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4-Aminocyclohexancarbonsäure+(Gemisch+der+cis-+und+trans-Isomeren
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Lieferant:
BARNSTEAD THERMOLYNE
Beschreibung:
Diese Magnetrührer mit Heizplatte bieten eine präzise steuerbare Rührleistung, ausgezeichnete Sicherheit und eine überlegene Temperaturleistung für Ihre Routineaufgaben. Sie sind in drei Größen erhältlich und bieten Flexibilität von Chemikalien im Mikromaßstab zu Produktionsabläufen. Die Geräte verfügen über innovative Technologie für das Rühren bei niedrigen Drehzahlen und eine stärkere magnetische Kopplung. Die Heizplatten sind in Keramik oder Aluminium erhältlich und das Design hält auslaufende Flüssigkeiten von der Geräteelektronik fern.
Artikel-Nr:
(BOSSBS-13664R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13664R-A350
Lokale Artikelnummer::
BOSSBS-13664R-A350
Beschreibung:
The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. During Th1 differentiation a reduction in the association of Jak1 with the IL4 Receptor correlated with the appearance of SOCS5. SOCS5 protein was preferentially expressed in committed Th1 cells and interacted with the cytoplasmic region of the IL4 Receptor alpha chain irrespective of receptor tyrosine phosphorylation. This unconventional interaction of SOCS5 protein with IL4 Receptor resulted in the inhibition of IL4-mediated signal transducer and activator of transcription-6 activation. T cells from transgenic mice constitutively expressing SOCS5 exhibited a significant reduction of IL4-mediated Th2 development. Therefore, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11884R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11884R-CY3
Lokale Artikelnummer::
BOSSBS-11884R-CY3
Beschreibung:
The Drosophila atonal gene produces a protein with basic helix loop helix (bHLH) domains that plays an essential role in the development of the Drosophila nervous system. Mammalian atonal homolog 2 (MATH-2) is a helix-loop-helix (HLH) transcription factor that is structurally homologous to the product of Drosophila atonal gene. MATH-2 is a 337 amino acid protein with an atonal-related basic HLH domain. In mice, expression of MATH-2 takes place by embryonic day 11.5 and initially localizes to the wall of brain vesicles and in the spinal cord. It is expressed in the cortical plate and the mantle layer in the developing central nervous system, and is limited to the nervous system in adults. Adult mouse cerebrums produce a high level of MATH-2 RNA with lower levels in other neuronal tissues. Research studies suggest that MATH-2 may function as a trans-acting factor involved in the development and maintenance of the mammalian nervous system.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11333R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11333R-CY7
Lokale Artikelnummer::
BOSSBS-11333R-CY7
Beschreibung:
Clathrin-coated pits and vesicles are assembled for receptor-mediated endocytosis through interaction with Clathrin associated protein complexes. Vesicle transport is mediated from the trans-Golgi network by the adapter complex AP-1 and from the plasma membrane by the AP-2 complex. The AP-1 and AP-2 adapter protein complexes consist of Clathrin binding Adaptin proteins (g and b1 for AP-1, a and b2 for AP-2) and two smaller subunits known as AP50 and AP17. The a and b Adaptin chains have a similar two-domain organization with C-terminal domains that vary in both sequence and length. a-Adaptin splice variants A and C display variable relative expression levels and differential distribution in different tissues. AP-3 (also designated AP180 or F1-20) is a synapse-specific Clathrin assembly protein. The protein CALM (Clathrin assembly protein lymphoid myeloid leukemia) is highly homologous to AP180 and may also be involved in Clathrin assembly.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2835R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2835R-A350
Lokale Artikelnummer::
BOSSBS-2835R-A350
Beschreibung:
The ankyrin repeat and SOCS box containing (ASB) protein family is comprised of members which each contain "SOCS boxes" but differ from other families of protein in the motifs they contain upstream of the SOCS box. SOCS boxes are carboxy terminal regions of homology found in the suppressor of cytokine signaling family of proteins. The box region is thought to be the point of interaction between SOCS proteins and E3 ubiquitin ligases. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. The gene is induced by all trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11241R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11241R-A680
