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6-(Piperidin-1-yl)pyridine-2-carboxaldehyde
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6-(Piperidin-1-yl)pyridine-2-carboxaldehyde
Artikel-Nr:
(BOSSBS-13508R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13508R-CY5
Lokale Artikelnummer::
BOSSBS-13508R-CY5
Beschreibung:
G2A (for G2 accumulation) is a seven transmembrane G protein-coupled receptor that is upregulated in response to DNA damage and stress (1). G2A is predominantly expressed in hematopoietic tissues and in hematopoietic stem cells, and it is more highly detected in pro-B cells, while lower expression is observed in immature B cells and pre-B cells (1,2). G2A is expressed throughout T cell maturation, and it is further increased in response to T-cell activation (3). Ectopic expression of a G2A fusion protein in NIH/3T3 fibroblasts induces a cell cycle arrest that is consistent with a block at the G2/M transition (1,4). G2A is also able to attenuate the proliferative effects of Bcr-Abl, a chimeric tyrosine kinase oncogene, suggesting that G2A possesses anti-oncogenic properties (5). The amino acid sequence of G2A contains a destruction box motif that is consistently observed in cyclins, where it is required for ubiquitination and proteolytic degradation (6).
VE:
1 * 100 µl
Lieferant:
Sigma-Aldrich
Beschreibung:
Highly potent, selective and orally active platelet-activating factor (PAF) receptor antagonist. Ki = 0.6 nM in human platelets.
Lieferant:
MP Biomedicals
Beschreibung:
Menadione belongs to the Vitamin K class of compounds, which are necessary for the biosynthesis of prothrombin and other blood clotting factors. Menadione has demonstrated cytotoxic activity against a variety of cell culture lines and can induce apoptosis of cultured cells, such as osteoclasts and osteoblasts, via elevation of peroxide and superoxide radical levels.
Artikel-Nr:
(REST32444)
Lieferant:
Restek
Hersteller-Artikelnummer::
32444
Lokale Artikelnummer::
REST32444
Beschreibung:
Mix contains Acifluorfen methyl ester, Bentazon methyl ester, Chloramben methyl ester, Dalapon methyl ester, 2,4-D methyl ester, 2,4-DB methyl ester, DCPA methyl ester (Chlorthal-dimethyl), Dicamba methyl ester, 3,5-Dichlorobenzoic acid methyl ester, Dichlorprop methyl ester, Dinoseb methyl ether, Pentachloroanisole, Picloram methyl ester, Quinclorac methyl ester, 2,4,5-T methyl ester, 2,4,5-TP.
VE:
1 * 1 mL
Artikel-Nr:
(BLDPBD01400941-100)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD01400941-100
Lokale Artikelnummer::
BLDPBD01400941-100
Beschreibung:
3-(2-Oxo-1,2-dihydro-4-chinolinyl)-L-alaninhydrochlorid 98% + (contains 10-15% H₂O)
VE:
1 * 100 g
Artikel-Nr:
(1283404.)
Lieferant:
USP
Hersteller-Artikelnummer::
1283404
Lokale Artikelnummer::
USPH1283404
Beschreibung:
USP Reference Standards are specified for use in conducting official USP–NF tests and assays. To confirm accuracy and reproducibility, USP Reference Standards are rigorously tested and evaluated by multiple independent laboratories including USP, commercial, regulatory, and academic labs. USP also provide publicly available, official documentary standards for pharmaceutical ingredients in the USP–NF that link directly with our primary reference standards.
