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Ethyl+4-bromo-3-fluorobenzoate
Artikel-Nr:
(BOSSBS-4281R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4281R-A647
Lokale Artikelnummer::
BOSSBS-4281R-A647
Beschreibung:
Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1. Exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4281R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4281R-HRP
Lokale Artikelnummer::
BOSSBS-4281R-HRP
Beschreibung:
Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1. Exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222).
VE:
1 * 100 µl
Artikel-Nr:
(KIMB25656)
Lieferant:
KIMBERLY CLARK
Hersteller-Artikelnummer::
25656
Lokale Artikelnummer::
KIMB25656
Beschreibung:
Ein stilvoller neuer Standard im Augenschutz, der den persönlichen Komfort, die Sicherheit und die Arbeitsleistung verbessert. KLEENGUARD* V20 Comfort Eye Protection bietet verzerrungsfreie Gläser mit bewährtem Stoßschutz, zusätzlichem Komfort und eine große Auswahl an Designs.
VE:
1 * 1 ST
Artikel-Nr:
(431-2897)
Lieferant:
IKA
Hersteller-Artikelnummer::
3646000
Lokale Artikelnummer::
IKAA3646000
Beschreibung:
Dispergiersystem mit hermetisch verschließbaren Einweg-Probenröhrchen. Schützt vor infektiösem Probenmaterial, toxischen oder geruchsintensiven Substanzen. Ideal zur Anwendung im medizinischen, pathologischen, toxikologischen, pharmazeutischen, immunologischen, veterinärmedizinischen und klinischen Bereich sowie in der Lebensmittel- und Kosmetikindustrie. Benutzerfreundliche und schnell einsetzbare Einheiten mit Blockierschutzfunktion für standardisiertes Arbeiten und Einzel- oder Reihenanwendung.
VE:
1 * 1 ST
Artikel-Nr:
(BOSSBS-13492R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13492R-A555
Lokale Artikelnummer::
BOSSBS-13492R-A555
Beschreibung:
The Golgi apparatus is a highly complex organelle comprised of a stack of cisternal membranes on the secretory pathway from the ER to the cell surface. The structure is maintained by an exoskeleton or Golgi matrix constructed from a family of coiled-coil protein, the golgins and other peripheral membrane components such as GRASP55 and GRASP65 (1). GRASP55 (Golgi reassembly stacking protien or p59) is a component of the Golgi stacking machinery. GRASP55 is highly homologous to GRASP65 and contains two PDZ domains. GRASP55 is myristoylated and palmitoylated. Unlike GRASP65, GRASP55 does not have detectable binding with the vesicle docking protein GM130 and is located on the medial-Golgi rather than cis-Golgi. Both GRASP55 and GRASP65 function in the stacking of Golgi Cisternae (2,3). The novel coiled-coil protein golgin 45 interacts with GRASP55 and the GTP form of Rab 2, suggesting that GRASP55 and golgin 45 form a Rab 2 effector complex on medial-Golgi essential for normal protein transport and Golgi structure (4). ERK2 directly phosphorylates GRASP55, which is phosphorylated in mitotic cells, suggesting that mitogen-activated protein kinase kinase (MKK)/ERK pathway phosphorylates the Golgi during mitosis (5).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13492R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13492R-FITC
Lokale Artikelnummer::
BOSSBS-13492R-FITC
Beschreibung:
The Golgi apparatus is a highly complex organelle comprised of a stack of cisternal membranes on the secretory pathway from the ER to the cell surface. The structure is maintained by an exoskeleton or Golgi matrix constructed from a family of coiled-coil protein, the golgins and other peripheral membrane components such as GRASP55 and GRASP65 (1). GRASP55 (Golgi reassembly stacking protien or p59) is a component of the Golgi stacking machinery. GRASP55 is highly homologous to GRASP65 and contains two PDZ domains. GRASP55 is myristoylated and palmitoylated. Unlike GRASP65, GRASP55 does not have detectable binding with the vesicle docking protein GM130 and is located on the medial-Golgi rather than cis-Golgi. Both GRASP55 and GRASP65 function in the stacking of Golgi Cisternae (2,3). The novel coiled-coil protein golgin 45 interacts with GRASP55 and the GTP form of Rab 2, suggesting that GRASP55 and golgin 45 form a Rab 2 effector complex on medial-Golgi essential for normal protein transport and Golgi structure (4). ERK2 directly phosphorylates GRASP55, which is phosphorylated in mitotic cells, suggesting that mitogen-activated protein kinase kinase (MKK)/ERK pathway phosphorylates the Golgi during mitosis (5).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2358R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2358R-A647