Lokale Artikelnummer::
BOSSBS-11241R-A680
Beschreibung:
Adaptins are heterotetrameric subunits of adaptors, which are complexes involved in the formation of Clathrin-coated pits for vesicle-mediated endocytosis. Clathrin and its associated heterotetrameric protein complexes make up the main protein components of the coat surrounding the cytoplasmic face of coated vesicles. The Adaptin family, comprising a, b, and g classes, is also responsible for the transport of ligand-receptor complexes from plasma membranes and the trans-Golgi network to lysosomes. Two main types of adaptor proteins (APs), AP-1 and AP-2, are found in Clathrin-coated structures located at the Golgi complex and the plasma membrane of mammalian cells, respectively. Adaptor protein complex 2 (AP-2) is composed of two large Adaptins (a1A/AP2A1 and b1/AP2B1), a medium Adaptin (m2/AP-2m1) and a small Adaptin (s2 long/AP2S1). AP-2m1, a 435 amino acid protein, links Clathrin to receptors in coated vesicles.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11242R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11242R-A750
Lokale Artikelnummer::
BOSSBS-11242R-A750
Beschreibung:
Adaptins are heterotetrameric subunits of adaptors, which are complexes involved in the formation of Clathrin-coated pits for vesicle-mediated endocytosis. Clathrin and its associated heterotetrameric protein complexes make up the main protein components of the coat surrounding the cytoplasmic face of coated vesicles. The Adaptin family, comprising a, b, and g classes, is also responsible for the transport of ligand-receptor complexes from plasma membranes and the trans-Golgi network to lysosomes. Two main types of adaptor proteins (APs), AP-1 and AP-2, are found in Clathrin-coated structures located at the Golgi complex and the plasma membrane of mammalian cells, respectively. Adaptor protein complex 2 (AP-2) is composed of two large Adaptins (a1A/AP2A1 and b1/AP2B1), a medium Adaptin (m2/AP-2m1) and a small Adaptin (s2 long/AP2S1). AP-2m1, a 435 amino acid protein, links Clathrin to receptors in coated vesicles.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9156R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9156R-CY5
Lokale Artikelnummer::
BOSSBS-9156R-CY5
Beschreibung:
SH3MD2 acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9). SH3MD2 may be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane. This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. There are two named isoforms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5814R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5814R-FITC
Lokale Artikelnummer::
BOSSBS-5814R-FITC
Beschreibung:
Prominin 2 is a 112 kDa glycoporotein structurally related to Prominin 1 (CD133) although amino acid similarity is not more than 30%, but their genomic organization is strikingly similar. Like Prominin 1, the prominin 2 exhibit similar membrane topology with 5 trans-membrane domains and two large glycosylated extracellular domains. Similar to Prominin1 localization, the Prominin 2 is also associated with membrane protrusions of the epithelial cells from adult kidney, and all along the digestive track and other epithelial tissues.Prominin 2 expression is down-regulated in aggressive prostate cancer cell lines and transient transfection of PROML2 expression vectors has been shown to induce apoptosis in cultured prostate cancer cells, suggesting a tumor suppressive role for Prominin 2. Prominin 2 expression is likely to be involved in growth suppression in the prostate, and down-regulation of Prominin 2 may disrupt normal prostatic homeostasis and lead to uncontrolled prostatic growth.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13664R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13664R-HRP
Lokale Artikelnummer::
BOSSBS-13664R-HRP
Beschreibung:
The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. During Th1 differentiation a reduction in the association of Jak1 with the IL4 Receptor correlated with the appearance of SOCS5. SOCS5 protein was preferentially expressed in committed Th1 cells and interacted with the cytoplasmic region of the IL4 Receptor alpha chain irrespective of receptor tyrosine phosphorylation. This unconventional interaction of SOCS5 protein with IL4 Receptor resulted in the inhibition of IL4-mediated signal transducer and activator of transcription-6 activation. T cells from transgenic mice constitutively expressing SOCS5 exhibited a significant reduction of IL4-mediated Th2 development. Therefore, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance.