VE:
1 * 200 mg
Artikel-Nr:
(BOSSBS-4296R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4296R-FITC
Lokale Artikelnummer::
BOSSBS-4296R-FITC
Beschreibung:
One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5474R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5474R-HRP
Lokale Artikelnummer::
BOSSBS-5474R-HRP
Beschreibung:
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15165R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15165R-HRP
Lokale Artikelnummer::
BOSSBS-15165R-HRP
Beschreibung:
C3orf14 (chromosome 3 open reading frame 14), also known as HT021, is a 128 amino acid protein that is encoded by a gene mapping to human chromosome 3p14.2. Chromosome 3 is made up of approximately 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15165R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15165R-FITC
Lokale Artikelnummer::
BOSSBS-15165R-FITC
Beschreibung:
C3orf14 (chromosome 3 open reading frame 14), also known as HT021, is a 128 amino acid protein that is encoded by a gene mapping to human chromosome 3p14.2. Chromosome 3 is made up of approximately 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13300R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13300R-CY7
Lokale Artikelnummer::
BOSSBS-13300R-CY7
Beschreibung:
GBE1 is a 702 amino acid protein that is expressed at high levels in muscle and liver and is involved in glycogen biosynthesis. Existing as a monomer, GBE1 catalyzes the transfer of alpha-1,4-linked glucosyl units from the outer end of a glycogen chain to an alpha-1,6 position on a neighboring glycogen chain and, via this catalytic activity, plays an essential role in glycogen accumulation. Defects in the gene encoding GBE1 are the cause of glycogen storage disease type 4 (GSD4) and adult polyglucosan body disease (APBD), the first of which is a metabolic disorder that is associated with the accumulation of polysaccharides and is characterized by liver disease during childhood. Unlike GSD4, APBD is a late-onset disorder that affects the central and peripheral nervous systems and is characterized by cognitive impairment, pyramidal tetraparesis and peripheral neuropathy.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15165R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15165R-A680
Lokale Artikelnummer::
BOSSBS-15165R-A680
Beschreibung:
C3orf14 (chromosome 3 open reading frame 14), also known as HT021, is a 128 amino acid protein that is encoded by a gene mapping to human chromosome 3p14.2. Chromosome 3 is made up of approximately 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13300R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13300R-A750
Lokale Artikelnummer::
BOSSBS-13300R-A750
Beschreibung:
GBE1 is a 702 amino acid protein that is expressed at high levels in muscle and liver and is involved in glycogen biosynthesis. Existing as a monomer, GBE1 catalyzes the transfer of alpha-1,4-linked glucosyl units from the outer end of a glycogen chain to an alpha-1,6 position on a neighboring glycogen chain and, via this catalytic activity, plays an essential role in glycogen accumulation. Defects in the gene encoding GBE1 are the cause of glycogen storage disease type 4 (GSD4) and adult polyglucosan body disease (APBD), the first of which is a metabolic disorder that is associated with the accumulation of polysaccharides and is characterized by liver disease during childhood. Unlike GSD4, APBD is a late-onset disorder that affects the central and peripheral nervous systems and is characterized by cognitive impairment, pyramidal tetraparesis and peripheral neuropathy.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13324R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13324R-CY7
Lokale Artikelnummer::
BOSSBS-13324R-CY7
Beschreibung:
Rab proteins, a family of Ras-related small GTP-binding proteins, play a key role in regulating intracellular vesicle trafficking (1?). Rab GDP dissociation inhibitor (Rab GDI or GDI2) forms a soluble complex with Rab proteins and thereby prevents the exchange of GDP for GTP (1?). In mammals, there exist two major isoforms, Rab GDI alpha (also known as XAP-4) and Rab GDI beta (1,4). While the mammalian Rab GDI beta-genes are ubiquitously expressed, the Rab GDI ?genes are predominantly brain-specific (1). Since it is expressed predominantly in neural and sensory tissues, Rab GDI a may serve a specific function in neural signal transmission (5). The gene sequences for the Rab GDI proteins are extremely conserved in evolution, with substantial homology preserved across three eukaryotic kingdoms (5).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11705R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11705R-CY7
Lokale Artikelnummer::
BOSSBS-11705R-CY7
Beschreibung:
AIP1 (ASK-interacting protein 1), also known as DAB2IP (DAB2 interacting protein), is a 1,189 amino acid protein that localizes to both the membrane and the cytoplasm and contains one Ras-GAP domain, one PH domain and one C2 domain. Expressed at low levels in prostate tissue, AIP1 functions as a Ras GTPase-activating protein that interacts with ASK 1 and, via this interaction, disrupts the association of ASK 1 with an inhibitory 14-3-3 complex, thereby allowing free ASK 1 to function within the cell. AIP1 exists as multiple alternatively spliced isoforms and is down-regulated in prostate cancer tissue, suggesting a role in tumor suppression. Chromosomal aberrations in the gene encoding AIP1 are associated with acute myeloid leukemia (AML), implicating a role for AIP1 fusion proteins in tumorigenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3769R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3769R-CY5.5
Lokale Artikelnummer::
BOSSBS-3769R-CY5.5
Beschreibung:
Modulation of the chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. The N-terminal tail of core histones undergoes different posttranslational modifications including acetylation, phosphorylation and methylation. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression. In most species, the histone H2B is primarily acetylated at lysines 5, 12, 15 and 20. Histone H3 is primarily acetylated at lysines 9, 14, 18 and 23. Acetylation at lysine 9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Phosphorylation at Ser10 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis.
VE:
1 * 100 µl
Preis auf Anfrage
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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