticity. GAD exists as two isoforms, GAD65 and GAD67 (molecular masses of 65 and 67 kD, respectively) that are encoded by two different genes. GAD65 is an ampiphilic, membraneanchored protein, (585 amino acid residues) and is encoded on human chromosome 10. GAD67 is a cytoplasmic protein (594 amino acid residues) and is encoded on chromosome 2. There is 64% amino acid identity between the two isoforms, with the highest diversity located at the N terminus, which in GAD65 is required for targeting the enzyme to GABA-containing secretory vesicles. The two isoforms appear to have distinct intraneuronal distribution in the brain. GAD65 has been identified as an autoantigen in insulindependent diabetes mellitus (IDDM) and stiff-man syndrome (SMS), IDDM is an autoimmune disease that results from T cell mediated destruction of pancreatic insulin-secreting beta cells. Islet-reactive T cells and primarily to GAD65 (also named beta cell autoantigen) can be detected in peripheral blood of 80% of recent-onset IDD patients and in pre-diabetic high-risk subjects before onset of clinical symptoms. This suggests that GAD may be an important marker in the early stages of the disease.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI76-616)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-616
Lokale Artikelnummer::
PRSI76-616
Beschreibung:
The UCHT2 monoclonal antibody specifically reacts with human CD5, a 67 kDa type 1 transmembrane glycoprotein. CD5 is expressed on mature T cells, a subset of B cells, and peripheral blood dendritic cells. B cells that are CD5+ produce mostly IgM polyreactive antibodies. Its ligand is CD72, which is involved in T, B cell proliferation and interaction. The UCT2 antibody also recognizes non-human primate CD5.
VE:
1 * 25 Tests
New Product
Lieferant:
Lenz Laborglas GmbH & CO.KG
Beschreibung:
DURAN®, Borosilikatglas, mit parallelem Seitenhals.
Artikel-Nr:
(ACRO243262500)
Lieferant:
Thermo Scientific
Hersteller-Artikelnummer::
243262500
Lokale Artikelnummer::
ACRO243262500
Beschreibung:
Natrium 30% (w/w) Dispersion in Toluol, Ø <0.1 mm
VE:
1 * 250 mL
Artikel-Nr:
(COBBOS-7525-1G)
Lieferant:
COMBI-BLOCKS
Hersteller-Artikelnummer::
OS-7525-1G
Lokale Artikelnummer::
COBBOS-7525-1G
Beschreibung:
Chlor(1,5-cyclooctadien)iridium(I) dimer
VE:
1 * 1 g
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Lieferant:
Alfa Aesar
Beschreibung:
exo-3,6-Epoxy-1,2,3,6-tetrahydrophthalsäureanhydrid ≥98%
Lieferant:
Avantor
Beschreibung:
Salzsäure 37,0 - 38,0%, CMOS CMOS für Mikroelektronik, J.T.Baker®
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
D(+)-Galactose
Artikel-Nr:
(APOSPC446145-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC446145-1G
Lokale Artikelnummer::
APOSPC446145-1G
Beschreibung:
(E)-3-(2-Fluoro-4-hydroxyphenyl)acrylic acid 95+%
VE:
1 * 1 g
Lieferant:
VWR Chemicals
Beschreibung:
Salzsäure 5 mol/l (5 N), AVS TITRINORM volumetrische Lösung
Artikel-Nr:
(414719-4L)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
414719-4L
Lokale Artikelnummer::
HONC414719-4L
Beschreibung:
Methanol ≥99,9%, CHROMASOLV™ für Kapillar-GC-Analysen, Riedel-de Haën™
VE:
1 * 4 L
Lieferant:
MACRON AVANTOR BRAND
Beschreibung:
Salzsäure 35 - 38%, AR®, Macron Fine Chemicals™
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
6-Chlornicotinsäure 98%
Artikel-Nr:
(85848.290)
Lieferant:
VWR Chemicals
Lokale Artikelnummer::
VWRC85848.290
Beschreibung:
Salzsäure 2 mol/l (2 N) Reag. Ph. Eur. 1043503
VE:
1 * 1 L
Artikel-Nr:
(APOSOR510094-250MG)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR510094-250MG
Lokale Artikelnummer::
APOSOR510094-250MG
Beschreibung:
5-Chloro-N-methyl-3-nitropyridin-2-amine ≥97%
VE:
1 * 250 mg
Preis auf Anfrage
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