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IGEPAL\\\\u00AE+CA-630
Artikel-Nr:
(BOSSBS-10382R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10382R-CY3
Lokale Artikelnummer::
BOSSBS-10382R-CY3
Beschreibung:
Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0749R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0749R-CY7
Lokale Artikelnummer::
BOSSBS-0749R-CY7
Beschreibung:
Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-1 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-1, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-1 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0749R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0749R-HRP
Lokale Artikelnummer::
BOSSBS-0749R-HRP
Beschreibung:
Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-1 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-1, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-1 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
VE:
1 * 100 µl
Artikel-Nr:
(ABNOKA6887.1KIT)
Lieferant:
Abnova
Hersteller-Artikelnummer::
KA6887.1KIT
Lokale Artikelnummer::
ABNOKA6887.1KIT
Beschreibung:
The CA 15-3 ELISA Kit is an enzyme immunoassay for the quantitative in vitro diagnostic measurement of CA 15-3 in serum and plasma.
VE:
1 * 1 KIT
Artikel-Nr:
(BOSSBS-11542R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11542R-HRP
Lokale Artikelnummer::
BOSSBS-11542R-HRP
Beschreibung:
Calcineurin is a Ca(2+) dependent protein phosphatase that is involed in several neuornal functions. Proteins belonging to the RCAN (Regulator of calcineurin) family modulate the activity of Calcineurin through a valine-rich region within their carboxyl tail. RCANs compete with NFATs (Nuclear factor of activated T-cells) for binding to the same docking site in calcineurin, which results in either inhibition or activation of calcineurin activity. Calcipressin-2, also known as RCAN2 and DSCR1L1 (Down syndrome candidate region 1-like 1), is a 197 amino acid protein that is highly expressed in both the cytoplasm and nucleus of neurons and is the only RCAN family member that is found in glial cells. Calcipressin-3, also known as RCAN3 and DSCR1L2 (Down syndrome candidate region 1-like protein 2), is a 241 amino acid protein that potentially is involved in central nervous system development. Calcipressin-3 interacts with cardiac troponin I, suggesting that it may play a role in cardiac contraction events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10417R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10417R-HRP
Lokale Artikelnummer::
BOSSBS-10417R-HRP
Beschreibung:
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11066R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11066R-A647
Lokale Artikelnummer::
BOSSBS-11066R-A647
Beschreibung:
The downstream of kinase family (Dok-1-7) are members of a class of “docking†proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4, Dok-5 and Dok-6 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to insulin and insulin-like growth factor-1. Dok-6 is highly expressed in the developing central nervous system. It associates with Ret to transduce Ret-mediated processes such as axonal projection.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11066R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11066R-CY3
Lokale Artikelnummer::
BOSSBS-11066R-CY3
Beschreibung:
The downstream of kinase family (Dok-1-7) are members of a class of “docking†proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4, Dok-5 and Dok-6 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to insulin and insulin-like growth factor-1. Dok-6 is highly expressed in the developing central nervous system. It associates with Ret to transduce Ret-mediated processes such as axonal projection.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10397R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10397R-A647
Lokale Artikelnummer::
BOSSBS-10397R-A647
Beschreibung:
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11359R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11359R-A750
Lokale Artikelnummer::
BOSSBS-11359R-A750
Beschreibung:
Rab 3, a neural/neuroendocrine-specific member of the Rab family, is involved in Ca²⁺ regulated exocytosis and functions in an inhibitory capacity, controlling the recruitment and pooling of secretory vesicles at the plasma membrane. The Rim (Rab 3 interacting molecule) family of proteins (Rim1, Rim2, Rim3 and Rim4) are multidomain adaptors that regulate Rab 3 activity and sub-sequent neurotransmitter release. Rim3, also known as RIMS3 (regulating synaptic membrane exocytosis 3) or NIM3, is a 308 amino acid member of the Rim family. localised to the synapse and to cell junctions, Rim3 contains one C2 domain and is thought to play an important role in the regulation of synaptic membrane exocytosis. Rim3, a protein that may be phosphorylated upon DNA damage, is expressed throughout the body with highest levels present in brain tissue.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11066R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11066R-A750
Lokale Artikelnummer::
BOSSBS-11066R-A750
Beschreibung:
The downstream of kinase family (Dok-1-7) are members of a class of docking proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4, Dok-5 and Dok-6 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to insulin and insulin-like growth factor-1. Dok-6 is highly expressed in the developing central nervous system. It associates with Ret to transduce Ret-mediated processes such as axonal projection.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11066R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11066R-CY5
Lokale Artikelnummer::
BOSSBS-11066R-CY5
Beschreibung:
The downstream of kinase family (Dok-1-7) are members of a class of “docking†proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4, Dok-5 and Dok-6 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to insulin and insulin-like growth factor-1. Dok-6 is highly expressed in the developing central nervous system. It associates with Ret to transduce Ret-mediated processes such as axonal projection.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2748R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2748R-A750
Lokale Artikelnummer::
BOSSBS-2748R-A750
Beschreibung:
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2748R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2748R-A555
Lokale Artikelnummer::
BOSSBS-2748R-A555
Beschreibung:
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3146R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3146R-CY5.5
Lokale Artikelnummer::
BOSSBS-3146R-CY5.5
Beschreibung:
Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9634R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9634R-A680
Lokale Artikelnummer::
BOSSBS-9634R-A680
Beschreibung:
The Isocitrate dehydrogenase cytoplasmic enzyme is a homodimer of 416 residues that belongs to the isocitrate and isopropylmalate dehydrogenases family. IDHC catalyses the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming ketoglutarate and CO₂ in a two step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of ketoglutarate. During this process, either NADH or NADPH is produced along with CO₂. Ca²⁺ can bind to IDHC as a complex with isocitrate, acting as a competitive inhibitor of Mg²⁺. The IDHC enzyme is inactivated by phosphorylation at Ser-113 and contains a clasp-like domain wherein both polypeptide chains in the dimer interlock. IDHC is expressed in a wide range of species and also in organisms that lack a complete citric acid cycle.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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