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[4-(1H-Pyrazol-1-yl)phenyl]boronic+acid
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[4-(1H-Pyrazol-1-yl)phenyl]boronic+acid
Lieferant:
Sigma-Aldrich
Beschreibung:
2-Amino-5-pyrimidinboronsäure, Sigma-Aldrich®
Artikel-Nr:
(SIAL654787-5G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
654787-5G
Lokale Artikelnummer::
SIAL654787-5G
Beschreibung:
ω,3-Dibromacetophenon, Sigma-Aldrich®
VE:
1 * 5 g
Artikel-Nr:
(442-9411)
Lieferant:
Bel-Art Products, a Part of SP
Hersteller-Artikelnummer::
F371017814
Lokale Artikelnummer::
BELAF371017814
Beschreibung:
These Spinbar® Pyrex® glass encapsulated Alnico magnet stirring bars are useful for high temperature stirring up to 274 ˚C (525 ˚F).
VE:
1 * 1 ST
Artikel-Nr:
(ABNOMAB9883)
Lieferant:
Abnova
Hersteller-Artikelnummer::
MAB9883
Lokale Artikelnummer::
ABNOMAB9883
Beschreibung:
Mouse monoclonal antibody raised against full length recombinant TPI1.
VE:
1 * 100 µG
Lieferant:
HAMILTON BONADUZ
Beschreibung:
Einsetzbar für Anwendungen wie GC, DC und zum Pipettieren von kleinen Volumina. Konstruiert nach dem totvolumenfreien Prinzip der positiven Verdrängung. Ein feiner Wolframkolben ist dabei durch die gesamte Spitze bis zum Nadelende geführt. Nadel und Wolframkolben sind exakt aufeinander abgestimmt und können gemeinsam ersetzt werden.
Lieferant:
BIONET RESEARCH
Beschreibung:
1-(3-Bromphenyl)pyrrol
Artikel-Nr:
(BOSSBS-1865R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1865R-FITC
Lokale Artikelnummer::
BOSSBS-1865R-FITC
Beschreibung:
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5, TOMM2, USP3, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates 'Lys-63'-linked polyubiquitination of SNCAIP, possibly playing a role in Lewy-body formation. Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy. Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by the ubiquitination of mitochondrial proteins such as TOMM2, RHOT1/MIRO1 and USP3 (PubMed:24896179). Mediates 'Lys-48'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome; possibly playing a role in the regulation of neuron death. Limits the production of reactive oxygen species (ROS). Regulates cyclin-E during neuronal apoptosis. In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress. Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1865R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1865R-CY3
Lokale Artikelnummer::
BOSSBS-1865R-CY3
Beschreibung:
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5, TOMM2, USP3, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates 'Lys-63'-linked polyubiquitination of SNCAIP, possibly playing a role in Lewy-body formation. Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy. Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by the ubiquitination of mitochondrial proteins such as TOMM2, RHOT1/MIRO1 and USP3 (PubMed:24896179). Mediates 'Lys-48'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome; possibly playing a role in the regulation of neuron death. Limits the production of reactive oxygen species (ROS). Regulates cyclin-E during neuronal apoptosis. In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress. Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1865R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1865R-A680
Lokale Artikelnummer::
BOSSBS-1865R-A680
Beschreibung:
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5, TOMM2, USP3, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognised by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates 'Lys-63'-linked polyubiquitination of SNCAIP, possibly playing a role in Lewy-body formation. Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy. Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by the ubiquitination of mitochondrial proteins such as TOMM2, RHOT1/MIRO1 and USP3 (PubMed:24896179). Mediates 'Lys-48'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome; possibly playing a role in the regulation of neuron death. Limits the production of reactive oxygen species (ROS). Regulates cyclin-E during neuronal apoptosis. In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress. Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene.
VE:
1 * 100 µl
Artikel-Nr:
(131-0035)
Lieferant:
VACUUBRAND
Hersteller-Artikelnummer::
20736550
Lokale Artikelnummer::
VACU20736550
Beschreibung:
Der VACUU·SELECT Controller macht Ihre Arbeit einfacher und ermöglicht, dass die VARIO select Chemie-Membranpumpen eine unvergleichliche Präzision liefern. Die Pumpen laufen flüsterleise und reagieren in Echtzeit, indem sie die Drehzahl an die Prozessbedingungen anpassen. Der intuitive VACUU·SELECT Controller bietet vordefinierte Anwendungen für alle gängigen Vakuumprozesse.
VE:
1 * 1 ST
Lieferant:
COMBI-BLOCKS
Beschreibung:
Ethylthiazol-5-carboxylat
Lieferant:
MP Biomedicals
Beschreibung:
1-[(4-Chlorphenyl)(phenyl)methyl]-4-(3-methylbenzyl)piperazindihydrochlorid, weißes Pulver
Artikel-Nr:
(PRSI91-129)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-129
Lokale Artikelnummer::
PRSI91-129
Beschreibung:
Interleukin-20 (IL-20) is a member of the IL-10 family of regulatory cytokines that includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL-20 exhibits approximately 28% amino acid identity with IL-10 and 76% amino acid identity with mouse IL-20. There are two heterodimeric receptor complexes for IL-20. The first is composed of IL-20 R alpha and IL-20 R beta . The second is composed of IL-22 R and IL-20 R beta . Whereas the IL-22 R/IL-20 R beta complex is shared with IL-24, the IL-20 R alpha/IL-20 R beta complex is shared with both IL-19 and IL-24. IL-20 has been shown to initiate transduction cascades involving STAT3 and stimulates the induction of pro-inflammatory genes including TNF- alpha and MCP-1. Initial functional studies using transgenic mice suggest that IL-20 has the ability to regulate skin development. The over-expression of both human and mouse forms of IL-20 results in keratinocyte hyper-proliferation, abnormal epidermal differentiation, and neonatal lethality. In humans, IL-20 and its receptors are up-regulated in psoriatic skin, and polymorphisms in the IL-20 gene have been associated with plaque-type psoriasis. IL-20 may also have a role in hematopoiesis. It enhances the proliferation of multi-potential progenitors in vitro and increases their numbers and cell cycling status in IL-20 transgenic mice. IL-20 is also shown to suppress COX-2 and PGE2 and acts as an inhibitor of angiogenesis in model systems.
VE:
1 * 50 µG
Lieferant:
DELTA T
Beschreibung:
Die SilverBag ist eine preisgünstige Lösung für kurze Transporte. Die SilverBag Serie ist aus stabilem Nylon und Isoliermaterial gefertigt. Die Taschen wurden für die Isolierung von TempShell Elementen konzipiert, die darin passgenau und ohne Platzverlust aufbewahrt werden können.
Artikel-Nr:
(PRSI28-719)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
28-719
Lokale Artikelnummer::
PRSI28-719
Beschreibung:
L-type calcium channels are composed of five subunits. CACNG4 represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family.L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two similar gamma subunit-encoding genes.
VE:
1 * 100 µG
Lieferant:
Sigma-Aldrich
Beschreibung:
(±)-4-Hydroxy-3-methoxymandelsäure, Sigma-Aldrich®
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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