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6,7-Dimethylchinolin-2,3-dicarbons\u00E4ure
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6,7-Dimethylchinolin-2,3-dicarbons\u00E4ure
Lieferant:
BACHEM BIOCHEMICA
Beschreibung:
E-64
Artikel-Nr:
(PIERA35394)
Lieferant:
Thermo Scientific
Hersteller-Artikelnummer::
A35394
Lokale Artikelnummer::
PIERA35394
Beschreibung:
Thermo Scientific Pierce SMCC is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7–9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5–7.5 to form stable thioether bonds. In aqueous solutions, NHS ester hydrolytic degradation is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group, but will slowly hydrolyze and lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugations with these crosslinkers are usually performed at pH 7.2–7.5, with the NHS ester (amine-targeted) reacted before or simultaneous with the maleimide (sulfhydryl-targeted) reaction.
VE:
1 * 10 mg
Artikel-Nr:
(HONCR1650-10MG)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
R1650-10MG
Lokale Artikelnummer::
HONCR1650-10MG
Beschreibung:
High quality organic reference materials produced according to ISO 9001.
VE:
1 * 10 mg
Artikel-Nr:
(BACE4027912.0001)
Lieferant:
BACHEM BIOCHEMICA
Hersteller-Artikelnummer::
4027912.0001
Lokale Artikelnummer::
BACE4027912.0001
Beschreibung:
E-64C
VE:
1 * 1 mg
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(MOLEM17692553)
Lieferant:
Molekula
Hersteller-Artikelnummer::
M17692553
Lokale Artikelnummer::
MOLEM17692553
Beschreibung:
Acridinorange (Zinkchlorid-Doppelsalz)
VE:
1 * 25 g
This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(PIER22360)
Lieferant:
Thermo Scientific
Hersteller-Artikelnummer::
22360
Lokale Artikelnummer::
PIER22360
Beschreibung:
Thermo Scientific Pierce SMCC is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7–9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5–7.5 to form stable thioether bonds. In aqueous solutions, NHS ester hydrolytic degradation is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group, but will slowly hydrolyze and lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugations with these crosslinkers are usually performed at pH 7.2–7.5, with the NHS ester (amine-targeted) reacted before or simultaneous with the maleimide (sulfhydryl-targeted) reaction.
VE:
1 * 50 mg
Artikel-Nr:
(SERA10665.02)
Lieferant:
Serva
Hersteller-Artikelnummer::
10665.02
Lokale Artikelnummer::
SERA10665.02
Beschreibung:
Acridinorange (Zinkchlorid-Doppelsalz)
VE:
1 * 50 g
This is a MarketSource item. Additional charges may apply
Lieferant:
Cayman Chemical
Beschreibung:
Lupeol, a dietary triterpene found in certain fruits, vegetables, and medicinal plants, has potent anti-inflammatory, anticarcinogenic, antimutagenic, and antimalarial activity. It suppresses the growth of hepatocellular carcinoma cell lines SMMC7721 and HepG2 with IC50 values of 45 and 48.5 μM and melanoma cell lines Mel 928 and Mel 1241 with IC50 values of 75 and 72 μM.¹'² At 0.76 g/kg lupeol causes a significant decrease in the blood pressure of stroke-prone hypertensive rats and reduces expression of hepatic genes involved in triglyceride and cholesterol synthesis.³ It also has significant anti-inflammatory effects at 50 mg/kg in a carrageenan-induced edema model, inhibiting neutrophil migration.⁴
1. Tarapore, R.S.,Siddiqui, I.A.,Saleem, M., et al. Specific targeting of Wnt/β-catenin signaling in human melanoma cells by a dietary triterpene lupeol. Carcinogenesis 31(10), 1844-1853 (2010). 2. He, Y.,Liu, F.,Zhang, L., et al. Growth inhibition and apoptosis induced by lupeol, a dietary triterpene, in human hepatocellular carcinoma cells. Bio.Pharm.Bull. 34(4), 517-522 (2011). 3. Ardiansyah,Yamaguchi, E.,Shirakawa, H., et al. Lupeol supplementation improves blood pressure and lipid metabolism parameters in stroke-prone spontaneously hypertensive rats. Bioscience, Biotechnology, and Biochemistry 76(1), 183-185 (2012). 4. Lucetti, D.L.,Lucetti, E.C.,Bandeira, M.A., et al. Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel. Journal of Inflammation 7(60), 1-11 (2010).
Lieferant:
Alfa Aesar
Beschreibung:
Diethylenglycolmonohexylether ≥97%
Lieferant:
Alfa Aesar
Beschreibung:
N,N-Dimethyl-1,4-phenylendiammoniumdichlorid 98%
Artikel-Nr:
(470792500.)
Lieferant:
Thermo Scientific
Hersteller-Artikelnummer::
470792500
Lokale Artikelnummer::
ACRO470792500
Beschreibung:
Mitoxantrone dihydrochloride 97%
VE:
1 * 250 mg
New Product
Lieferant:
MP Biomedicals
Beschreibung:
Sesame oil is a potent antioxidant, which can inhibit DNA damage and lipid peroxidation by 4-Nitroquinoline N-oxide in rats.
Artikel-Nr:
(PRSI92-588)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-588
Lokale Artikelnummer::
PRSI92-588
Beschreibung:
Interleukin-15 receptor subunit alpha, also known as Il15ra, is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, or gamma c) to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells. Human Il15ra shares 45% amino acid sequence homology with the mouse form of the receptor. Eight isoforms of IL-15 R alpha mRNA have been identified, resulting from alternative splicing events involving different exons.Interleukin 15 (IL-15) is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL15 receptor (IL-15RA) with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other's activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs.
VE:
1 * 50 µG
Lieferant:
Sigma-Aldrich
Beschreibung:
Acridinorange (Zinkchlorid-Doppelsalz), Sigma-Aldrich®
Artikel-Nr:
(PROOCON150-100-265)
Lieferant:
LGC Standards PROMOCHEM
Hersteller-Artikelnummer::
CON150-100-265
Lokale Artikelnummer::
PROOCON150-100-265
Beschreibung:
Iron Standard, 1000 µg/g, CONOSTAN®, Eisen, Matrix: Öl, Anwendung: Ölbasierende Standards
VE:
1 * 50 g
Artikel-Nr:
(J60080.AK)
Lieferant:
Alfa Aesar
Hersteller-Artikelnummer::
J60080.AK
Lokale Artikelnummer::
ALFAJ60080.AK
Beschreibung:
Cloning Buffer, TRIS Pufferlösung pH 8 (1 mol/l)
VE:
1 * 250 mL
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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