Lokale Artikelnummer::
BOSSBS-2358R-A647
Beschreibung:
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
VE:
1 * 100 µl
Artikel-Nr:
(A3480.0025)
Lieferant:
PanReac AppliChem
Hersteller-Artikelnummer::
A3480.0025
Lokale Artikelnummer::
APLIA3480.0025
Beschreibung:
Coomassie Brillantblau G 250
VE:
1 * 25 g
Artikel-Nr:
(MOLE64677156-25G)
Lieferant:
Molekula
Hersteller-Artikelnummer::
64677156-25G
Lokale Artikelnummer::
MOLE64677156-25G
Beschreibung:
Maleimid
VE:
1 * 25 g
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(SIAL143707-100G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
143707-100G
Lokale Artikelnummer::
SIAL143707-100G
Beschreibung:
trans-2,3-Dibrom-2-buten-1,4-diol, Sigma-Aldrich®
VE:
1 * 100 g
Lieferant:
HERAEUS
Beschreibung:
Die CO₂-Inkubatoren der HERAcell® i-Serie sorgen für stabile, genau überwachte Wachstumsbedingungen, die einen unübertroffenen Schutz vor Kontamination bei wertvollen Zell- und Gewebekulturen bieten. Extrem kurze Erholzeiten für CO₂ und Temperatur beschleunigen das Zellwachstum. Die Geräte sind in zwei praktischen Größen und zwei Innenkammer-Ausführungen erhältlich, die entweder aus korrosionsfestem Edelstahl oder zu 100% aus antimikrobiellem massivem Kupfer bestehen. Der Innenraum aus massivem Kupfer verhindert mit natürlichen Mitteln das Wachstum von Bakterien und Pilzen. Die Modelle sind standardmäßig mit hochwertigen Wärmeleitfähigkeitssensoren (TC) ausgestattet.
Artikel-Nr:
(ABCRAB137747.0025)
Lieferant:
ABCR
Hersteller-Artikelnummer::
AB137747.0025
Lokale Artikelnummer::
ABCRAB137747.0025
Beschreibung:
α-Linolensäure
VE:
1 * 25 mL
This is a MarketSource item. Additional charges may apply
Lieferant:
Sigma-Aldrich
Beschreibung:
Dibutylmaleat, Sigma-Aldrich®
Artikel-Nr:
(BOSSBS-11785R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11785R-FITC
Lokale Artikelnummer::
BOSSBS-11785R-FITC
Beschreibung:
Maspardin is a 308 amino acid cytoplasmic protein that is widely expressed. Belonging to the AB hydrolase superfamily, Maspardin colocalizes with CD4 on endosomal/trans-Golgi network. It is thought that Maspardin may act as a negative regulatory factor in CD4-dependent T-cell activation. Defects in the gene encoding Maspardin are the result of hereditary spastic paraplegia autosomal recessive type 21 (also designated Mast syndrome), an autosomal recessive neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. The gene encoding Maspardin is encoded by human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11785R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11785R-A350
Lokale Artikelnummer::
BOSSBS-11785R-A350
Beschreibung:
Maspardin is a 308 amino acid cytoplasmic protein that is widely expressed. Belonging to the AB hydrolase superfamily, Maspardin colocalizes with CD4 on endosomal/trans-Golgi network. It is thought that Maspardin may act as a negative regulatory factor in CD4-dependent T-cell activation. Defects in the gene encoding Maspardin are the result of hereditary spastic paraplegia autosomal recessive type 21 (also designated Mast syndrome), an autosomal recessive neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. The gene encoding Maspardin is encoded by human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome.
VE:
1 * 100 µl
Lieferant:
Alfa Aesar
Beschreibung:
Methylgrün-Zinkchlorid-Doppelsalz
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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