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Methyl-3-fluor-2-nitrobenzoat
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Methyl-3-fluor-2-nitrobenzoat
Artikel-Nr:
(BOSSBS-10228R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10228R-A555
Lokale Artikelnummer::
BOSSBS-10228R-A555
Beschreibung:
The protein encoded by this gene can hydrolyze substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif, which is part of the loop that binds to the substrate. This gene has been found to be a tumor suppressing gene. Several transcript variants, but only one of them protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6140R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6140R-A350
Lokale Artikelnummer::
BOSSBS-6140R-A350
Beschreibung:
S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13025R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13025R-A750
Lokale Artikelnummer::
BOSSBS-13025R-A750
Beschreibung:
Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6057R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6057R-A750
Lokale Artikelnummer::
BOSSBS-6057R-A750
Beschreibung:
Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2379R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2379R-A750
Lokale Artikelnummer::
BOSSBS-2379R-A750
Beschreibung:
Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5637R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5637R-A350
Lokale Artikelnummer::
BOSSBS-5637R-A350
Beschreibung:
SLC29A4 (Solute carrier family 29 (nucleoside transporters), member 4) is involved in the re-uptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It transports serotonin, dopamine and the neurotoxin 1-methyl-4-phenylpyridinium. It may also contribute to the regulation of extracellular adenosine concentrations.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11670R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11670R-A647
Lokale Artikelnummer::
BOSSBS-11670R-A647
Beschreibung:
ESET is a nuclear protein belonging to the histone-lysine methyltransferase family and to the Suvar3-9 subfamily. It is a highly conserved protein of 150 amino acids that has been implicated in chromatin structure modulation. ESET is excluded from cell nucleoli and areas of condensed chromatin and can associate with the nonpericentromeric regions of chromatin. The gene encoding for this protein, SETDB1, maps to chromosome 1q21. ESET is a histone methyltransferase, methylating Lys-9 of histone H3 and mutations within the SETDB1 gene abolishes its methyltransferase activity. This methylation acts as a tag for epigenetic transcriptional repression by rounding up HP1 proteins to methylated histones. ESET is widely expressed with highest levels found in testis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5713R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5713R-A350
Lokale Artikelnummer::
BOSSBS-5713R-A350
Beschreibung:
HOXA5 upregulates both p53 promoter-reporter constructs and endogenous p53 synthesis, leading to apoptosis. HOXA5 is detectable in approximately one-third of primary tumors. Lack of HOXA5 expression strongly correlates with methylation of its promoter region, suggesting a causal role for methylation in the silencing of HOXA5 gene expression. HOXA5 expression is an important step in tumorigenesis and loss of expression of p53 in human breast cancer may be primarily due to lack of expression of HOXA5.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2379R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2379R-A350
Lokale Artikelnummer::
BOSSBS-2379R-A350
Beschreibung:
Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5019R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5019R-A750
Lokale Artikelnummer::
BOSSBS-5019R-A750
Beschreibung:
This gene encodes a mitochondrially localised enzyme that catalyses the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterised by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13025R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13025R-A680
Lokale Artikelnummer::
BOSSBS-13025R-A680
Beschreibung:
Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5637R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5637R-A680
Lokale Artikelnummer::
BOSSBS-5637R-A680
Beschreibung:
SLC29A4 (Solute carrier family 29 (nucleoside transporters), member 4) is involved in the re-uptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It transports serotonin, dopamine and the neurotoxin 1-methyl-4-phenylpyridinium. It may also contribute to the regulation of extracellular adenosine concentrations.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2379R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2379R-A555
Lokale Artikelnummer::
BOSSBS-2379R-A555
Beschreibung:
Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3697R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3697R-A680
Lokale Artikelnummer::
BOSSBS-3697R-A680
Beschreibung:
CTR9 is a component of the PAF (polymerase-associated factor) complex which interacts with histone-modifying enzymes and RNA polymerase II and plays a role in a number of transcription-related processes. Recent studies show that CTR9 can regulate IL-6-responsive gene transcription by influencing histone methylation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5713R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5713R-A680
Lokale Artikelnummer::
BOSSBS-5713R-A680
Beschreibung:
HOXA5 upregulates both p53 promoter-reporter constructs and endogenous p53 synthesis, leading to apoptosis. HOXA5 is detectable in approximately one-third of primary tumors. Lack of HOXA5 expression strongly correlates with methylation of its promoter region, suggesting a causal role for methylation in the silencing of HOXA5 gene expression. HOXA5 expression is an important step in tumorigenesis and loss of expression of p53 in human breast cancer may be primarily due to lack of expression of HOXA5.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11670R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11670R-A488
Lokale Artikelnummer::
BOSSBS-11670R-A488
Beschreibung:
ESET is a nuclear protein belonging to the histone-lysine methyltransferase family and to the Suvar3-9 subfamily. It is a highly conserved protein of 150 amino acids that has been implicated in chromatin structure modulation. ESET is excluded from cell nucleoli and areas of condensed chromatin and can associate with the nonpericentromeric regions of chromatin. The gene encoding for this protein, SETDB1, maps to chromosome 1q21. ESET is a histone methyltransferase, methylating Lys-9 of histone H3 and mutations within the SETDB1 gene abolishes its methyltransferase activity. This methylation acts as a tag for epigenetic transcriptional repression by rounding up HP1 proteins to methylated histones. ESET is widely expressed with highest levels found in testis.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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