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Arachidons\u00E4ure
Artikel-Nr:
(BOSSBS-5060R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5060R-A680
Lokale Artikelnummer::
BOSSBS-5060R-A680
Beschreibung:
FADS1 is a component of a lipid metabolic pathway that catalyses biosynthesis of highly unsaturated fatty acids from precursor essential polyunsaturated fatty acids, linoleic acid and alphanlinolenic acid. It catalyses the desaturation of dihomo gamma linoleic acid and eicosatetraenoic acid to generate arachidonic acid and eicosapentaenoic acid respectively.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6505R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6505R-A647
Lokale Artikelnummer::
BOSSBS-6505R-A647
Beschreibung:
Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes and synthesis of signaling molecules, as well as inducing structural and metabolic changes in the cell. The Lox enzymes in mammals include 12-LO and 15-LO, which are classified with respect to their positional specificity of the deoxygenation of their most common substrate, arachidonic acid. The metabolism of arachidonic acid leads to the generation of biologically active metabolites that have been implicated in cell growth and proliferation, as well as survival and apoptosis. 15-Lipoxygenase (15-LO) acts in physiological membrane remodeling and the pathogenesis of atherosclerosis, inflammation, and carcinogenesis. It is highly regulated and expressed in a tissue- and cell-type-specific fashion. IL-4 and IL-13 play important roles in transactivating the 15-LO gene. Overexpression of 15-LO type 1 in prostate cancer contributes to the cancer progression by regulating IGF-1R expression and activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6505R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6505R-FITC
Lokale Artikelnummer::
BOSSBS-6505R-FITC
Beschreibung:
Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes and synthesis of signaling molecules, as well as inducing structural and metabolic changes in the cell. The Lox enzymes in mammals include 12-LO and 15-LO, which are classified with respect to their positional specificity of the deoxygenation of their most common substrate, arachidonic acid. The metabolism of arachidonic acid leads to the generation of biologically active metabolites that have been implicated in cell growth and proliferation, as well as survival and apoptosis. 15-Lipoxygenase (15-LO) acts in physiological membrane remodeling and the pathogenesis of atherosclerosis, inflammation, and carcinogenesis. It is highly regulated and expressed in a tissue- and cell-type-specific fashion. IL-4 and IL-13 play important roles in transactivating the 15-LO gene. Overexpression of 15-LO type 1 in prostate cancer contributes to the cancer progression by regulating IGF-1R expression and activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5060R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5060R-A647
Lokale Artikelnummer::
BOSSBS-5060R-A647
Beschreibung:
FADS1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids from precursor essential polyunsaturated fatty acids, linoleic acid and alphanlinolenic acid. It catalyzes the desaturation of dihomo gamma linoleic acid and eicosatetraenoic acid to generate arachidonic acid and eicosapentaenoic acid respectively.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6505R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6505R-CY7
Lokale Artikelnummer::
BOSSBS-6505R-CY7
Beschreibung:
Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes and synthesis of signaling molecules, as well as inducing structural and metabolic changes in the cell. The Lox enzymes in mammals include 12-LO and 15-LO, which are classified with respect to their positional specificity of the deoxygenation of their most common substrate, arachidonic acid. The metabolism of arachidonic acid leads to the generation of biologically active metabolites that have been implicated in cell growth and proliferation, as well as survival and apoptosis. 15-Lipoxygenase (15-LO) acts in physiological membrane remodeling and the pathogenesis of atherosclerosis, inflammation, and carcinogenesis. It is highly regulated and expressed in a tissue- and cell-type-specific fashion. IL-4 and IL-13 play important roles in transactivating the 15-LO gene. Overexpression of 15-LO type 1 in prostate cancer contributes to the cancer progression by regulating IGF-1R expression and activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6709R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6709R-CY3
Lokale Artikelnummer::
BOSSBS-6709R-CY3
Beschreibung:
Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods. Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10411R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10411R-A680
Lokale Artikelnummer::
BOSSBS-10411R-A680
Beschreibung:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumour angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12999R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12999R-A680
Lokale Artikelnummer::
BOSSBS-12999R-A680
Beschreibung:
Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12999R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12999R-A647
Lokale Artikelnummer::
BOSSBS-12999R-A647
Beschreibung:
Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12999R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12999R-A488
Lokale Artikelnummer::
BOSSBS-12999R-A488
Beschreibung:
Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0420R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0420R-A555
Lokale Artikelnummer::
BOSSBS-0420R-A555
Beschreibung:
Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0420R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0420R-A750
Lokale Artikelnummer::
BOSSBS-0420R-A750
Beschreibung:
Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3874R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3874R-HRP
Lokale Artikelnummer::
BOSSBS-3874R-HRP
Beschreibung:
12 Lipoxygenase is a non heme iron containing dioxygenase which stereospecifically incorporates molecular oxygen into cis,cis-1,4-pentadiene containing polyunsaturated fatty acids. Murine leukocyte 12 Lipoxygenase oxidizes arachidonic acid to 12(S)-HpETE and 15(S)-HpETE in a ratio of 3:1. Murine leukocyte 12 Lipoxygenase is a 75 kDa protein which is 58% homologous to murine platelet 12 Lipoxygenase, and 70% homologous to porcine leukocyte 12 Lipoxygenase.
VE:
1 * 100 µl
Lieferant:
Cayman Chemical
Beschreibung:
9(R)-HODE is one of several monohydroxylated products of linoleic acid. All known mammalian lipoxygenases appear to catalyze the oxygenation of arachidonic and linoleic acid to give products having strictly the (S) configuration at the site of oxygen insertion. However, both human umbilical vein endothelial cells and bovine aorta endothelial cells have been shown to produce 9(R)-HODE when incubated with linoleic acid.
The physiological function of 9(R)-HODE and the enzyme that catalyzes its formation have not been determined.
Artikel-Nr:
(BOSSBS-3251R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3251R-A488
Lokale Artikelnummer::
BOSSBS-3251R-A488
Beschreibung:
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3251R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3251R-CY5.5
Lokale Artikelnummer::
BOSSBS-3251R-CY5.5
Beschreibung:
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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