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2-Amino-5-ethoxy-6-methylpyridine
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2-Amino-5-ethoxy-6-methylpyridine
Artikel-Nr:
(COBBHC-6213-1G)
Lieferant:
COMBI-BLOCKS
Hersteller-Artikelnummer::
HC-6213-1G
Lokale Artikelnummer::
COBBHC-6213-1G
Beschreibung:
Ethyl-8-brom-4-hydroxychinolin-3-carboxylat
VE:
1 * 1 g
 This is a MarketSource item. Additional charges may apply
Lieferant:
COMBI-BLOCKS
Beschreibung:
Ethyl-5-(2,3-dichlorphenyl)-4-oxazolcarboxylat
Lieferant:
Sigma-Aldrich
Beschreibung:
2-(Diisopropylamino)ethyl methacrylate, Stabilized with 80-100 ppm MEHQ
Lieferant:
COMBI-BLOCKS
Beschreibung:
N-Ethyl-2-nitro-4-(trifluormethyl)anilin
Artikel-Nr:
(MENAST1157.100)
Lieferant:
MENAI
Hersteller-Artikelnummer::
ST1157.100
Lokale Artikelnummer::
MENAST1157.100
Beschreibung:
Ethyl-2-amino-4-methylthiazol-5-carboxylat
VE:
1 * 100 g
Lieferant:
COMBI-BLOCKS
Beschreibung:
4-Brom-N-ethyl-2-fluoranilin Hydrochlorid
Lieferant:
FLUOROCHEM
Beschreibung:
Ethyl-4-hydroxy-6-(trifluormethoxy)chinolin-3-carboxylat
Lieferant:
COMBI-BLOCKS
Beschreibung:
Ethyl-4,6,8-trichlorchinolin-3-carboxylat
Lieferant:
COMBI-BLOCKS
Beschreibung:
Ethyl-2-amino-4-chlorbenzoat
Artikel-Nr:
(PRSI31-121)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
31-121
Lokale Artikelnummer::
PRSI31-121
Beschreibung:
PACSIN1 may play a role in vesicle formation and transport.
VE:
1 * 100 µG
Artikel-Nr:
(BOSSBS-3406R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3406R-A647
Lokale Artikelnummer::
BOSSBS-3406R-A647
Beschreibung:
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromosome proteins are conserved in eukaryotes and can lead to mitotic chromosome segregation defects, suggesting a critical function of SMC family proteins in mitotic chromosome dynamics. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. Specifically this SMC1/SMC3 complex is responsible for sister chromatid cohesion during metaphase. A number of cellular factors interact with hSMC1/hSMC3 during cell cycle. The major population of hSMC1/hSMC3 is in a compex with hRAD21 forming the human cohesion complex. Human cohesion complex associates with chromosomes which peaks at S phase and dissociates from chromosomes during G2/M transition. In addition, a subpopulation of hSMC1/hSMC3 associates tightly with nuclear matrix and centrosomes during interphase. A subset of hSMC1/hSMC3 is localized to spindle poles, spindles and kinetochores during mitosis when cohesin is in the cytoplasm. hSMC1/hSMC3 is required for spindle aster formation in vitro and reacts with nuclear mitotic apparatus protein in vivo.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3406R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3406R-A555
Lokale Artikelnummer::
BOSSBS-3406R-A555
Beschreibung:
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromosome proteins are conserved in eukaryotes and can lead to mitotic chromosome segregation defects, suggesting a critical function of SMC family proteins in mitotic chromosome dynamics. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. Specifically this SMC1/SMC3 complex is responsible for sister chromatid cohesion during metaphase. A number of cellular factors interact with hSMC1/hSMC3 during cell cycle. The major population of hSMC1/hSMC3 is in a compex with hRAD21 forming the human cohesion complex. Human cohesion complex associates with chromosomes which peaks at S phase and dissociates from chromosomes during G2/M transition. In addition, a subpopulation of hSMC1/hSMC3 associates tightly with nuclear matrix and centrosomes during interphase. A subset of hSMC1/hSMC3 is localized to spindle poles, spindles and kinetochores during mitosis when cohesin is in the cytoplasm. hSMC1/hSMC3 is required for spindle aster formation in vitro and reacts with nuclear mitotic apparatus protein in vivo.
VE:
1 * 100 µl
Lieferant:
BIONET RESEARCH
Beschreibung:
Ethyl-5-amino-2-benzo[b]thiophencarboxylat
Artikel-Nr:
(BOSSBS-0485R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0485R-FITC
Lokale Artikelnummer::
BOSSBS-0485R-FITC
Beschreibung:
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6213R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6213R-A350
Lokale Artikelnummer::
BOSSBS-6213R-A350
Beschreibung:
This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (HIF-1 alpha and HIF-1 beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha protein is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIF1s regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions.
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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