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Artikel-Nr: (PRSI92-432)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 92-432

Lokale Artikelnummer:: PRSI92-432

Beschreibung: GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signalling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1.

VE: 1 * 50 µG

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Artikel-Nr: (PRSI79-719)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 79-719

Lokale Artikelnummer:: PRSI79-719

Beschreibung: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI33-629)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 33-629

Lokale Artikelnummer:: PRSI33-629

Beschreibung: CD28 is the critical T-cell co-stimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its co-stimulation role, CD28 functions in preventing T-cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI96-482)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 96-482

Lokale Artikelnummer:: PRSI96-482

Beschreibung: Protein jagged-1 (JAG1) is also known as Jagged1, hJ1, JAGL1 and CD339, which is a single-pass type I membrane protein containing one DSL domain and 15 EGF-like domains. JAG1 is widely expressed in adult and fetal tissues,the expression of JAG1 is up-regulated in cervical squamous cell carcinoma and also expressed in bone marrow cell line HS-27a.JAG1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. JAG1 is involved in early and late stages of mammalian cardiovascular development. JAG1 inhibits myoblast differentiation by similarity and enhances fibroblast growth factor-induced angiogenesis (in vitro).

VE: 1 * 50 µG

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Artikel-Nr: (PRSI34-036)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 34-036

Lokale Artikelnummer:: PRSI34-036

Beschreibung: Adipophilin belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material and maybe involved in development and maintenance of adipose tissue. It is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI2299)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 2299

Lokale Artikelnummer:: PRSI2299

Beschreibung: DcR1 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI33-826)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 33-826

Lokale Artikelnummer:: PRSI33-826

Beschreibung: A disulphide-linked heterodimer, consisting of mb-1 (or CD79a) and B29 (or CD79b) polypeptides, is non-covalently associated with membrane-bound immunoglobulins on B cells. This complex of mb-1 and B29 polypeptides and immunoglobulin constitute the B cell Ag receptor. CD79a first appears at pre B cell stage, early in maturation, and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. It is not present in myeloid or T cell lines. Anti-CD79a is generally used to complement anti-CD20 especially for mature B-cell lymphomas after treatment with Rituximab (anti-CD20). This antibody will stain many of the same lymphomas as anti-CD20, but also is more likely to stain B-lymphoblastic lymphoma/leukemia than is anti-CD20. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI28-342)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 28-342

Lokale Artikelnummer:: PRSI28-342

Beschreibung: NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has high expression in myeloid leukemia cell lines.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI91-569)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 91-569

Lokale Artikelnummer:: PRSI91-569

Beschreibung: alpha-N-Acetylneuraminide alpha-2,8-Sialyltransferase (ST8SIA1) belongs to the glycosyltransferase 29 family. ST8SIA1 is a sialytransferase that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce GD3 and GT3. ST8SIA1 is highly expressed in melanoma cell lines, adult and fetal brain, low expressed in adult and fetal lung. ST8SIA1 may act as a type II transmembrane protein with a short N-termianl cytoplasmic domain and a single-pass transmembrane domain folowed by an enzymatic domain in the lument of the Golgi apparatus.

VE: 1 * 50 µG

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Artikel-Nr: (PRSI38-222)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 38-222

Lokale Artikelnummer:: PRSI38-222

Beschreibung: Macrophage Inflammatory Protein 1 alpha and MIP1 beta, two closely related but distinct proteins, were originally co-purified from medium conditioned by a LPS-stimulated murine macrophage cell line. Mature mouse MIP1 alpha shares approximately 77% and 70% amino acid identity with human MIP1 alpha and mouse MIP1 beta, respectively. MIP1 proteins are expressed primarily in T cells, B cells, and monocytes after antigen or mitogen stimulation.

VE: 1 * 50 µG

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Artikel-Nr: (PRSI76-887)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 76-887

Lokale Artikelnummer:: PRSI76-887

Beschreibung: The H4A3 monoclonal antibody specifically reacts with human CD107a, a heavily glycosylated type I membrane glycoprotein. CD107a is also known as Lysosomal-associated membrane protein 1 (LAMP-1) and is widely expressed intracellular antigen. It can be found on the surface of PHA-activated lymphocytes, activated platelets, cytotoxic T cells, NK cells, macrophages, epithelial cells, endothelial cells, and some tumor lines. CD107a is a ligand for E-selectin and galaptin and is reported to be involved in cell adhesion and tumor metastasis.

VE: 1 * 0,1 mg

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Artikel-Nr: (PRSI92-017)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 92-017

Lokale Artikelnummer:: PRSI92-017

Beschreibung: Zinc Finger Protein 75A (ZNF75A) is a member of krueppel C2H2-type zinc-finger protein family. The human ZNF75 gene is located on Xq26, which has only limited homology (less than 65%) to other ZF genes in the databases. One of these, ZNF75B is a pseudogene mapped to chromosome 12q13. The other two, ZNF75A and ZNF75C, maintain an ORF in the sequenced region, and at least the latter is expressed in the U937 cell line. ZNF75A contains five C2H2-type zinc fingers and one KRAB domain. ZNF75A is a nucleus protein, may involves in transcriptional regulation.

VE: 1 * 50 µG

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Artikel-Nr: (PRSI92-145)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 92-145

Lokale Artikelnummer:: PRSI92-145

Beschreibung: Myozenin 2 (MYOZ2) is a 264 amino acid protein that belongs to the myozenin family. MYOZ2 binds to Calcineurin, a phosphatase that is involved in calcium-dependent signal transduction in diverse cell types. MYOZ2 is one of the sarcomeric proteins and plays an important role in myofibrillogenesis and the modulation of calcineurin signalling. It may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and plays an important role in the modulation of calcineurin signalling. Defects in MYOZ2 are the cause of familial hypertrophic cardiomyopathy type 16 (CMH16), a hereditary heart disorder.

VE: 1 * 50 µG

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Artikel-Nr: (PRSI92-142)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 92-142

Lokale Artikelnummer:: PRSI92-142

Beschreibung: Amphiregulin (AREG) is a single-pass membrane protein with 252 amino acids. AREG belongs to the amphiregulin family, which contains 1 EGF-like domain. AREG is expressed in a variety of tissues including ovary, placenta, lung, kidney, stomach, colon, and breast. It is related to Epidermal Growth Factor (EGF) and Transforming Growth Factor Alpha (TGF-alpha). As an EGF-related growth factor, AREG interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. AREG may also play a protective role in Bleomycin-Induced Pneumopathy.

VE: 1 * 50 µG

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Artikel-Nr: (PRSI91-303)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 91-303

Lokale Artikelnummer:: PRSI91-303

Beschreibung: Tumor Necrosis Factor Receptor Superfamily Member 21 (TNFRSF21) is a type I transmembrane receptor that includes four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. DR6 may activate NF-kappa-B and JNK to promote apoptosis and T-cell differentiation. In addition, DR6 binds with N-APP, which is released by the deprivation of Trophic-factor. It triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). DR6 is also expressed on the tumor cell lines and can be induced by TNF- alpha.

VE: 1 * 50 µG

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Artikel-Nr: (PRSI90-427)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 90-427

Lokale Artikelnummer:: PRSI90-427

Beschreibung: T cells require a signal induced by the engagement of the T cell receptor and a costimulatory signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 (PD-L2) is one of two ligands for programmed death-1 (PD-1; CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumour cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.

VE: 1 * 100 µG

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