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5-Chloro-1,6-naphthyridine
Artikel-Nr:
(DELT19906)
Lieferant:
DELTALAB
Hersteller-Artikelnummer::
19906
Lokale Artikelnummer::
DELT19906
Beschreibung:
HDPE, white.
VE:
1 * 1 ST
Lieferant:
Heidolph Instruments GmbH & Co.KG
Beschreibung:
Mehrkanal-Pumpenköpfe, Modelle C4, C8 und C12. Kann über das Mehrkanaladapter mit Dispensierpumpenantrieben PD 5001, PD 5101, und PD 5201 betrieben werden. Bis zu 12 Pumpenkanäle können simultan betrieben werden. Separate Dosierung in verschiedene Behälter in einem Arbeitsgang.
Artikel-Nr:
(735-0223)
Lieferant:
Thermo Scientific
Hersteller-Artikelnummer::
150200
Lokale Artikelnummer::
NUNC150200
Beschreibung:
PS, non treated, with lid, sterile.
VE:
1 * 75 ST
Lieferant:
KOEHLER TECHNISCHE PRODUKTEN
Beschreibung:
Made of acrylic, clear.
Lieferant:
DELTALAB
Beschreibung:
PP, square with translucent lid.
Artikel-Nr:
(BOCH5060)
Lieferant:
BOCHEM
Hersteller-Artikelnummer::
5060
Lokale Artikelnummer::
BOCH5060
Beschreibung:
Tempered cast iron, green varnished.
VE:
1 * 1 ST
Artikel-Nr:
(BOSSBS-13140R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13140R-A488
Lokale Artikelnummer::
BOSSBS-13140R-A488
Beschreibung:
Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromsomal instability (1,2). The FA Group C complementation group gene encodes the protein FANCC, which is located in both cytoplasmic and nuclear compartments. FANCC is expressed in a cell cycle-dependent manner, with the lowest levels at the G1/S boundary and the highest levels in the M-phase. The FANCC protein interacts with other FA complementation group proteins as well as non-FA proteins (3). A human a spectrin II (designated aSpIIs) acts as a scaffold to enhance interactions between FANCC and FANCA to form a nuclear complex (4,5). Another binding partner of FANCC is the BTB/POZ domain containing protein FAZF, which is a transcriptional repressor (6). In hematopoietic cells expressing mutant FANCC, PKR is constitutively phosphorylated and has increased binding affinity for double-stranded RNA (7,8), which suggests that FANCC indirectly suppresses the activity of PKR. These cells are also apoptotic and are hypersensitive to IFNg and TNFa (8). In addition, FANCC protein is involved in the activation of STAT1 through receptors for at least three hematopoietic growth and survival factors (8).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11607R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11607R-A680
Lokale Artikelnummer::
BOSSBS-11607R-A680
Beschreibung:
The leucine-rich (LRR) repeat is a 20 to 30 amino acid motif that forms a hydrophobic / horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. LRRC54 (leucine-rich repeat-containing protein 54), also known as tsukushin, TSKU or E2-induced gene 4 protein (E2IG4), is a 353 amino acid secreted protein that likely localizes to the cell membrane and extracellular compartments. Involved in extracellular secretion and intracellular transport, LRRC54 can be induced by 17-beta-estradiol. Containing nine LRR repeat and a cleavable signal peptide, the gene encoding LRRC54 maps to human chromosome 11, which houses over 1400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13140R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13140R-A647
Lokale Artikelnummer::
BOSSBS-13140R-A647
Beschreibung:
Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromsomal instability (1,2). The FA Group C complementation group gene encodes the protein FANCC, which is located in both cytoplasmic and nuclear compartments. FANCC is expressed in a cell cycle-dependent manner, with the lowest levels at the G1/S boundary and the highest levels in the M-phase. The FANCC protein interacts with other FA complementation group proteins as well as non-FA proteins (3). A human a spectrin II (designated aSpIIs) acts as a scaffold to enhance interactions between FANCC and FANCA to form a nuclear complex (4,5). Another binding partner of FANCC is the BTB/POZ domain containing protein FAZF, which is a transcriptional repressor (6). In hematopoietic cells expressing mutant FANCC, PKR is constitutively phosphorylated and has increased binding affinity for double-stranded RNA (7,8), which suggests that FANCC indirectly suppresses the activity of PKR. These cells are also apoptotic and are hypersensitive to IFNg and TNFa (8). In addition, FANCC protein is involved in the activation of STAT1 through receptors for at least three hematopoietic growth and survival factors (8).
VE:
1 * 100 µl
Artikel-Nr:
(PROOMM0491.02)
Lieferant:
LGC Standards PROMOCHEM
Hersteller-Artikelnummer::
MM0491.02
Lokale Artikelnummer::
PROOMM0491.02
Beschreibung:
Organic Standard, 3-[2-[4-[(Z)-(2,4-difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
VE:
1 * 100 mg
Lieferant:
Avantor Fluid Handling
Beschreibung:
Ideal for most acid/base or ionic salt applications.
Artikel-Nr:
(229-0747)
Lieferant:
KARTELL
Hersteller-Artikelnummer::
71415
Lokale Artikelnummer::
KART71415
Beschreibung:
PP, durchscheinend
VE:
1 * 10 ST
Artikel-Nr:
(SIAL19671-100G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
19671-100G
Lokale Artikelnummer::
SIAL19671-100G
Beschreibung:
4-tert-Butylbrenzcatechin, Sigma-Aldrich®
VE:
1 * 100 g
Lieferant:
HAMILTON BONADUZ
Beschreibung:
Loses Sorbents auf Polymer basis für die Anionaustauch-chromatographie.
Artikel-Nr:
(BOSSBS-9461R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9461R-A488
Lokale Artikelnummer::
BOSSBS-9461R-A488
Beschreibung:
The LIN-12/Notch family of transmembrane receptors plays a central role in development by regulating cell fate and establishing boundaries of gene expression. Notch signaling activates the Hairy/Enhancer of split (HES) genes, which encode basic helix-loop-helix (bHLH) transcriptional repressors that are critical for directing embryonic patterning and development. The Hairy-related transcription factors (HRTs) comprise a subclass of bHLH proteins that exhibit structural similarity with the HES proteins and include HRT1, HRT2 and HRT3. The HRT family (also designated Hesr, Hey, CHF and Gridlock) contain a bHLH domain, an Orange domain and a novel YRPW domain, which is absent in HRT3. The Hairy-related genes map to human chromosomes 8q21, 6q21 and 1p34.3 for HRT1, HRT2 and HRT3, respectively, and are downstream targets for Notch signaling. HRT1 is expressed in the somitic mesoderm, central nervous system, kidney, heart, nasal epithelium and limb buds in murine embryos as well as in adult tissues. It has altered expression in many breast, lung and kidney tumors. Like HRT1, HRT2 and HRT3 are also expressed in developing somites, heart and nervous system.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3730R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3730R
Lokale Artikelnummer::
BOSSBS-3730R
Beschreibung:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. There have been at least 12 different PKC isoforms identified in humans to date including alpha, beta I, beta II, gamma, delta, epsilon, zeta, eta, theta, iota, lambda, and mu. PKC gamma is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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