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2-(3-(Trifluoromethyl)phenyl)propanoic+acid
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2-(3-(Trifluoromethyl)phenyl)propanoic+acid
Lieferant:
KNAUER
Beschreibung:
Das Knauer Prep LC Premier System ist ein sehr flexibles präparativen Chromatographie System, optimiert für Ihre Synthese- und Reinigungsaufgaben. Das modular aufgebaute System kann leicht an Ihre Applikation und Ansprüche angepasst werden. In der Regel wird die Clarity Prep Software von Dataapex zur Steuerung eingesetzt, ideal für präparativen Arbeit in einem modernen Labor. Um Ihnen einen kurzen Überblick zu geben haben wir 5 fertige Pakete erstellt. Diese Pakete sind der erste Schritt zu Ihrem individuellen Prep LC Premier System.
Lieferant:
Merck
Beschreibung:
Super-Q® Plus System is a high-flow water system designed to provide the 'final polish' to water which has been pretreated by reverse osmosis, distillation or deionization. The systems consistently produce ultrapure water quality which exceeds Type 1 ASTM/CAP/CLSI specifications.
Artikel-Nr:
(FLUO004102-1G)
Lieferant:
FLUOROCHEM
Hersteller-Artikelnummer::
004102-1G
Lokale Artikelnummer::
FLUO004102-1G
Beschreibung:
1,2-Bis(di(pentafluorphenyl)phosphino)ethan
VE:
1 * 1 g
 This is a MarketSource item. Additional charges may apply
Lieferant:
COMBI-BLOCKS
Beschreibung:
Ethyl-8-brom-6-chlorimidazo[1,2-a]pyridin-2-carboxylat
Lieferant:
Alfa Aesar
Beschreibung:
EDTA Trikaliumsalz Dihydrat 99%
Artikel-Nr:
(BOSSBS-9584R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9584R-A350
Lokale Artikelnummer::
BOSSBS-9584R-A350
Beschreibung:
Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-å and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3∫ appears to be activated by both while Stat3å is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by Prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
VE:
1 * 100 µl
Artikel-Nr:
(BNUM0142-50)
Lieferant:
Biotium
Hersteller-Artikelnummer::
BNUM0142-50
Lokale Artikelnummer::
BTIUBNUM0142-50
Beschreibung:
Recognizes a protein of 12 kDa, identified as microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an α heavy chain that contains three subdomains (α1, α2, α3) and a non-covalent associating light chain, known as β-2-Microglobulin. β-2-Microglobulin associates with the α3 subdomain of the α heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The α1 and α2 domains of the α heavy chain form the peptide antigen-binding cleft. Mutations in the β-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
VE:
1 * 50 µl
Artikel-Nr:
(BOSSBS-15307R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15307R-A750
Lokale Artikelnummer::
BOSSBS-15307R-A750
Beschreibung:
C9 is a plasma protein synthesised in the liver and monocytes consisting of a single polypeptide chain. C9 is a part of the membrane attack complex (MAC), an important component of the immune system. The MAC forms upon complement system activation by invading pathogenic bacteria and consists of the four major complement proteins: C5b, C6, C7 and C8. These complement proteins bind to the outer surface of the plasma membrane of the invading cell. C9 binds to the membrane associated C5b-8 protein, which leads to the circular polymerisation of 12-18 C9 molecules. These polymerised C9 molecules form a ring structure in the membrane. Molecules can then diffuse freely through this transmembrane channel, causing cell lysis and destruction of the invading bacterial cell.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15307R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15307R-A350
Lokale Artikelnummer::
BOSSBS-15307R-A350
Beschreibung:
C9 is a plasma protein synthesised in the liver and monocytes consisting of a single polypeptide chain. C9 is a part of the membrane attack complex (MAC), an important component of the immune system. The MAC forms upon complement system activation by invading pathogenic bacteria and consists of the four major complement proteins: C5b, C6, C7 and C8. These complement proteins bind to the outer surface of the plasma membrane of the invading cell. C9 binds to the membrane associated C5b-8 protein, which leads to the circular polymerisation of 12-18 C9 molecules. These polymerised C9 molecules form a ring structure in the membrane. Molecules can then diffuse freely through this transmembrane channel, causing cell lysis and destruction of the invading bacterial cell.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13642R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13642R-FITC
Lokale Artikelnummer::
BOSSBS-13642R-FITC
Beschreibung:
Many growth factors function by binding receptors with intrinsic tyrosine kinase activity (1,2). Signaling by such receptors involves a series of intermediates characterized by SH2 domains that bind tyrosine phosphorylated receptors by a direct interaction between the SH2 domain and the phosphotyrosine-containing receptor sequences (3,4). GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP and a proline-rich N-terminus (5,6). GRB7 maps to the region on mouse chromosome 11 containing the Neu gene (6). This region of mouse chromosome 11 is syntenic to an area of human chromosome 17q that is frequently amplified in breast cancer (6,7). Moreover, GRB7 is amplified and over-expressed in breast cancer and is found in a complex with Neu gp185 (6).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3773R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3773R-CY7
