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[2-(4-Bromobenzyl)thiazol-4-y]acetic+acid
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[2-(4-Bromobenzyl)thiazol-4-y]acetic+acid
Artikel-Nr:
(ROCK606-1603)
Lieferant:
Rockland Immunochemicals
Hersteller-Artikelnummer::
606-1603
Lokale Artikelnummer::
ROCK606-1603
Beschreibung:
This product has been assayed against 1.0 µg of Guinea Pig IgG in a standard capture ELISA using Peroxidase Conjugated Streptavidin and ABTS (2,2’-azino-bis-(3-ethylbenthiazoline-6-sulfonic acid)) as a substrate for 30 minutes at room temperature.
VE:
1 * 2 mg
Artikel-Nr:
(ROCK100-401-046)
Lieferant:
Rockland Immunochemicals
Hersteller-Artikelnummer::
100-401-046
Lokale Artikelnummer::
ROCK100-401-046
Beschreibung:
This product has been assayed against 1.0 µg of Alpha-1-Acid GlycoProtein (Human Plasma) in a standard ELISA using Peroxidase conjugated Affinity Purified anti-Rabbit IgG (H&L) (Goat) and ABTS (2,2’-azino-bis-(3-ethylbenthiazoline-6-sulfonic acid))
VE:
1 * 2 mL
Artikel-Nr:
(ROCK205-4307)
Lieferant:
Rockland Immunochemicals
Hersteller-Artikelnummer::
205-4307
Lokale Artikelnummer::
ROCK205-4307
Beschreibung:
This product has been assayed against 1.0 µg of Goat IgM in a standard capture ELISA using ABTS (2,2’-azino-bis-(3-ethylbenthiazoline-6-sulfonic acid)) as a substrate for 30 minutes at room temperature.
VE:
1 * 20 mg
Artikel-Nr:
(ROCK602-1302)
Lieferant:
Rockland Immunochemicals
Hersteller-Artikelnummer::
602-1302
Lokale Artikelnummer::
ROCK602-1302
Beschreibung:
This product has been assayed against 1.0 µg of Cat IgG in a standard capture ELISA using ABTS (2,2’-azino-bis-(3-ethylbenthiazoline-6-sulfonic acid)) as a substrate for 30 minutes at room temperature.
VE:
1 * 2 mg
Artikel-Nr:
(ROCK100-4175)
Lieferant:
Rockland Immunochemicals
Hersteller-Artikelnummer::
100-4175
Lokale Artikelnummer::
ROCK100-4175
Beschreibung:
Anti-PENICILLINASE Antibody has been assayed against 1.0 µg of Penicillinase (Enterobacter cloacae) in a standard ELISA using Peroxidase conjugated Affinity Purified anti-Rabbit IgG (H&L) (Goat) using ABTS (2,2’-azino-bis-(3-ethylbenthiazoline-6-sulfonic acid))
VE:
1 * 2 mL
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
Mixture of 97% 1,2-isomer; balance 1,3-isomer
Artikel-Nr:
(BOSSBS-3495R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3495R-A647
Lokale Artikelnummer::
BOSSBS-3495R-A647
Beschreibung:
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3494R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3494R-A680
Lokale Artikelnummer::
BOSSBS-3494R-A680
Beschreibung:
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5587R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5587R-CY7
Lokale Artikelnummer::
BOSSBS-5587R-CY7
Beschreibung:
Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration.
VE:
1 * 100 µl
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
[1-(4,6-Dimethyl-2-pyrimidinyl)-5-(hydroxymethyl)-1H-1,2,3-triazol-4-yl]methanol
Artikel-Nr:
(ACRO427880010)
Lieferant:
Thermo Scientific
Hersteller-Artikelnummer::
427880010
Lokale Artikelnummer::
ACRO427880010
Beschreibung:
Appearance: White Crystalline powder
VE:
1 * 1 g
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
Under Mitsunobu conditions primary and secondary alcohols can be protected as hexafluorophenylisopropyl(HIP) ethers: J. Am. Chem. Soc., 116, 8354 (1994).
Artikel-Nr:
(BOSSBS-3390R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3390R-CY3
Lokale Artikelnummer::
BOSSBS-3390R-CY3
Beschreibung:
Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.
VE:
1 * 100 µl
Lieferant:
Alfa Aesar
Beschreibung:
N,N'-Dimethylethylendiamin 95%
Artikel-Nr:
(BOSSBS-3494R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3494R-CY5
Lokale Artikelnummer::
BOSSBS-3494R-CY5
Beschreibung:
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1.
VE:
1 * 100 µl
Lieferant:
Alfa Aesar
Beschreibung:
HATU (O-(7-Aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluroniumhexafluorophosphat) ≥99%
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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