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5-Bromothiophen-2-amine,+N-BOC+protected
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5-Bromothiophen-2-amine,+N-BOC+protected
Artikel-Nr:
(BOSSBS-12928R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12928R-CY7
Lokale Artikelnummer::
BOSSBS-12928R-CY7
Beschreibung:
The cytochrome P450 proteins (CYPs) are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP26A1 is a major retinoic acid catabolic enzyme. CYP26A1 plays an important role in protecting tailbud tissues from inappropriate exposure to retinoic acid. CYP26A1 transcription is epigenetically regulated by nuclear retinoic acid receptor ∫2. Mutations in the gene encoding for CYP26A1 are associated with caudal agenesis and spina bifida, imperforate anus, agenesis of the caudal portions of the digestive and urogenital tracts, and malformed lumbosacral skeletal elements. CYP26A1 is upregulated in adenomatous polyposis coli mouse adenomas, human FAP adenomas, human sporadic colon carcinomas, and in the intestine of adenomatous polyposis coli (apcmcr) mutant zebrafish embryos.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8333R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8333R-CY5
Lokale Artikelnummer::
BOSSBS-8333R-CY5
Beschreibung:
RDH13, also known as all-trans and 9-cis retinol dehydrogenase 13 or SDR7C3, is a 331 amino acid mitochondrial protein belonging to the short-chain dehydrogenases/reductases (SDR) family. Widely expressed, mostly in eye, pancreas, placenta and lung, RDH13 localizes on the outer side of the inner mitochondrial membrane. Related to microsomal retinoid oxidoreductase RDH11, RDH13 is considered to be a major enzyme among the RDH family of proteins. Catalytically active, RDH13 recognizes retinoids as substrates and may function in retinoic acid production. RDH13 may function to protect the mitochondria against oxidative stress. Leber congenital amaurosis (LCA) type 3, an inherited autosomal recessive retinal disease, has been associated with defects of RDH13. LCA represents the most common genetic cause of congenital visual impairment in infants and children.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8333R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8333R-CY3
Lokale Artikelnummer::
BOSSBS-8333R-CY3
Beschreibung:
RDH13, also known as all-trans and 9-cis retinol dehydrogenase 13 or SDR7C3, is a 331 amino acid mitochondrial protein belonging to the short-chain dehydrogenases/reductases (SDR) family. Widely expressed, mostly in eye, pancreas, placenta and lung, RDH13 localizes on the outer side of the inner mitochondrial membrane. Related to microsomal retinoid oxidoreductase RDH11, RDH13 is considered to be a major enzyme among the RDH family of proteins. Catalytically active, RDH13 recognizes retinoids as substrates and may function in retinoic acid production. RDH13 may function to protect the mitochondria against oxidative stress. Leber congenital amaurosis (LCA) type 3, an inherited autosomal recessive retinal disease, has been associated with defects of RDH13. LCA represents the most common genetic cause of congenital visual impairment in infants and children.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9095R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9095R-CY7
Lokale Artikelnummer::
BOSSBS-9095R-CY7
Beschreibung:
Members of the class-III pyridoxal-phosphate-dependent aminotransferase family, such as AGXT2, catalyze the conversion of glyoxylate to glycine using L-alanine as the amino donor. AGXT2 protects from asymmetric dimethylarginine (ADMA)-induced inhibition in nitric oxide (NO) production. Elevated blood concentrations of ADMA, a methyl derivate of the amino acid arginine and an endogenous inhibitor of nitric oxide (NO) synthase, is produced by the physiological degradation of methylated proteins and is found in association with diabetes, hypertension, congestive heart failure and atherosclerosis. AGXT2L2 (alanine-glyoxylate aminotransferase 2-like 2) is a 450 amino acid pyridoxal phosphate that exists as a homotetramer. Belonging to the class-III pyridoxal-phosphate-dependent aminotransferase family, AGXT2L2 localizes to the mitochondria and exists as three alternatively spliced isoforms. Encoded by a gene located on human chromosome 5q35.3, AGXT2L2 may have similar functions as AGXT2.
