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Pyridin-N-oxid
Artikel-Nr:
(APOSPC440006-250MG)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC440006-250MG
Lokale Artikelnummer::
APOSPC440006-250MG
Beschreibung:
(R)-3,3'-Bis(3,5-difluorophenyl)-1,1'-binapthyl-2,2'-diyl hydrogenphosphate
VE:
1 * 250 mg
Artikel-Nr:
(11160.QH)
Lieferant:
Alfa Aesar
Hersteller-Artikelnummer::
11160.QH
Lokale Artikelnummer::
ALFA11160.QH
Beschreibung:
di-Bortrioxid, getrocknet (max. 0,02% H₂O) ≥99,999% (Metall-Basis), Puratronic®
VE:
1 * 10 ST
Artikel-Nr:
(BLDPBD155442-100G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD155442-100G
Lokale Artikelnummer::
BLDPBD155442-100G
Beschreibung:
Trimethylphosphat 99.5%
VE:
1 * 100 g
Artikel-Nr:
(BOSSBS-13694R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13694R-A350
Lokale Artikelnummer::
BOSSBS-13694R-A350
Beschreibung:
NOSTRIN (nitric oxide synthase trafficker isoform 1), also known as endothelial nitric oxide synthase traffic inducer, is a member of the Pombe Cdc15 homology (PCH) family of proteins. NOSTRIN is expressed in the vascular endothelial cells of highly vascularized tissues such as placenta, lung, kidney and heart. It consists of an N-terminal Cdc15 domain with an FCH (Fes/CIP homology) region, two coiled coil domains and a C-terminal SH3 domain. NOSTRIN typically exists as a trimer. It functions as an adaptor protein binding to caveolin-1 via an internal domain and NOS3 via its SH3 domain, forming a ternary complex which facilitates caveolar transport of NOS3. The NOS3 protein is responsible for the production of nitric oxide (NO), a potent mediator in various biological processes. The translocation of NOS3 from the plasma membrane to intracellular vesicle-like structures diminishes NO production. NOSTRIN also interacts with Dynamin and N-WASP via its SH3 domain.
VE:
1 * 100 µl
Lieferant:
Alfa Aesar
Beschreibung:
Certrinitrat Hexahydrat ≥99,5% (REO, Basis der Oxide der Metalle der seltenen Erden), REacton®
Artikel-Nr:
(BOSSBS-8552R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8552R-HRP
Lokale Artikelnummer::
BOSSBS-8552R-HRP
Beschreibung:
Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro).Involvement in disease;Defects in XDH are the cause of xanthinuria type 1 (XU1) . Xanthinuria is characterized by excretion of very large amounts of xanthine in the urine and a tendency to form xanthine stones. Uric acid is strikingly diminished in serum and urine. XU1 is due to isolated xanthine dehydrogenase. XU1 patients can metabolize allopurinol.
VE:
1 * 100 µl
Artikel-Nr:
(1546853.)
Lieferant:
USP
Hersteller-Artikelnummer::
1546853
Lokale Artikelnummer::
USPH1546853
Beschreibung:
USP Reference Standards are specified for use in conducting official USP–NF tests and assays. USP also provides Reference Standards specified in the Food Chemicals Codex as well as authentic substances—high-quality chemical samples—as a service to analytical, clinical, pharmaceutical and research laboratories. To confirm accuracy and reproducibility, USP Reference Standards are rigorously tested and evaluated by multiple independent laboratories including USP, commercial, regulatory, and academic labs. USP also provide publicly available, official documentary standards for pharmaceutical ingredients in the USP–NF that link directly with our primary reference standards.
VE:
1 * 100 mg
Artikel-Nr:
(VWRS83927.410)
Lieferant:
VWR Collection
Lokale Artikelnummer::
VWRS83927.410
Beschreibung:
4-(Dimethylamino)pyridin 14,5 g/l THF, VOLUSOL®
VE:
1 * 10 L
Artikel-Nr:
(BOSSBS-2537R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2537R-CY5.5
Lokale Artikelnummer::
BOSSBS-2537R-CY5.5
Beschreibung:
Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2537R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2537R-A488
Lokale Artikelnummer::
BOSSBS-2537R-A488
Beschreibung:
Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6988R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6988R-CY5.5
Lokale Artikelnummer::
BOSSBS-6988R-CY5.5
Beschreibung:
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.Sequence similarities: Belongs to the RuBisCO large chain family. Type I subfamily.Post-translational modifications: The disulfide bond which can form between Cys-247 in the large chain dimeric partners within the hexadecamer appears to be associated with oxidative stress and protein turnover (By similarity). The disulfide bonds reported in 1RBO may be the result of oxidation during crystallization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6988R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6988R-A680
Lokale Artikelnummer::
BOSSBS-6988R-A680
Beschreibung:
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.Sequence similarities: Belongs to the RuBisCO large chain family. Type I subfamily.Post-translational modifications: The disulfide bond which can form between Cys-247 in the large chain dimeric partners within the hexadecamer appears to be associated with oxidative stress and protein turnover (By similarity). The disulfide bonds reported in 1RBO may be the result of oxidation during crystallisation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6988R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6988R-A350
Lokale Artikelnummer::
BOSSBS-6988R-A350
Beschreibung:
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.Sequence similarities: Belongs to the RuBisCO large chain family. Type I subfamily.Post-translational modifications: The disulfide bond which can form between Cys-247 in the large chain dimeric partners within the hexadecamer appears to be associated with oxidative stress and protein turnover (By similarity). The disulfide bonds reported in 1RBO may be the result of oxidation during crystallization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13694R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13694R-A680
Lokale Artikelnummer::
BOSSBS-13694R-A680
Beschreibung:
NOSTRIN (nitric oxide synthase trafficker isoform 1), also known as endothelial nitric oxide synthase traffic inducer, is a member of the Pombe Cdc15 homology (PCH) family of proteins. NOSTRIN is expressed in the vascular endothelial cells of highly vascularized tissues such as placenta, lung, kidney and heart. It consists of an N-terminal Cdc15 domain with an FCH (Fes/CIP homology) region, two coiled coil domains and a C-terminal SH3 domain. NOSTRIN typically exists as a trimer. It functions as an adaptor protein binding to caveolin-1 via an internal domain and NOS3 via its SH3 domain, forming a ternary complex which facilitates caveolar transport of NOS3. The NOS3 protein is responsible for the production of nitric oxide (NO), a potent mediator in various biological processes. The translocation of NOS3 from the plasma membrane to intracellular vesicle-like structures diminishes NO production. NOSTRIN also interacts with Dynamin and N-WASP via its SH3 domain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4206R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4206R-CY5
Lokale Artikelnummer::
BOSSBS-4206R-CY5
Beschreibung:
Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
VE:
1 * 100 µl
Artikel-Nr:
(L00510.09)
Lieferant:
Alfa Aesar
Hersteller-Artikelnummer::
L00510.09
Lokale Artikelnummer::
ALFAL00510.09
Beschreibung:
Methyl (methylsulphinyl)methyl sulphide 97%
VE:
1 * 10 g
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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