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5-Brom-2-fluor-4-nitrotoluol
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5-Brom-2-fluor-4-nitrotoluol
Artikel-Nr:
(BOSSBS-0806R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0806R-A555
Lokale Artikelnummer::
BOSSBS-0806R-A555
Beschreibung:
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4587R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4587R-A488
Lokale Artikelnummer::
BOSSBS-4587R-A488
Beschreibung:
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5046R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5046R-A350
Lokale Artikelnummer::
BOSSBS-5046R-A350
Beschreibung:
The Cyp46 gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed exclusively in the brain, where it converts cholesterol to 24S-hydroxycholesterol by adding a hydroxyl group to cholesterol, producing a product that is more soluble than cholesterol and able to be exported from the brain.Cyp46 is also known as 24S-cholesterol hydroxylase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0367G-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0367G-A488
Lokale Artikelnummer::
BOSSBS-0367G-A488
Beschreibung:
The complement factor C3 consists of an alpha and a beta chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical mannose binding lectin activation pathway leads to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a and C3b. Further degradation leads to the formation of the alpha chain products C3d, C3g and C3c. C3 is an acute phase protein that is produced by a wide range of tissues, including renal epithelial cells and hepatocytes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5145R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5145R-A488
Lokale Artikelnummer::
BOSSBS-5145R-A488
Beschreibung:
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5032R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5032R-A555
Lokale Artikelnummer::
BOSSBS-5032R-A555
Beschreibung:
Agpat2 is a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. It is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in its have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6867R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6867R-A647
Lokale Artikelnummer::
BOSSBS-6867R-A647
Beschreibung:
The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5120R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5120R-A488
Lokale Artikelnummer::
BOSSBS-5120R-A488
Beschreibung:
Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes and the endoplasmic reticulum.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2702R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2702R-A350
Lokale Artikelnummer::
BOSSBS-2702R-A350
Beschreibung:
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3562R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3562R-A488
Lokale Artikelnummer::
BOSSBS-3562R-A488
Beschreibung:
The NFKB complex consists of NFKB1 or NFKB2 bound to REL, RELA, or RELB. The NFKB complex is inhibited by I kappa B proteins (NFKBIA, or NFKBIB), which inactivate NF kappa B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I kappa B proteins by kinases (IKBKA, or IKBKB,) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF kappa B complex. For some genes, activation requires NFKB interaction with other transcription factors, such as STAT, AP1 (JUN), and NFAT.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2891R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2891R-A350
Lokale Artikelnummer::
BOSSBS-2891R-A350
Beschreibung:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4874R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4874R-A647
Lokale Artikelnummer::
BOSSBS-4874R-A647
Beschreibung:
The complement factor C3 consists of an alpha and a beta chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical mannose binding lectin activation pathway leads to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a and C3b. Further degradation leads to the formation of the alpha chain products C3d, C3g and C3c. C3 is an acute phase protein that is produced by a wide range of tissues, including renal epithelial cells and hepatocytes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2923R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2923R-A680
Lokale Artikelnummer::
BOSSBS-2923R-A680
Beschreibung:
Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganisation of nuclear speckles during mitosis. Hyperphosphorylates RS domain-containing proteins such as SFRS1, SFRS2 and ZRSR2 on serine residues during metaphase but at lower levels during interphase. Locks onto SFRS1 to form a stable complex and processively phosphorylates the RS domain. Appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8287R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8287R-A555
Lokale Artikelnummer::
BOSSBS-8287R-A555
Beschreibung:
Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyzes the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.Tissue specificity:Liver and kidney.Involvement in disease:Defects in DPYS are the cause of dihydropyrimidinase deficiency (DHPD). DHPD is an autosomal recessive disorder characterized by dihydropyrimidinuria and associated with a variable clinical phenotype: epileptic or convulsive attacks, dysmorphic features and severe developmental delay, and congenital microvillous atrophy.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3489R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3489R-A488
Lokale Artikelnummer::
BOSSBS-3489R-A488
Beschreibung:
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11681R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11681R-A750
Lokale Artikelnummer::
BOSSBS-11681R-A750
Beschreibung:
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an endoprotease complex that catalyses the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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