VE:
1 * 100 µl
Lieferant:
HERAEUS
Beschreibung:
Dieser voreingestellte, leistungsstarke Plasmagefrierschrank mit –30 °C und automatischer Abtaufunktion erfüllt die strengen Anforderungen des AABB bzgl. der Lagerung von Plasma. Die V-Drive-Technologie dieser Serie bietet eine gleichmäßige Temperatur, die sich kontinuierlich an Benutzermuster anpasst und erhebliche Energieeinsparungen ermöglicht, ohne den Schutz zu beeinträchtigen.
Lieferant:
Thermo Scientific
Beschreibung:
PS, unsteril, ohne Deckel. Mit verschiedenen Oberflächenbehandlungen erhältlich: aminierte Oberfläche für eine schnelle Kupplung von Peptiden und Proteinen; Streptavidin-beschichtete Oberfläche für die schnelle Kupplung von biotinylierten Biomolekülen wie Peptiden, Antikörpern, Oligonukleotiden oder Haptenen. Außerdem verfügbar in transparenter Ausführung für kolorimetrische Assays und zur Probenaufbewahrung, in weiß für Lumineszenz- und Fluoreszenz-Assays sowie in schwarz für Fluoreszenz-Assays.
Lieferant:
MP Biomedicals
Beschreibung:
Hematoxylin is Gill’s Formulation 2; a nuclear counter stain of blue-violet colour. It is extracted from the heartwood of the logwood tree.
Artikel-Nr:
(EHERC10427500)
Lieferant:
EHRENSTORFER
Hersteller-Artikelnummer::
C10427500
Lokale Artikelnummer::
EHERC10427500
Beschreibung:
Kristallviolett
VE:
1 * 0,1 g
Artikel-Nr:
(BOSSBS-11665R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11665R-A555
Lokale Artikelnummer::
BOSSBS-11665R-A555
Beschreibung:
Clathrin-coated pits and vesicles are assembled for receptor-mediated endocytosis through interaction with clathrin associated protein complexes. Vesicle transport is mediated from the trans-Golgi network by the adapter complex AP-1 and from the plasma membrane by the AP-2 complex. The AP-1 and AP-2 adapter protein complexes consist of clathrin binding adaptin proteins and two smaller subunits known as AP50 and AP17. The Alpha- and Beta-Adaptin chains have a similar two-domain organization with C-terminal domains that vary in both sequence and length. Alpha-Adaptin splice variants A and C display variable relative expression levels and differential distribution in different tissues. AP180 (also designated AP-3 or F1-20) is a synapse-specific clathrin assembly protein. The protein CALM (clathrin assembly protein lymphoid myeloid leukemia) is highly homologous to AP180 and may also be involved in clathrin assembly.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11884R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11884R-A488
Lokale Artikelnummer::
BOSSBS-11884R-A488
Beschreibung:
The Drosophila atonal gene produces a protein with basic helix loop helix (bHLH) domains that plays an essential role in the development of the Drosophila nervous system. Mammalian atonal homolog 2 (MATH-2) is a helix-loop-helix (HLH) transcription factor that is structurally homologous to the product of Drosophila atonal gene. MATH-2 is a 337 amino acid protein with an atonal-related basic HLH domain. In mice, expression of MATH-2 takes place by embryonic day 11.5 and initially localizes to the wall of brain vesicles and in the spinal cord. It is expressed in the cortical plate and the mantle layer in the developing central nervous system, and is limited to the nervous system in adults. Adult mouse cerebrums produce a high level of MATH-2 RNA with lower levels in other neuronal tissues. Research studies suggest that MATH-2 may function as a trans-acting factor involved in the development and maintenance of the mammalian nervous system.
VE:
1 * 100 µl
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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