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Pyrazolo[1,5-a]pyrimidin-7(4H)-one
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Pyrazolo[1,5-a]pyrimidin-7(4H)-one
Lieferant:
Thermo Scientific
Beschreibung:
Methylcellulose, 15 cP (2% H₂O)
Lieferant:
VWR Chemicals
Beschreibung:
VWR® Chemicals ISO 17025/ISO 17034 dual certified-density standards are for the verification of instruments used to measure the density of materials which are fluid at the desired test temperature.
Lieferant:
Alfa Aesar
Beschreibung:
Nickel ≥99,8% (Metall-Basis), sphärische Pulver, APS 5-15 µm
Lieferant:
Bertin Instruments
Beschreibung:
15 ml holder (adapter and blocking plate) for 6×15 ml lysis tubes, Für: Precellys® Evolution
Lieferant:
VWR Collection
Beschreibung:
Vertikale Gelelektrophorese-System, Zubehörteil, Kamm, 5 Taschen, 1,5 mm stark, Für: Mini vertical PAGE system, shiroGEL
Lieferant:
Alfa Aesar
Beschreibung:
Aluminium ≥99,9% (Metall-Basis), unregelmäßige Granalien ≤ 15 mm
Artikel-Nr:
(459-4501)
Lieferant:
VWR Collection
Lokale Artikelnummer::
VWRI459-4501
Beschreibung:
Schmelztiegel aus Edelstahl 304.
VE:
1 * 1 ST
Lieferant:
Alfa Aesar
Beschreibung:
Gold ≥99,96% (Metall-Basis), sphärische Pulver APS 1,5-3,0 µm
Artikel-Nr:
(216-0174)
Lieferant:
VWR Collection
Lokale Artikelnummer::
VWRI216-0174
Beschreibung:
PTFE, mit Ausguss.
VE:
1 * 1 ST
Artikel-Nr:
(BOSSBS-6634R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6634R-CY5
Lokale Artikelnummer::
BOSSBS-6634R-CY5
Beschreibung:
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6634R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6634R-A647
Lokale Artikelnummer::
BOSSBS-6634R-A647
Beschreibung:
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
VE:
1 * 100 µl
Artikel-Nr:
(MFLX74445-93)
Lieferant:
Avantor Fluid Handling
Lokale Artikelnummer::
MFLA74445-93
Beschreibung:
Verlängern Sie die Haltbarkeit Ihrer Zahnrad-Pumpenkopfes mit diesen Servicekits.
VE:
1 * 1 ST
Lieferant:
Alfa Aesar
Beschreibung:
Tantal ≥99,95% (Metall-Basis), Folie, Dicke 1.5 mm (0.06 in)
Artikel-Nr:
(APOSOR015010-5G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR015010-5G
Lokale Artikelnummer::
APOSOR015010-5G
Beschreibung:
7-Bromochroman-4-one
VE:
1 * 5 g
Artikel-Nr:
(87827.180)
Lieferant:
VWR Chemicals
Lokale Artikelnummer::
VWRC87827.180
Beschreibung:
Starting materials: Dithizone R / Chloroform R
VE:
1 * 100 mL
Lieferant:
VWR Collection
Beschreibung:
VWR®, Chromatographieampullen-Verschlüsse, Screw caps with septa, open top, 10-425 thread, Härte: 45° shore A, Septum: White silicone/beige PTFE, Stärke: 1,5 mm
Preis auf Anfrage
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
Dieses Produkt wurde von Ihrer Organisation gesperrt. Bitte kontaktieren Sie Ihren Einkauf für weitere Informationen.
Dieses Produkt ist Ersatz für den von Ihnen gewünschten Artikel.
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