VE:
1 * 100 µl
Lieferant:
MP Biomedicals
Beschreibung:
Histamine Diphosphate Monohydrate is potent vasodilater.
Lieferant:
Honeywell Chemicals
Beschreibung:
Ameisensäure 49 - 51% (durch titrimetrische Analyse) in Wasser, Puriss. p.a. für die HPLC, Fluka™
Lieferant:
ANSELL HEALTH CARE
Beschreibung:
Diese Handschuhe mit Rollbündchen bestehen aus durchstichfestem Nitril, das einen großartigen Schutz gegen versehentliche Spritzer gefährlicher Chemikalien bietet.
Artikel-Nr:
(COBBPN-6045-1G)
Lieferant:
COMBI-BLOCKS
Hersteller-Artikelnummer::
PN-6045-1G
Lokale Artikelnummer::
COBBPN-6045-1G
Beschreibung:
2-(4-Methoxybenzylamino)-5-pyrimidinboronsäurepinakolester
VE:
1 * 1 g
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(COBBPN-5925-1G)
Lieferant:
COMBI-BLOCKS
Hersteller-Artikelnummer::
PN-5925-1G
Lokale Artikelnummer::
COBBPN-5925-1G
Beschreibung:
2-(Butylamino)-5-pyrimidinboronsäurepinakolester
VE:
1 * 1 g
This is a MarketSource item. Additional charges may apply
Lieferant:
VWR Collection
Beschreibung:
Diese 106,7 µm starken Vinyl-Filme mit einer Klebeschicht von 20 µm schützen Proben in 96-Well-Platten vor Kontamination und Verdunstung.
Artikel-Nr:
(SIAL707341-1G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
707341-1G
Lokale Artikelnummer::
SIAL707341-1G
Beschreibung:
2-Amino-3-fluorpyridin, Sigma-Aldrich®
VE:
1 * 1 g
Artikel-Nr:
(BOSSBS-13399R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13399R-A680
Lokale Artikelnummer::
BOSSBS-13399R-A680
Beschreibung:
Members of the glutathione S-transferase (GST) family of proteins function in the detoxification of xenobiotics to protect cells against toxicant-induced damage. There are eight families of GST proteins, namely alpha, zeta, theta, kappa, mu, pi, sigma and omega, each of which are composed of proteins that have a variety of functions throughout the cell. GSTK1 (glutathione S-transferase kappa 1), also known as glutathione S-transferase subunit 13 (GST 13-13) or GSTK1-1, is a 226 amino acid ubiquitously expressed protein belonging to the kappa class of the GST superfamily that functions in cellular detoxification. Localizing to peroxisome, GSTK1 exists as a homodimer that catalyzes the conjugation of glutathione to a number of hydrophobic substrates leading to their removal from the cell.
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
Di-tert-butylpyrocarbonat
Lieferant:
Sigma-Aldrich
Beschreibung:
4-Amino-1-benzylpiperidin, Sigma-Aldrich®
Artikel-Nr:
(BOSSBS-4216R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4216R-A350
Lokale Artikelnummer::
BOSSBS-4216R-A350
Beschreibung:
Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3325R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3325R-A488
Lokale Artikelnummer::
BOSSBS-3325R-A488
Beschreibung:
PAR4 is a member of a unique family of GPCRs, the proteinase-activated receptors (PARs), that are activated by proteolytic cleavage of the N-terminal domain of the receptor to reveal a tethered ligand. The PAR family consists of 4 receptors; PAR1 and PAR3 are activated by thrombin, and PAR2 and PAR4 are activated by several serine proteases (Macfarlane et al., 2001). PAR4 is expressed along with PAR1 on human platelets, and each plays an important role in thrombin-induced platelet aggregation (Holinstat et al., 2006). However, platelets from mice express PAR4 but not PAR1, and platelets from mice lacking PAR4 fail to aggregate in response to thrombin (Sambrano et al., 2001). Mice lacking PAR4 are protected from mesenteric arteriole thrombosis, indicating that PAR4 is a potential target for treatment of thrombosis in humans.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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