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5-(4-Fluorophenyl)valeric+acid
Artikel-Nr:
(BOSSBS-13029R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13029R-A488
Lokale Artikelnummer::
BOSSBS-13029R-A488
Beschreibung:
Dipeptidyl peptidases (DPPs) mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. DPPs have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells. DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP10, DPPX and CD26. DPP3 (dipeptidyl-peptidase 3), also known as DPPIII, is a zinc-exopeptidase that belongs to the peptidase M49 family. DPP3 localizes to the cytoplasm and is involved in intracellular protein catabolism. More specifically, DPP3 is an important enzyme involved in the degradation of enkephalins. An increase in the activity of DPP3 is implicated in ovarian and endometrial cancers.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13029R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13029R-FITC
Lokale Artikelnummer::
BOSSBS-13029R-FITC
Beschreibung:
Dipeptidyl peptidases (DPPs) mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. DPPs have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells. DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP10, DPPX and CD26. DPP3 (dipeptidyl-peptidase 3), also known as DPPIII, is a zinc-exopeptidase that belongs to the peptidase M49 family. DPP3 localizes to the cytoplasm and is involved in intracellular protein catabolism. More specifically, DPP3 is an important enzyme involved in the degradation of enkephalins. An increase in the activity of DPP3 is implicated in ovarian and endometrial cancers.
VE:
1 * 100 µl
Lieferant:
Bernd Kraft
Beschreibung:
Kaliumchlorid 150 g/l in wässriger Lösung, reinst
Lieferant:
APPLICHEM
Beschreibung:
Kaliumchlorid 99,0-100,5 argentometric_dried USP, Ph. Eur., BP, pharma grade
Lieferant:
Bernd Kraft
Beschreibung:
Kaliumchlorid 0.2 mol/l (0.2 N) in wässriger Lösung
Lieferant:
Thermo Scientific
Beschreibung:
Kaliumsulfat 99+% für die Biochemie
Artikel-Nr:
(WTWA109706)
Lieferant:
WTW
Hersteller-Artikelnummer::
109706
Lokale Artikelnummer::
WTWA109706
Beschreibung:
Kaliumchlorid 3 mol/l (3 N) in wässriger Lösung
VE:
1 * 50 mL
Lieferant:
Bernd Kraft
Beschreibung:
Kaliumpermanganat 0.2 mol/l (1 N) in wässriger Lösung
Artikel-Nr:
(BOSSBS-9045R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9045R-A680
Lokale Artikelnummer::
BOSSBS-9045R-A680
Beschreibung:
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarisation, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2015R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2015R-A488
Lokale Artikelnummer::
BOSSBS-2015R-A488
Beschreibung:
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11733R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11733R-CY3
Lokale Artikelnummer::
BOSSBS-11733R-CY3
Beschreibung:
Myotubularin and the myotubularin-related proteins (MTMR1-9) belong to a highly conserved family of eukaryotic phosphatases. They are protein tyrosine phosphatases that utilize inositol phospholipids, rather than phosphoproteins, as substrates. MTMR family members hydrolyze both Phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2. MTMR2 interacts with MTMR5, an inactive family member that increases the enzymatic activity of MTMR2 and dictates its subcellular localization. Mutations in MTMR2 cause autosomal recessive Charcot-Marie-Tooth type 4B1 (CMT4B1), which is characterized by reduced nerve conduction velocities, focally folded myelin sheaths and demyelination. MTMR3 and MTMR4 can either interact with each other or self associate. MTMR6 regulates the activity of the calcium-activated potassium channel 3.1. MTMR9 regulates the activity of MTMR7 and MTMR8.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7689R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7689R-A750
Lokale Artikelnummer::
BOSSBS-7689R-A750
Beschreibung:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca2+/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11733R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11733R-A680
Lokale Artikelnummer::
BOSSBS-11733R-A680
Beschreibung:
Myotubularin and the myotubularin-related proteins (MTMR1-9) belong to a highly conserved family of eukaryotic phosphatases. They are protein tyrosine phosphatases that utilize inositol phospholipids, rather than phosphoproteins, as substrates. MTMR family members hydrolyse both Phosphatidylinositol 3-phosphate (PtdIns3P) and PtdInsP2. MTMR2 interacts with MTMR5, an inactive family member that increases the enzymatic activity of MTMR2 and dictates its subcellular localisation. Mutations in MTMR2 cause autosomal recessive Charcot-Marie-Tooth type 4B1 (CMT4B1), which is characterised by reduced nerve conduction velocities, focally folded myelin sheaths and demyelination. MTMR3 and MTMR4 can either interact with each other or self associate. MTMR6 regulates the activity of the calcium-activated potassium channel 3.1. MTMR9 regulates the activity of MTMR7 and MTMR8.
VE:
1 * 100 µl
Artikel-Nr:
(APPC182651.1611)
Lieferant:
APPLICHEM
Hersteller-Artikelnummer::
182651.1611
Lokale Artikelnummer::
APPC182651.1611
Beschreibung:
Kaliumpermanganat 0.1 mol/l (0.5N) volumetrische Lösung
VE:
1 * 1.000 mL
Lieferant:
COMBI-BLOCKS
Beschreibung:
Kalium(2-pyridyl)trifluoroborat
Artikel-Nr:
(BOSSBS-1945R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1945R-CY7
Lokale Artikelnummer::
BOSSBS-1945R-CY7
Beschreibung:
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway. Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner. Isoform 1, isoform 2, isoform 3 and isoform 4 stimulate the activity of SLC12A1, SLC12A2 and SLC12A3 and inhibit the activity of SLC12A4, SLC12A5, SLC12A6 and SLC12A7. According to PubMed:19470686, isoform 1 inhibits the activity of SLC12A3.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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