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5-Brom-2-fluor-4-nitrotoluol
Artikel-Nr:
(BOSSBS-8319R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8319R-A488
Lokale Artikelnummer::
BOSSBS-8319R-A488
Beschreibung:
LHPP, also known as HDHD2B, is a 270 amino acid protein that exists as a homodimer and is a member of the HAD-like hydrolase superfamily. Expressed in liver, kidney and moderately in brain, LHPP is encoded by a gene located on 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11802R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11802R-A350
Lokale Artikelnummer::
BOSSBS-11802R-A350
Beschreibung:
The organic anion transporter family of proteins mediate hepatic uptake of cardiac glycosides. OATP-D is a 710 amino acid member of the organic anion transporter protein family. As a multi-pass membrane protein, OATP-D mediates the Na+-independent transport of vasopressin, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II and other organic anions, but not estrone-3-sulfate, DPDPE, taurocholate, DHEAS or digoxin. OATP-D is ubiquitously expressed with highest levels present in leukocytes and spleen. OATP-D is expressed as four isoforms produced by alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0733R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0733R-A555
Lokale Artikelnummer::
BOSSBS-0733R-A555
Beschreibung:
Metalloprotease that may play a role in the degradation of COMP. Binds 1 zinc ion per subunit. pH dependence: Optimum pH is between 7.5 and 9.5. [Subcellular location] Secreted, extracellular space, extracellular matrix (By similarity). Note=Also found associated with the external cell surface[Tissue specificity] Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Detected in meniscus, bone, tendon, cartilage, synovium, fat and ligaments. Up-regulated in articular cartilage and synovium from arthritis patients.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5672R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5672R-A488
Lokale Artikelnummer::
BOSSBS-5672R-A488
Beschreibung:
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12040R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12040R-A647
Lokale Artikelnummer::
BOSSBS-12040R-A647
Beschreibung:
alpha2C-adrenergic receptors (alpha2C-AR) regulate neurotransmitter release from sympathetic nerves in the heart, and from adrenergic neurons in the central nervous system. alpha2C-AR can influence Parkinson’s disease, panic disorders, and Huntington disease (HD) progression. A genetic variant in the alpha2C-AR coding region (Del322-325) renders the receptor partially uncoupled from Gi, and is a contributing risk factor for heart failure. alpha2C-AR transcripts are present in rat muscle, heart, pancreas, and kidney.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6107R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6107R-A488
Lokale Artikelnummer::
BOSSBS-6107R-A488
Beschreibung:
Has both helicasee and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0516R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0516R-A488
Lokale Artikelnummer::
BOSSBS-0516R-A488
Beschreibung:
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9669R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9669R-A350
Lokale Artikelnummer::
BOSSBS-9669R-A350
Beschreibung:
DENND4C is a 1,673 amino acid multi-pass membrane protein. DENND4C contains a dDENN domain, DENN domain, uDENN domain and a PPR (pentatricopeptide) repeat. As a result of alternative splicing, six DENND4C isoforms exist. The gene encoding DENND4C maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9. Notably, chromosome 9 encompasses the largest interferon family gene cluster.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12343R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12343R-A555
Lokale Artikelnummer::
BOSSBS-12343R-A555
Beschreibung:
TRB-1 is a 372 amino acid protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase superfamily. Expressed ubiquitously with highest expression in bone marrow, thyroid gland, skeletal muscle and pancreas, TRB-1 interacts with MAPK kinases and is thought to regulate the activation of MAP kinses, possibly controlling MAP kinase cascades. The gene encoding TRB-1 maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13283R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13283R-A555
Lokale Artikelnummer::
BOSSBS-13283R-A555
Beschreibung:
GAPVD1 is a 1478 amino acid peripheral membrane protein that acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF). GAPVD1 participates in many processes such as insulin receptor internalization, Glut4 trafficking and endocytosis. In addition, depletion of GAPVD1 leads to delayed EGFR degradation by mediating receptor ubiquination through its RGD domain, suggesting that it may be an important mediator of carcinogenesis resulting from Ras protein mutations. There are six isoforms of GAPVD1 that are produced as a result of alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11716R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11716R-A350
Lokale Artikelnummer::
BOSSBS-11716R-A350
Beschreibung:
CRBN is a 442 amino acid protein which is highly concentrated in human brain tissue. CRBN functions are thought to be related to energy metabolism, learning and memory. Localized to the cytoplasm, CRBN acts as a protease in mitochondria and is thought to regulate the assembly of KCNT1, as well as the surface expression of KCNT1 in brain regions known to affect memory and learning, such as the hippocampus. The gene encoding CRBN belongs to a family of ATP-dependent lon proteases that play a role in membrane trafficking and proteolysis. Defects in the CRBN gene are associated with mild mental retardation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11125R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11125R-A647
Lokale Artikelnummer::
BOSSBS-11125R-A647
Beschreibung:
This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor, retinal degeneration slow (RDS). It is essential for disk morphogenesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9719R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9719R-A555
Lokale Artikelnummer::
BOSSBS-9719R-A555
Beschreibung:
The PDE4A8 is a testis germ cell-specific PDE4A variant. There are two PDE4A variants identified in rat testis (PDE4A8 and an un-characterized 76 kDa PDE4A protein). Spermatogenesis is accompanied by expression of a varied repertoire of PDE4 enzymes at different stages of cell differentiation that presumably perform specialized functions. Confocal microscopic examination revealed the presence of PDE4A8 in primary and secondary spermatids but not in mature spermatozoa. PDE4A8 inhibition results in increased apoptosis of the germ cells accompanied with reduction in the number of mature spermatozoa.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8582R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8582R-A555
Lokale Artikelnummer::
BOSSBS-8582R-A555
Beschreibung:
Glycosyltransferases that mediate the regio- and stereoselective transfer of sugars, such as the fucosyltransferases, determine cell surface-carbohydrate profiles, which is an essential interface for biological recognition processes. GTDC1 (Glycosyltransferase-like domain-containing protein 1), also known as Mat-Xa, is a 458 amino acid protein belonging to the glycosyltransferase 1 family. GTDC1 is ubiquitously expressed, with highest levels found in peripheral blood leukocytes, spleen, lung and testis.An extremely rare recessive genetic disorder, Alstré°‰ syndrome, is caused by mutations in the ALMS1 gene, which maps to chromosome 2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11171R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11171R-A750
Lokale Artikelnummer::
BOSSBS-11171R-A750
Beschreibung:
Neurexophilin family (Neurexophilin-1-4) of neuropeptide-like glycoproteins that are proteolytically processed after synthesis. Neurexophilin-1-3 are secreted proteins that are thought to function as Signalling molecules which specifically bind to target proteins, such as neurexin I?(a protein that promotes adhesion between dendrites and axons), and are essential for proper neurotransmitter release. While Neurexophilin-1 is located primarily in spleen tissue, Neurexophilin-2 is expressed primarily in kidney and both Neurexophilin-2 and Neurexophilin-3 are highly expressed in brain. Defects in the gene encoding Neurexophilin-1 may be associated with schizophrenia, a mental disorder characterised by an abnormal perception of reality.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1193R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1193R-A750
Lokale Artikelnummer::
BOSSBS-1193R-A750
Beschreibung:
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
VE:
1 * 100 µl
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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