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Boron+trifluoridedimethanol+complex
Artikel-Nr:
(BOSSBS-11427R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11427R-A350
Lokale Artikelnummer::
BOSSBS-11427R-A350
Beschreibung:
In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signals between transcriptional activators and RNA polymerase (1). These complexes include the SMCC (SRB and MED protein cofactor complex), which consists of various subunits that share homology with several components of the yeast transcriptional mediator complexes, and including the human proteins Srb7, Med6 (also designated DRIP33) and Med7 (also designated DRIP34) (2,3). SMCC associates with the RNAPII (RNA polymerase II) holoenzyme through Srb7 and, in turn, enhances gene-specific activation or repression induced by DNA-binding transcription factors (4). Med6 and Med7, as well as other components of SMCC, associate with coactivator proteins from the TRAP (thyroid hormone receptor-activating protein) complex and DRIP (for vitamin D receptor interacting protein) complex to facilitate steroid receptor dependent transcriptional activation (4,5). Additionally, SMCC associates with PC4 (positive cofactor 4) to repress basal transcription independent of RNAPII activity (6).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11427R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11427R-HRP
Lokale Artikelnummer::
BOSSBS-11427R-HRP
Beschreibung:
In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signals between transcriptional activators and RNA polymerase (1). These complexes include the SMCC (SRB and MED protein cofactor complex), which consists of various subunits that share homology with several components of the yeast transcriptional mediator complexes, and including the human proteins Srb7, Med6 (also designated DRIP33) and Med7 (also designated DRIP34) (2,3). SMCC associates with the RNAPII (RNA polymerase II) holoenzyme through Srb7 and, in turn, enhances gene-specific activation or repression induced by DNA-binding transcription factors (4). Med6 and Med7, as well as other components of SMCC, associate with coactivator proteins from the TRAP (thyroid hormone receptor-activating protein) complex and DRIP (for vitamin D receptor interacting protein) complex to facilitate steroid receptor dependent transcriptional activation (4,5). Additionally, SMCC associates with PC4 (positive cofactor 4) to repress basal transcription independent of RNAPII activity (6).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8248R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8248R-A647
Lokale Artikelnummer::
BOSSBS-8248R-A647
Beschreibung:
May forms part of a complex of membrane proteins attached to acetylcholinesterase (AChE).Tissue specificity:Ubiquitous. Widely expressed in brain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12121R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12121R-A488
Lokale Artikelnummer::
BOSSBS-12121R-A488
Beschreibung:
Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8248R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8248R-A555
Lokale Artikelnummer::
BOSSBS-8248R-A555
Beschreibung:
May forms part of a complex of membrane proteins attached to acetylcholinesterase (AChE).Tissue specificity:Ubiquitous. Widely expressed in brain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8248R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8248R
Lokale Artikelnummer::
BOSSBS-8248R
Beschreibung:
May forms part of a complex of membrane proteins attached to acetylcholinesterase (AChE).Tissue specificity:Ubiquitous. Widely expressed in brain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11860R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11860R-A350
Lokale Artikelnummer::
BOSSBS-11860R-A350
Beschreibung:
Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12121R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12121R
Lokale Artikelnummer::
BOSSBS-12121R
Beschreibung:
Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13032R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13032R-HRP
Lokale Artikelnummer::
BOSSBS-13032R-HRP
Beschreibung:
In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signals between transcriptional activators and RNA polymerase (1). These complexes include CRSP (for cofactor required for Sp1 activation), which is required, in conjunction with TAFIIs, for transcriptional activation by Sp1 (2). CRSP is ubiquitously expressed in various tissues and functions as a multimeric complex that consists of nine distinct subunits (3). Several members of the CRSP family share sequence similarity with multiple components of the yeast transcriptional mediator proteins, including CRSP150, which is related to yeast Rgr1, and CRSP70, which is similar to the elongation factor TFIIS (4). CRSP77 and CRSP150 are also related to proteins within the putative murine mediator complex, while CRSP130 and CRSP34 are largely unrelated to either murine or yeast proteins (2,5). CRSP subunits also associate with larger multimeric coactivaor complexes, including ARC/DRI, which binds directly to SREBP and nuclear hormone receptors to facilitate transcription, and with NAT, a polymerase II-interacting complex that represses activated transcription (6,7).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6456R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6456R-CY5
Lokale Artikelnummer::
BOSSBS-6456R-CY5
Beschreibung:
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6456R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6456R-CY5.5
Lokale Artikelnummer::
BOSSBS-6456R-CY5.5
Beschreibung:
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8248R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8248R-CY5
Lokale Artikelnummer::
BOSSBS-8248R-CY5
Beschreibung:
May forms part of a complex of membrane proteins attached to acetylcholinesterase (AChE).Tissue specificity:Ubiquitous. Widely expressed in brain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8248R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8248R-CY7
Lokale Artikelnummer::
BOSSBS-8248R-CY7
Beschreibung:
May forms part of a complex of membrane proteins attached to acetylcholinesterase (AChE).Tissue specificity:Ubiquitous. Widely expressed in brain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11860R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11860R-A750
Lokale Artikelnummer::
BOSSBS-11860R-A750
Beschreibung:
Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation Signalling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11860R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11860R-A680
Lokale Artikelnummer::
BOSSBS-11860R-A680
Beschreibung:
Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation Signalling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5517R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5517R
Lokale Artikelnummer::
BOSSBS-5517R
Beschreibung:
NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NFKB interaction with other transcription factors, such as STAT, AP1 (JUN), and NFAT.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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