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(R)-(+)-2-Pyrrolidinon-5-carbons\\u00E4ure
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(R)-(+)-2-Pyrrolidinon-5-carbons\\u00E4ure
Artikel-Nr:
(BOSSBS-2361R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2361R-CY5.5
Lokale Artikelnummer::
BOSSBS-2361R-CY5.5
Beschreibung:
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
VE:
1 * 100 µl
Lieferant:
Hichrom Limited
Beschreibung:
Vydac TP ist die erste im Vydac-Sortiment entwickelte Reihe weitporiger Medienphasen und ist der Branchenstandard für Peptid- und Proteintrennungen. Die großen Poren des 300-Å-TP-Silica ermöglichen Polypeptidmolekülen vollständigen Zugang zum Inneren der Silica-Poren.
Artikel-Nr:
(HICH87716)
Lieferant:
Hichrom Limited
Lokale Artikelnummer::
HICH87716
Beschreibung:
Avantor® Alltima HP-Säulen kombinieren eine Reihe chemisch unterschiedlicher Phasen mit hochreiner Silica. Avantor® Alltima HP-Säulen enthalten die höchste Kohlenstoffbeladung für hervorragende Retention und Beladbarkeit.
VE:
1 * 1 ST
Lieferant:
Biotium
Beschreibung:
This MAb recognizes a 21 kDa protein, identified as the p21WAF1 tumor suppressor protein. This MAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma). In ELISA, MAb WA-1 is useful either as a solid phase or for detection of p21 protein.
Artikel-Nr:
(BOSSBS-3583R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3583R-A647
Lokale Artikelnummer::
BOSSBS-3583R-A647
Beschreibung:
TLK1 is a nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly. TLK1 is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9128R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9128R-A647
Lokale Artikelnummer::
BOSSBS-9128R-A647
Beschreibung:
CDCA7 is a nuclear protein without a known function, although its high homology with the transcription factor JPO2 or RAM2 suggests that it is also a transcription factor. CDCA7 is one of many target genes regulated by the c-Myc transcription factor. Overexpression of CDCA7 occurs in a significant proportion of cancers and it may play an important role in tumorigenesis. Normally it is periodically expressed in the cell cycle, peaking at the G1 to S phase transition.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9128R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9128R-CY5.5
Lokale Artikelnummer::
BOSSBS-9128R-CY5.5
Beschreibung:
CDCA7 is a nuclear protein without a known function, although its high homology with the transcription factor JPO2 or RAM2 suggests that it is also a transcription factor. CDCA7 is one of many target genes regulated by the c-Myc transcription factor. Overexpression of CDCA7 occurs in a significant proportion of cancers and it may play an important role in tumorigenesis. Normally it is periodically expressed in the cell cycle, peaking at the G1 to S phase transition.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11788R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11788R-A555
Lokale Artikelnummer::
BOSSBS-11788R-A555
Beschreibung:
The function of PrP is still under debate. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis (By similarity). Isoform 2 may act as a growth suppressor by arresting the cell cycle at the G0/G1 phase. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7895R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7895R-CY3
Lokale Artikelnummer::
BOSSBS-7895R-CY3
Beschreibung:
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.Tissue specificity: Highly expressed in testis and thymus. Expressed also in most cancer cells lines.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3123R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3123R-CY5
Lokale Artikelnummer::
BOSSBS-3123R-CY5
Beschreibung:
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7895R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7895R
Lokale Artikelnummer::
BOSSBS-7895R
Beschreibung:
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.Tissue specificity: Highly expressed in testis and thymus. Expressed also in most cancer cells lines.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3122R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3122R-CY7
Lokale Artikelnummer::
BOSSBS-3122R-CY7
Beschreibung:
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3196R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3196R-CY7
Lokale Artikelnummer::
BOSSBS-3196R-CY7
Beschreibung:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2994R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2994R-CY5
Lokale Artikelnummer::
BOSSBS-2994R-CY5
Beschreibung:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3583R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3583R-HRP
Lokale Artikelnummer::
BOSSBS-3583R-HRP
Beschreibung:
TLK1 is a nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly. TLK1 is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2994R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2994R-HRP
Lokale Artikelnummer::
BOSSBS-2994R-HRP
Beschreibung:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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