Lokale Artikelnummer::
BOSSBS-3773R-CY7
Beschreibung:
Modulation of the chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. The N-terminal tail of core histones undergoes different posttranslational modifications including acetylation, phosphorylation and methylation. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression. In most species, the histone H2B is primarily acetylated at lysines 5, 12, 15 and 20. Histone H3 is primarily acetylated at lysines 9, 14, 18 and 23. Acetylation at lysine 9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Phosphorylation at Ser10 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11318R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11318R-CY3
Lokale Artikelnummer::
BOSSBS-11318R-CY3
Beschreibung:
The human ataxin-7 gene, also known as spinocerebellar ataxia 7 or SCA7, maps to chromosome 3p13-p12, has a 2,727-bp open reading frame, and encodes a 892 amino acid protein containing a nuclear localization signal and a polyglutamine tract (1,2). SCA7 is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss caused by the expansion of a translated CAG repeat encoding a polyglutamine tract in ataxin-7, which is the SCA7 gene product (3,4). Ataxin-7 is expressed within neurons both affected and unaffected in SCA7 pathology with subcellular localization being variable depending upon the neuronal subtype (5). Polyglutamine expanded in ataxin-7 may carry out its pathogenic effects in the nucleus by altering the matrix-associated nuclear structure and/or by disrupting nucleolar function (6).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3769R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3769R
Lokale Artikelnummer::
BOSSBS-3769R
Beschreibung:
Modulation of the chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. The N-terminal tail of core histones undergoes different posttranslational modifications including acetylation, phosphorylation and methylation. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression. In most species, the histone H2B is primarily acetylated at lysines 5, 12, 15 and 20. Histone H3 is primarily acetylated at lysines 9, 14, 18 and 23. Acetylation at lysine 9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Phosphorylation at Ser10 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8204R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8204R-CY3
Lokale Artikelnummer::
BOSSBS-8204R-CY3
Beschreibung:
NEEP21, also known as Brain neuron cytoplasmic protein 1, NSG1 (neuron-specific proteins family member 1), P21 or D4S234E, is a single pass type II membrane protein belonging to the NSG family. It is highly expressed during neuronal maturation but its expression is downregulated in adult tissues. NEEP21 predominantly localizes to Rab 4-positive early endosomes in the somatodendritic neuronal compartment and is essential for proper receptor sorting and recycling in neurons. It associates with GRIP1 and GluR-2 and mediates the surface expression of GluR-2. When this interaction is interrupted, GluR-2 accumulates in early endosomes and leads to changes in evoked synaptic current properties. In addition, NEEP21 forms a complex with the SNARE protein, Syntaxin 13 (also known as Syntaxin 12), and participates in the recycling of transferrin receptors (TFRs) and NTR2 (neurotensin receptor 2).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12057R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12057R-A750
Lokale Artikelnummer::
BOSSBS-12057R-A750
Beschreibung:
eIF3K (Eukaryotic translation initiation factor 3 subunit K, Muscle-specific gene M9 protein) is a widely expressed translation initiation factor that belongs to the eIF3 subunit K family. Translation initiation factor 3 (eIF3) is a multisubunit complex containing at least 12 subunits. eIF3 binds to the 40S ribosomal subunit, promotes the binding of methionyl-tRNAi and mRNA, and interacts with several other initiation factors to form the 40S initiation complex. eIF3K is the smallest subunit of eIF3 and it interacts with several other subunits of eIF3 and the 40S ribosomal subunit. eIF3K is conserved among high eukaryotes, including mammals, insects, and plants, and it is ubiquitously expressed in human tissues. eIF3K is distributed both in nucleus and cytoplasm and colocalizes with cyclin D3, a regulatory subunit of cyclin-dependent kinase 4 (Cdk4).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12057R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12057R-HRP
Lokale Artikelnummer::
BOSSBS-12057R-HRP
Beschreibung:
eIF3K (Eukaryotic translation initiation factor 3 subunit K, Muscle-specific gene M9 protein) is a widely expressed translation initiation factor that belongs to the eIF3 subunit K family. Translation initiation factor 3 (eIF3) is a multisubunit complex containing at least 12 subunits. eIF3 binds to the 40S ribosomal subunit, promotes the binding of methionyl-tRNAi and mRNA, and interacts with several other initiation factors to form the 40S initiation complex. eIF3K is the smallest subunit of eIF3 and it interacts with several other subunits of eIF3 and the 40S ribosomal subunit. eIF3K is conserved among high eukaryotes, including mammals, insects, and plants, and it is ubiquitously expressed in human tissues. eIF3K is distributed both in nucleus and cytoplasm and colocalizes with cyclin D3, a regulatory subunit of cyclin-dependent kinase 4 (Cdk4).
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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