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Naphthol+AS-BI-phosphat+Dinatriumsalz
Artikel-Nr:
(BOSSBS-7545R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7545R-CY5.5
Lokale Artikelnummer::
BOSSBS-7545R-CY5.5
Beschreibung:
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII and SR-BI are identical except for the encoded c-terminal cytoplasmic domain. Both SR-BI and SR-BII bind HDL and mediates selective uptake of HDL cholesteryl ester, but with SR-BII having an approximately 4-fold lower efficiency than SR-BI. SR-BI and SR-BII are expressed primarily in liver and non-placental steroidgenic tissues. Although the role of these scavenger receptors is not completely clear, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with both isoforms mediating selective transfer of lipid between HDL and cells. Therefore, the relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7048R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7048R-HRP
Lokale Artikelnummer::
BOSSBS-7048R-HRP
Beschreibung:
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling. Regulates cell adhesion and cell spreading. Required for HGF-mediated lamellipodium formation, cell scattering and spreading. Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation. Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Involved in EGF signaling pathway. Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3. Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7048R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7048R-CY5.5
Lokale Artikelnummer::
BOSSBS-7048R-CY5.5
Beschreibung:
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling. Regulates cell adhesion and cell spreading. Required for HGF-mediated lamellipodium formation, cell scattering and spreading. Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation. Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Involved in EGF signaling pathway. Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3. Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity.
VE:
1 * 100 µl
Artikel-Nr:
(BLDPBD150358-5G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD150358-5G
Lokale Artikelnummer::
BLDPBD150358-5G
Beschreibung:
Rhodamin B 97%
VE:
1 * 5 g
Lieferant:
Alfa Aesar
Beschreibung:
2,5-Dithiobiurea 97%
Artikel-Nr:
(M197-500ML)
Lieferant:
VWR Chemicals
Lokale Artikelnummer::
VWRCM197-500ML
Beschreibung:
4X concentrated buffer solution (1,5 M Tris, pH 8,8 and 0,4% SDS). Used for preparation of standard acrylamide:bis-acrylamide gels as well as preparation of gels using PAGE-PLUS™ acrylamide solution.
VE:
1 * 500 mL
Artikel-Nr:
(PRSI26-612)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
26-612
Lokale Artikelnummer::
PRSI26-612
Beschreibung:
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities.4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI31-038)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
31-038
Lokale Artikelnummer::
PRSI31-038
Beschreibung:
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined.
VE:
1 * 50 µG
Lieferant:
JSP
Beschreibung:
A range of vertical fold-flat disposable masks with unique bi-directional filter material, allowing freedom of movement and easy communication.
Lieferant:
Alfa Aesar
Beschreibung:
Diisopropanolamin Summe der Isomere ≥98%
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
(Ir[dF(CF3)ppy]2(dtbpy))PF6 98%
Artikel-Nr:
(87811.180)
Lieferant:
VWR Chemicals
Lokale Artikelnummer::
VWRC87811.180
Beschreibung:
Kristallviolett-Lösung Reag. Ph. Eur. 1022901
VE:
1 * 100 mL
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 146724-94-9
Artikel-Nr:
(APOSOR7669-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR7669-1G
Lokale Artikelnummer::
APOSOR7669-1G
Beschreibung:
2,4-Dibenzyloxy-5-pyrimidinboronsäure
VE:
1 * 1 g
Lieferant:
BIOMOL RESEARCH LABORATORIES
Beschreibung:
Bisacrylamid, 4x kristallisiert
Lieferant:
Thermo Scientific
Beschreibung:
Divalproex sodium
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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