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VARLP032522BAKR00001
Artikel-Nr:
(HONC72187-45L-RC)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
72187-45L-RC
Lokale Artikelnummer::
HONC72187-45L-RC
Beschreibung:
Tetrahydrofuran, Puriss. p.a. ACS, Reag. Ph. Eur., Riedel-de Haën™
VE:
1 * 45 L
Lieferant:
Bernd Kraft
Beschreibung:
Amidoschwefelsäure 100 g/l in wässriger Lösung analytisches Reagens
Artikel-Nr:
(PRSI79-354)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-354
Lokale Artikelnummer::
PRSI79-354
Beschreibung:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.
VE:
1 * 100 µG
Artikel-Nr:
(UPCHA-703)
Lieferant:
UPCHURCH SCIENTIFIC
Hersteller-Artikelnummer::
A-703
Lokale Artikelnummer::
UPCHA-703
Beschreibung:
Außerordentlich einheitliche Porosität, die eine längere Filtration und konsistentes Hubvolumen von Fritte zu Fritte gewährleistet. Diese Fritten sind biokompatibel und inert gegenüber den meisten Lösungsmitteln, sodass sie sich gut für bioanalytische Anwendungen eignen. Die Scheibenringe aus PCTFE sind ein wenig dicker als die Frittenscheibe und bieten eine verbesserte Abdichtung und ausgezeichnete Chemikalienbeständigkeit.
VE:
1 * 1 ST
Artikel-Nr:
(PRSIXP-5169)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
XP-5169
Lokale Artikelnummer::
PRSIXP-5169
Beschreibung:
IL-15 (14-15 kD) is a member of the four alpha-helical bundle family of cytokines. It is very similar to IL-2, except that IL-15 has an IL-15 alpha receptor subunit. IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules. This implies that IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI29-556)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
29-556
Lokale Artikelnummer::
PRSI29-556
Beschreibung:
ASS catalyzes the penultimate step of the arginine biosynthetic pathway.The protein encoded by this gene catalyzes the penultimate step of the arginine biosynthetic pathway. There are approximately 10 to 14 copies of this gene including the pseudogenes scattered across the human genome, among which the one located on chromosome 9 appears to be the only functional gene for argininosuccinate synthetase. Mutations in the chromosome 9 copy of ASS cause citrullinemia. Two transcript variants encoding the same protein have been found for this gene.
VE:
1 * 100 µG
Artikel-Nr:
(612-5485)
Lieferant:
B. Braun
Hersteller-Artikelnummer::
8713050
Lokale Artikelnummer::
BRAU8713050
Beschreibung:
The volumetric infusion pump Infusomat® Space is one of the basic building blocks of the Space system, designed for acute care adult and pediatric facilities.
VE:
1 * 1 ST
Lieferant:
COMBI-BLOCKS
Beschreibung:
4-(tert-Butylcarbamoyl)phenylboronsäure
Lieferant:
COMBI-BLOCKS
Beschreibung:
1-Boc-5-methyl-2-indolboronsäure
Lieferant:
Bernd Kraft
Beschreibung:
Amidoschwefelsäure 10% in wässriger Lösung, reinst
Artikel-Nr:
(LOVI418453)
Lieferant:
Lovibond Tintometer
Hersteller-Artikelnummer::
418453
Lokale Artikelnummer::
LOVI418453
Beschreibung:
Diese Kits wurden speziell für die Untersuchung von Wasser (Kessel-, Kühl- und Brauchwasser) entwickelt.
VE:
1 * 1 ST
Artikel-Nr:
(BOSSBS-4985R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4985R-A750
Lokale Artikelnummer::
BOSSBS-4985R-A750
Beschreibung:
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4985R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4985R-HRP
Lokale Artikelnummer::
BOSSBS-4985R-HRP
Beschreibung:
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5251R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5251R-CY5.5
Lokale Artikelnummer::
BOSSBS-5251R-CY5.5
Beschreibung:
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A. Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Also phosphorylates NEK6. Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination. Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation. Also promotes repair of DNA cross-links through phosphorylation of FANCE. Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may enhance chromatin assembly both in the presence or absence of DNA damage. May also play a role in replication fork maintenance through regulation of PCNA.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4985R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4985R-A680
Lokale Artikelnummer::
BOSSBS-4985R-A680
Beschreibung:
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R.
VE:
1 * 100 µl
Artikel-Nr:
(FLUO013947-1G)
Lieferant:
FLUOROCHEM
Hersteller-Artikelnummer::
013947-1G
Lokale Artikelnummer::
FLUO013947-1G
Beschreibung:
2-Brom-5-pyridinboronsäure
VE:
1 * 1 g
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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