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Aluminum+oxide-Silicon+oxide
Lieferant:
VWR Chemicals
Beschreibung:
Natriummolybdat(VI) Dihydrat ≥99,0%, GPR RECTAPUR®
Artikel-Nr:
(0541-250G)
Lieferant:
VWR Chemicals
Lokale Artikelnummer::
VWRC0541-250G
Beschreibung:
Natriummolybdat(VI) Dihydrat ≥99,5% ACS
VE:
1 * 250 g
Artikel-Nr:
(BOSSBS-6587R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6587R-A647
Lokale Artikelnummer::
BOSSBS-6587R-A647
Beschreibung:
Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4256R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4256R-CY7
Lokale Artikelnummer::
BOSSBS-4256R-CY7
Beschreibung:
Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide isomerase(PDI) and a number of transcription factors such as p53, NF-kB and AP-1. Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12461R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12461R-A750
Lokale Artikelnummer::
BOSSBS-12461R-A750
Beschreibung:
Aldehyde dehydrogenases (ALDHs) mediate the NADP+-dependent oxidation of aldehydes into acids and play an important role in the detoxification of alcohol-derived acetaldehyde, as well as in lipid peroxidation and in the metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH9A1 (aldehyde dehydrogenase family 9 member A1), also known as E3, ALDH4, ALDH7, ALDH9 or TMABADH, is a 494 amino acid cytoplasmic protein that is highly expressed in adult liver, skeletal muscle, kidney and embryonic brain. ALDH9A1 converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine and catalyses the irreversible oxidation of a broad range of aldehydes to the corresponding acids in a NAD-dependent reaction.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2537R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2537R-A750
Lokale Artikelnummer::
BOSSBS-2537R-A750
Beschreibung:
Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11288R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11288R-CY7
Lokale Artikelnummer::
BOSSBS-11288R-CY7
Beschreibung:
Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5049R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5049R-CY5.5
Lokale Artikelnummer::
BOSSBS-5049R-CY5.5
Beschreibung:
Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3501R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3501R
Lokale Artikelnummer::
BOSSBS-3501R
Beschreibung:
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
VE:
1 * 100 µl
Lieferant:
Merck
Beschreibung:
Natriummolybdat(VI) Dihydrat ≥98,0% (durch Titrationsanalyse auf Trockenmasse) zur Synthese, Sigma-Aldrich®
Artikel-Nr:
(BOSSBS-11297R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11297R-CY3
Lokale Artikelnummer::
BOSSBS-11297R-CY3
Beschreibung:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12461R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12461R-A647
Lokale Artikelnummer::
BOSSBS-12461R-A647
Beschreibung:
Aldehyde dehydrogenases (ALDHs) mediate the NADP+-dependent oxidation of aldehydes into acids and play an important role in the detoxification of alcohol-derived acetaldehyde, as well as in lipid peroxidation and in the metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH9A1 (aldehyde dehydrogenase family 9 member A1), also known as E3, ALDH4, ALDH7, ALDH9 or TMABADH, is a 494 amino acid cytoplasmic protein that is highly expressed in adult liver, skeletal muscle, kidney and embryonic brain. ALDH9A1 converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine and catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in a NAD-dependent reaction.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12461R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12461R-FITC
Lokale Artikelnummer::
BOSSBS-12461R-FITC
Beschreibung:
Aldehyde dehydrogenases (ALDHs) mediate the NADP+-dependent oxidation of aldehydes into acids and play an important role in the detoxification of alcohol-derived acetaldehyde, as well as in lipid peroxidation and in the metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH9A1 (aldehyde dehydrogenase family 9 member A1), also known as E3, ALDH4, ALDH7, ALDH9 or TMABADH, is a 494 amino acid cytoplasmic protein that is highly expressed in adult liver, skeletal muscle, kidney and embryonic brain. ALDH9A1 converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine and catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in a NAD-dependent reaction.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12461R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12461R-HRP
Lokale Artikelnummer::
BOSSBS-12461R-HRP
Beschreibung:
Aldehyde dehydrogenases (ALDHs) mediate the NADP+-dependent oxidation of aldehydes into acids and play an important role in the detoxification of alcohol-derived acetaldehyde, as well as in lipid peroxidation and in the metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH9A1 (aldehyde dehydrogenase family 9 member A1), also known as E3, ALDH4, ALDH7, ALDH9 or TMABADH, is a 494 amino acid cytoplasmic protein that is highly expressed in adult liver, skeletal muscle, kidney and embryonic brain. ALDH9A1 converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine and catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in a NAD-dependent reaction.
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
ß-Nicotinamide adenine dinucleotide phosphate (NADP-Na<sub>2</sub>, oxidized form)
Artikel-Nr:
(BOSSBS-12565R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12565R
Lokale Artikelnummer::
BOSSBS-12565R
Beschreibung:
ALKB protects DNA and RNA against damage from methylating compounds from the environment by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzymes act by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate, and molecular oxygen as the oxidizing agent. Deficiencies in DNA and RNA repair in mammals are associated with cancer, neurological disease and developmental defects. ALKB plays a role in resistance to anti-cancer drugs which attempt to damage tumor DNA. Escherichia coli ALKB protein belongs to the superfamily of 2-oxoglutarate- and iron(II)-dependent oxygenases.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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