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4-Aminocyclohexancarbonsäure+(Gemisch+der+cis-+und+trans-Isomeren
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Artikel-Nr:
(BOSSBS-11785R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11785R-A555
Lokale Artikelnummer::
BOSSBS-11785R-A555
Beschreibung:
Maspardin is a 308 amino acid cytoplasmic protein that is widely expressed. Belonging to the AB hydrolase superfamily, Maspardin colocalizes with CD4 on endosomal/trans-Golgi network. It is thought that Maspardin may act as a negative regulatory factor in CD4-dependent T-cell activation. Defects in the gene encoding Maspardin are the result of hereditary spastic paraplegia autosomal recessive type 21 (also designated Mast syndrome), an autosomal recessive neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. The gene encoding Maspardin is encoded by human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11785R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11785R-A680
Lokale Artikelnummer::
BOSSBS-11785R-A680
Beschreibung:
Maspardin is a 308 amino acid cytoplasmic protein that is widely expressed. Belonging to the AB hydrolase superfamily, Maspardin colocalizes with CD4 on endosomal/trans-Golgi network. It is thought that Maspardin may act as a negative regulatory factor in CD4-dependent T-cell activation. Defects in the gene encoding Maspardin are the result of hereditary spastic paraplegia autosomal recessive type 21 (also designated Mast syndrome), an autosomal recessive neurodegenerative disorder characterised by a slow, gradual, progressive weakness and spasticity of the lower limbs. The gene encoding Maspardin is encoded by human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome.
VE:
1 * 100 µl
Lieferant:
VWR Chemicals
Beschreibung:
Sowohl Anolyt- als auch Katholyt-Lösungen weisen eine verbesserte Formulierung auf, die die Geschwindigkeit und die Genauigkeit der Titration bei der Bestimmung des Wassergehalts im Mikrogrammbereich erhöht.
Artikel-Nr:
(BOSSBS-2969R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2969R-FITC
Lokale Artikelnummer::
BOSSBS-2969R-FITC
Beschreibung:
E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2441R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2441R-CY3
Lokale Artikelnummer::
BOSSBS-2441R-CY3
Beschreibung:
Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2441R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2441R-A488
Lokale Artikelnummer::
BOSSBS-2441R-A488
Beschreibung:
Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1970R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1970R-A488
Lokale Artikelnummer::
BOSSBS-1970R-A488
Beschreibung:
Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1970R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1970R-A647
Lokale Artikelnummer::
BOSSBS-1970R-A647
Beschreibung:
Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2969R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2969R-A555
Lokale Artikelnummer::
BOSSBS-2969R-A555
Beschreibung:
E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13454R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13454R-CY3
Lokale Artikelnummer::
BOSSBS-13454R-CY3
Beschreibung:
GMEB-1 is a 573 amino acid protein that contains one SAND domain and is a member of the KDWK family of combinatorial transcription modulators. Localized to both the cytoplasm and the nucleus, GMEB-1 forms a heterodimer with GMEB-2 (Glucocorticoid modulatory element-binding protein 2) and, once associated with GMEB-2, plays a key role in parvovirus DNA replication. In addition, GMEB-1 functions alone as a trans-acting factor that, by binding to glucocorticoid modulatory elements (GMEs) in TAT (tyrosine aminotransferase) promoters, increases intracellular sensitivity to glucocorticoid concentrations. GMEB-1 also interacts with initiator procaspases and, via this interaction, can inhibit caspase-induced apoptosis. Due to alternative splicing events, GMEB-1 is expressed as two isoforms.
VE:
1 * 100 µl
Artikel-Nr:
(SIAL317675-1KG)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
317675-1KG
Lokale Artikelnummer::
SIAL317675-1KG
Beschreibung:
Ethyloleat, Sigma-Aldrich®
VE:
1 * 1 kg
Lieferant:
Thermo Scientific
Beschreibung:
Colecalciferol (Vitamin D3) 99%, kristallin
Lieferant:
COMBI-BLOCKS
Beschreibung:
trans-3-(Tetrahydropyran-2-yloxy)propen-1-ylboronsäurepinakolester
Lieferant:
Hichrom Limited
Beschreibung:
Diese Avantor® Hichrom C18-Säulen bieten eine hohe Leistung, um die anspruchsvollsten Umkehrphasenanwendungen zu bewältigen. Die Verwendung hochreiner Silica, fortschrittlicher Bindungstechnologie, überlegener Säulenspezifikation und umfassender Chargenvalidierung tragen alle zur hervorragenden Reproduzierbarkeit der Säulen bei.
Artikel-Nr:
(BOSSBS-13454R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13454R-A350
Lokale Artikelnummer::
BOSSBS-13454R-A350
Beschreibung:
GMEB-1 is a 573 amino acid protein that contains one SAND domain and is a member of the KDWK family of combinatorial transcription modulators. Localized to both the cytoplasm and the nucleus, GMEB-1 forms a heterodimer with GMEB-2 (Glucocorticoid modulatory element-binding protein 2) and, once associated with GMEB-2, plays a key role in parvovirus DNA replication. In addition, GMEB-1 functions alone as a trans-acting factor that, by binding to glucocorticoid modulatory elements (GMEs) in TAT (tyrosine aminotransferase) promoters, increases intracellular sensitivity to glucocorticoid concentrations. GMEB-1 also interacts with initiator procaspases and, via this interaction, can inhibit caspase-induced apoptosis. Due to alternative splicing events, GMEB-1 is expressed as two isoforms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13454R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13454R-FITC
Lokale Artikelnummer::
BOSSBS-13454R-FITC
Beschreibung:
GMEB-1 is a 573 amino acid protein that contains one SAND domain and is a member of the KDWK family of combinatorial transcription modulators. Localized to both the cytoplasm and the nucleus, GMEB-1 forms a heterodimer with GMEB-2 (Glucocorticoid modulatory element-binding protein 2) and, once associated with GMEB-2, plays a key role in parvovirus DNA replication. In addition, GMEB-1 functions alone as a trans-acting factor that, by binding to glucocorticoid modulatory elements (GMEs) in TAT (tyrosine aminotransferase) promoters, increases intracellular sensitivity to glucocorticoid concentrations. GMEB-1 also interacts with initiator procaspases and, via this interaction, can inhibit caspase-induced apoptosis. Due to alternative splicing events, GMEB-1 is expressed as two isoforms.
VE:
1 * 100 µl
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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