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Pyridin-N-oxid
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Pyridin-N-oxid
Artikel-Nr:
(BOSSBS-13544R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13544R-A647
Lokale Artikelnummer::
BOSSBS-13544R-A647
Beschreibung:
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble forms, known as GCS or sGC, act as receptors for nitric oxide. The membrane-bound receptor forms, known as GC, are peptide hormone receptors. GCS, a cGMP-synthesizing enzyme, is the major receptor for the neurotransmitter nitric oxide (NO). It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme containing heterodimer, consisting of one alpha subunit, designated GCS-alpha-1, and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide, which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both the alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity.
VE:
1 * 100 µl
Artikel-Nr:
(APOSPC408822-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC408822-1G
Lokale Artikelnummer::
APOSPC408822-1G
Beschreibung:
5-Chloro-2-(pentafluoroethyl)pyridine
VE:
1 * 1 g
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
2-Hydrazino-3-(trifluoromethyl)pyridine
Artikel-Nr:
(BOSSBS-3447R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3447R-A680
Lokale Artikelnummer::
BOSSBS-3447R-A680
Beschreibung:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3572R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3572R-HRP
Lokale Artikelnummer::
BOSSBS-3572R-HRP
Beschreibung:
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3410R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3410R-A488
Lokale Artikelnummer::
BOSSBS-3410R-A488
Beschreibung:
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6592R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6592R-CY5.5
Lokale Artikelnummer::
BOSSBS-6592R-CY5.5
Beschreibung:
NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.Tissue specificity; Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain.Sequence similarities; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
VE:
1 * 100 µl
Artikel-Nr:
(APOSOR14219-250MG)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR14219-250MG
Lokale Artikelnummer::
APOSOR14219-250MG
Beschreibung:
5-Amino-2-(4-methoxyphenyl)pyridin
VE:
1 * 250 mg
Artikel-Nr:
(BOSSBS-3140R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3140R-A680
Lokale Artikelnummer::
BOSSBS-3140R-A680
Beschreibung:
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognises and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34C expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3140R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3140R-FITC
Lokale Artikelnummer::
BOSSBS-3140R-FITC
Beschreibung:
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5015R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5015R-A647
Lokale Artikelnummer::
BOSSBS-5015R-A647
Beschreibung:
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1548R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1548R-A488
Lokale Artikelnummer::
BOSSBS-1548R-A488
Beschreibung:
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. recognises and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34C expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
VE:
1 * 100 µl
Artikel-Nr:
(APOSPC9263-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC9263-1G
Lokale Artikelnummer::
APOSPC9263-1G
Beschreibung:
2-Hydroxy-6-(trifluormethyl)pyridin
VE:
1 * 1 g
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
4-(Biphenyl-4-yl)pyridine
Artikel-Nr:
(USBI039553-BIOTIN)
Lieferant:
US Biological
Hersteller-Artikelnummer::
039553-BIOTIN
Lokale Artikelnummer::
USBI039553-BIOTIN
Beschreibung:
Anti-OXR1 Rabbit Polyclonal Antibody (Biotin)
VE:
1 * 200 µl
Artikel-Nr:
(BOSSBS-4730R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4730R-A647
Lokale Artikelnummer::
BOSSBS-4730R-A647
Beschreibung:
Nox4 is a renal gp91-phox homolog highly expressed at the site of erythropoietin production in the proximal convoluted tubule epithelial cells of the renal cortex. Nox4 is also expressed in fetal tissues, placenta, glioblastoma and vascular cells. Like gp91-phox, the enzymatic activity of Nox4 produces superoxide anions. In vascular cells, the addition of angiotensin II increases Nox4 expression, which suggests a role for Nox-4 in vascular oxidative stress response.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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