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Your search request has been modified to limit number of results. Your search was - N\\\'-[1-Cyclopropylamino-2-phenylethylidene]hydrazinecarboxylic+ac |
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Lieferant:
AESCULAP AG
Beschreibung:
Complete set of uterine dilators.
Artikel-Nr:
(73575-250G)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
73575-250G
Lokale Artikelnummer::
HONC73575-250G
Beschreibung:
Natriumchlorid ≥99,5% für die HPLC, Fluka™
VE:
1 * 250 g
Artikel-Nr:
(BOSSBS-1135R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1135R-CY3
Lokale Artikelnummer::
BOSSBS-1135R-CY3
Beschreibung:
c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3353R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3353R-CY3
Lokale Artikelnummer::
BOSSBS-3353R-CY3
Beschreibung:
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3-proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3353R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3353R-CY5
Lokale Artikelnummer::
BOSSBS-3353R-CY5
Beschreibung:
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3-proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis.
VE:
1 * 100 µl
Lieferant:
DWK Life Sciences
Beschreibung:
Screw thread micro-vials are manufactured from 33 expansion, low extractable borosilicate glass with attached closures.
Artikel-Nr:
(448361000.)
Lieferant:
Thermo Scientific
Hersteller-Artikelnummer::
448361000
Lokale Artikelnummer::
ACRO448361000
Beschreibung:
package of 4x25ML bottles
VE:
1 * 100 mL
Lieferant:
Sigma-Aldrich
Beschreibung:
L(+)-Kaliumhydrogentartrat, Sigma-Aldrich®
Lieferant:
Sigma-Aldrich
Beschreibung:
L(+)-Kaliumhydrogentartrat, Sigma-Aldrich®
Lieferant:
Thermo Scientific
Beschreibung:
1-(2,4-Dichlorphenyl)-2-thioharnstoff
Lieferant:
FLUOROCHEM
Beschreibung:
1-(2,4-Dichlorphenyl)-2-thioharnstoff
Artikel-Nr:
(APPC121719.1211)
Lieferant:
APPLICHEM
Hersteller-Artikelnummer::
121719.1211
Lokale Artikelnummer::
APPC121719.1211
Beschreibung:
di-Natrium-L(+)-tartrat Dihydrat 99,0-101,0% (durch Perchlorsäure-Titration) Reag. Ph. Eur.
VE:
1 * 1.000 g
Artikel-Nr:
(481-4700)
Lieferant:
HMC Europe GmbH
Hersteller-Artikelnummer::
20000
Lokale Artikelnummer::
HMCA20000
Beschreibung:
The four HV models are simple and robost which consists of a quicklock, dual sensor system, themolock and a exhaust air filter and are used for higher standards.
VE:
1 * 1 ST
Lieferant:
Sigma-Aldrich
Beschreibung:
Diglycolsäureanhydrid, Sigma-Aldrich®
Lieferant:
Bernd Kraft
Beschreibung:
Amidoschwefelsäure, reinst
Lieferant:
Sigma-Aldrich
Beschreibung:
di-Natrium-L(+)-tartrat Dihydrat, Sigma-Aldrich®
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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