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controlce
Korrigiert: "controlce"
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Artikel-Nr:
(BOSSBS-12367R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12367R-CY3
Lokale Artikelnummer::
BOSSBS-12367R-CY3
Beschreibung:
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11538R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11538R
Lokale Artikelnummer::
BOSSBS-11538R
Beschreibung:
Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin-dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating the cell cycle by binding to cyclin-Cdk complexes and modulating their activity. CDKL5 (cyclin-dependent kinase-like 5) is a 1030 amino acid protein that belongs to the CMGC Ser/Thr protein kinase family. Expressed in brain, lung, kidney, prostate, ovary, placenta, pancreas and testis, CDKL5 is thought to play a role in cell cycle regulation. Defects in CDKL5 are a cause of several disorders, such as X-linked infantile spasm syndrome and Rett syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12367R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12367R-CY7
Lokale Artikelnummer::
BOSSBS-12367R-CY7
Beschreibung:
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
VE:
1 * 100 µl
Artikel-Nr:
(REST31450)
Lieferant:
Restek
Hersteller-Artikelnummer::
31450
Lokale Artikelnummer::
REST31450
Beschreibung:
EPA method 8330 is used to measure explosives residues in water and soil samples, using HPLC with UV detection. Target analytes are nitroaromatic and nitramine explosives and their degradation products. Obtaining pure, neat compounds for Method 8330 reference standards can be very difficult. To ensure the highest quality standards, Restek's Quality Control (QC) lab confirms the identity and purity of mixture components and solvents using one or more of the following techniques: GC-FID, HPLC, GC-ECD, GC-MS, LC-MS, refractive index, and melting point.
VE:
1 * 1 mL
Artikel-Nr:
(REST31451)
Lieferant:
Restek
Hersteller-Artikelnummer::
31451
Lokale Artikelnummer::
REST31451
Beschreibung:
EPA method 8330 is used to measure explosives residues in water and soil samples, using HPLC with UV detection. Target analytes are nitroaromatic and nitramine explosives and their degradation products. Obtaining pure, neat compounds for Method 8330 reference standards can be very difficult. To ensure the highest quality standards, Restek's Quality Control (QC) lab confirms the identity and purity of mixture components and solvents using one or more of the following techniques: GC-FID, HPLC, GC-ECD, GC-MS, LC-MS, refractive index, and melting point.
VE:
1 * 1 mL
Artikel-Nr:
(BOSSBS-11913R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11913R-CY5
Lokale Artikelnummer::
BOSSBS-11913R-CY5
Beschreibung:
NPDC-1 (Neural Proliferation Differentiation and Control-1) is expressed in neurons once they have stopped dividing and begun to differentiate. NPDC-1 is transported from the Golgi apparatus via vesicles before becoming internalized by endosomes at the cell membrane. NPDC-1 interacts with Cdk2, D-type cyclins, and the transcription factor E2F1. This interaction can lead to an increased replication time, and might have implications in final neural differentiation and apoptosis. NPDC-1 has been shown to colocalize with synaptic vesicle proteins: synaptophysin, synaptobrevin 2, and Rab3 GEP (Rab3 GTP/GDP exchange protein). One function of NPDC-1 is to regulate retinoic acid-mediated events by directly interacting with retinoid receptors. The amino acid sequence of NPDC-1 is highly conserved between mouse, rat, and human.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11586R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11586R-A488
Lokale Artikelnummer::
BOSSBS-11586R-A488
Beschreibung:
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5638R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5638R-FITC
Lokale Artikelnummer::
BOSSBS-5638R-FITC
Beschreibung:
The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non transmembrane PTP, designated SHPTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N terminal to the PTP domain. A second and much more widely expressed PTP with SH2 domains, SHPTP2 (also designated PTP1D and Syp), has been identified. SHP2 is a protein tyrosine phosphatase that is widely expressed and plays a regulatory role in various cell signaling events that are important for many cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11340R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11340R-HRP
Lokale Artikelnummer::
BOSSBS-11340R-HRP
Beschreibung:
The regulated translation of messenger RNA is essential for cell-cycle progression, establishment of the body plan during early development and modulation of key activities in the central nervous system. Cytoplasmic polyadenylation, one mechanism of controlling translation, is driven by cytoplasmic polyadenylation element binding proteins, called CPEBs. CPEB3 (cytoplasmic polyadenylation element binding protein 3) is a 698 amino acid protein that contains two RNA recognition motif (RRM) domains and, like other CPEB proteins, may play a role in the maturation of the central nervous system. CPEB3 exists as multiple alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3404R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3404R-A647
Lokale Artikelnummer::
BOSSBS-3404R-A647
Beschreibung:
The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non transmembrane PTP, designated SHPTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N terminal to the PTP domain. A second and much more widely expressed PTP with SH2 domains, SHPTP2 (also designated PTP1D and Syp), has been identified. SHP2 is a protein tyrosine phosphatase that is widely expressed and plays a regulatory role in various cell signaling events that are important for many cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10271R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10271R-A750
Lokale Artikelnummer::
BOSSBS-10271R-A750
Beschreibung:
The Vav family of Rho guanine nucleotide exchange factors (GEFs) orchestrate Signalling events following lymphocyte antigen receptor activation. Vav3, like Vav (also known as Vav1 or p95Vav), undergoes tyrosine phosphorylation downstream of T cell receptor cross-linkage, and subsequently interacts with 2 adaptor molecules, SLP76 and 3BP2. Following these events, however, the paths of Vav and Vav3 diverge; Vav affects IL-2 promotor activity, while Vav3 impacts gene transcription linked to serum response element (SRE). Furthermore, Vav3 expression follows a cell cycle-dependent pattern, with transient upregulation occurring during mitosis. Enforced Vav3 expression leads to the appearance of multinucleate cells, implicating a role for Vav3 in the control of cytokinesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11599R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11599R-A488
Lokale Artikelnummer::
BOSSBS-11599R-A488
Beschreibung:
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10271R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10271R-A555
Lokale Artikelnummer::
BOSSBS-10271R-A555
Beschreibung:
The Vav family of Rho guanine nucleotide exchange factors (GEFs) orchestrate signaling events following lymphocyte antigen receptor activation. Vav3, like Vav (also known as Vav1 or p95Vav), undergoes tyrosine phosphorylation downstream of T cell receptor cross-linkage, and subsequently interacts with 2 adaptor molecules, SLP76 and 3BP2. Following these events, however, the paths of Vav and Vav3 diverge; Vav affects IL-2 promotor activity, while Vav3 impacts gene transcription linked to serum response element (SRE). Furthermore, Vav3 expression follows a cell cycle-dependent pattern, with transient upregulation occuring during mitosis. Encforced Vav3 expression leads to the appearance of multinucleate cells, implicating a role for Vav3 in the control of cytokinesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3399R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3399R-HRP
Lokale Artikelnummer::
BOSSBS-3399R-HRP
Beschreibung:
The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non transmembrane PTP, designated SHPTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N terminal to the PTP domain. A second and much more widely expressed PTP with SH2 domains, SHPTP2 (also designated PTP1D and Syp), has been identified. SHP2 is a protein tyrosine phosphatase that is widely expressed and plays a regulatory role in various cell signaling events that are important for many cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11586R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11586R-A555
Lokale Artikelnummer::
BOSSBS-11586R-A555
Beschreibung:
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11207R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11207R-A350
Lokale Artikelnummer::
BOSSBS-11207R-A350
Beschreibung:
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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