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5-Brom-2-fluor-4-nitrotoluol
Artikel-Nr:
(BOSSBS-0278R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0278R-A680
Lokale Artikelnummer::
BOSSBS-0278R-A680
Beschreibung:
Human Rad1 is a component of a heterotrimeric PCNA like complex that also contains the Rad9 and Hus1 proteins. This complex is believed to be involved in cellular responses to DNA damage, possibly by associating with Rad17 and several components of the PCNA-loading heteropentamer, replication factor C. Human Rad1 exhibits significant homology to Rad1 from S. pombe, and its expression in yeast rad1 mutants has been shown to partially restore radiation resistance and G2 checkpoint activity. It has also been shown to possess exonuclease activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6715R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6715R-A750
Lokale Artikelnummer::
BOSSBS-6715R-A750
Beschreibung:
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3395R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3395R-A647
Lokale Artikelnummer::
BOSSBS-3395R-A647
Beschreibung:
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13328R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13328R-A680
Lokale Artikelnummer::
BOSSBS-13328R-A680
Beschreibung:
Gemin4 is a component of the SMN core complex which, while in the cytoplasm, plays an essential role in ribonucleoprotein (snRNP) assembly, including the biogenesis, delivery and recycling of snRNPs to the spliceosome. In the nucleus, where SMN is required for pre-mRNA splicing, Gemin4 concentrates next to coiled bodies in subnuclear structures called gems, that are highly enriched in splicosomal snRNPs, and in the nucleolus. Deletion or loss-of-function mutations in the SMN lead to the neurodegenerative disease spinal muscular atrophy (SMA). The human Gemin4 maps to chromosome 17p13.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5045R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5045R-A555
Lokale Artikelnummer::
BOSSBS-5045R-A555
Beschreibung:
The protein encoded by this gene, a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene. [provided by RefSeq, Jun 2009].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3818R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3818R-A488
Lokale Artikelnummer::
BOSSBS-3818R-A488
Beschreibung:
Growth differentiation factor 15 (GDF15) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. It has been implicated in a variety of functions directly related to tumorigenicity including antiproliferative and pro-apoptotic effects. BMP proteins are secreted growth factors that are characterized by seven conserved cysteine residues. In general, they are regulators of cell growth and differentiation in both embryonic and adult tissues.GDF15 is an important downstream mediator of DNA damage signaling and a transcriptional target of p53.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3891R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3891R-A488
Lokale Artikelnummer::
BOSSBS-3891R-A488
Beschreibung:
This gene encodes neutrophil cytosolic factor 2, the67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9441R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9441R-A750
Lokale Artikelnummer::
BOSSBS-9441R-A750
Beschreibung:
The downstream regulatory element, DRE, acts as a location-dependent gene silencer. DREAM (for DRE-antagonist modulator) is a Ca²⁺ regulated transcriptional repressor that specifically binds to the DRE. DREAM regulates transcription of prodynorphin and c-Fos genes and shows 99% nucleotide homology to the Kv channel-interacting proteins (KChIPs). KChIP family members include KChIP1, which is expressed in brain, KChIP2, which is expressed in heart, brain, and lung, KChIP3 (also designated calsenilin), which is expressed in brain and testis and KChIP4.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1693R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1693R-A488
Lokale Artikelnummer::
BOSSBS-1693R-A488
Beschreibung:
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0806R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0806R-A350
Lokale Artikelnummer::
BOSSBS-0806R-A350
Beschreibung:
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3561R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3561R-A750
Lokale Artikelnummer::
BOSSBS-3561R-A750
Beschreibung:
Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcriptional activity of the nuclear receptor with which they associate. One such coactivator is KAT13C / nuclear receptor coactivator 2 (NCOA2), also termed Glucocorticoid receptor-interacting protein 1 (GRIP1).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5990R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5990R-A488
Lokale Artikelnummer::
BOSSBS-5990R-A488
Beschreibung:
This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7688R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7688R-A488
Lokale Artikelnummer::
BOSSBS-7688R-A488
Beschreibung:
This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5077R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5077R-A647
Lokale Artikelnummer::
BOSSBS-5077R-A647
Beschreibung:
LASS2 (LAG1 homolog, ceramide synthase 2) has sequence similarity to yeast longevity assurance gene 1. It is thought to be involved in sphingolipid synthesis. Expression of LASS2 is transiently increased during the period of active myelination and is specifically localized to white matter tracts of the brain, including the Schwann cells of sciatic nerves suggesting that LASS2 is important for the synthesis of dihydroceramide used for synthesis of myelin sphingolipids. Expression of LASS2 in hepatocellular carcinoma cell lines suppresses the growth of cancer cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1990R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1990R-A750
Lokale Artikelnummer::
BOSSBS-1990R-A750
Beschreibung:
Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6325R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6325R-A750
Lokale Artikelnummer::
BOSSBS-6325R-A750
Beschreibung:
Defects in SLC2A10 are the cause of arterial tortuosity syndrome (ATS) [MIM:208050]. ATS is an autosomal recessive disorder characterised by tortuosity and elongation of major arteries, often resulting in death at young age. Other typical features include aneurysms of large arteries and stenosis of the pulmonary artery, in association with facial features and several connective tissue manifestations such as soft skin and joint laxity. Histopathological findings include fragmentation of elastic fibers in the tunica media of large arteries.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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