Pyridin-N-oxid
Artikel-Nr:
(BOSSBS-0267R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0267R
Lokale Artikelnummer::
BOSSBS-0267R
Beschreibung:
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4.
VE:
1 * 100 µl
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
Zirkonylnitrat Hydrat
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
Furo[3,2-b]pyridine
Artikel-Nr:
(APOSPC510237-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC510237-1G
Lokale Artikelnummer::
APOSPC510237-1G
Beschreibung:
2-(Aminomethyl)-6-(trifluoromethyl)pyridine
VE:
1 * 1 g
Lieferant:
Thermo Scientific
Beschreibung:
Pyridin 99+% zur Analyse
Artikel-Nr:
(BOSSBS-3589R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3589R-A488
Lokale Artikelnummer::
BOSSBS-3589R-A488
Beschreibung:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. May play a significant role in normal and abnormal limb development.
VE:
1 * 100 µl
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
4-Bromo-2-(1-hydroxyethyl)pyridine
Artikel-Nr:
(BOSSBS-3447R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3447R-FITC
Lokale Artikelnummer::
BOSSBS-3447R-FITC
Beschreibung:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3447R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3447R-A488
Lokale Artikelnummer::
BOSSBS-3447R-A488
Beschreibung:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3731R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3731R-A647
Lokale Artikelnummer::
BOSSBS-3731R-A647
Beschreibung:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0163R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0163R-HRP
Lokale Artikelnummer::
BOSSBS-0163R-HRP
Beschreibung:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
VE:
1 * 100 µl
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
2-(1-Hydroxyethyl)pyridin
Artikel-Nr:
(USBI035076-BIOTIN)
Lieferant:
US Biological
Hersteller-Artikelnummer::
035076-BIOTIN
Lokale Artikelnummer::
USBI035076-BIOTIN
Beschreibung:
Anti-NOS3 Rabbit Polyclonal Antibody (Biotin)
VE:
1 * 200 µl
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
2-Fluoro-5-(4-methoxyphenyl)pyridine
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
2-Fluoro-4-(methylthio)pyridine
Artikel-Nr:
(APOSPC510045-5G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC510045-5G
Lokale Artikelnummer::
APOSPC510045-5G
Beschreibung:
2-(3-Fluorophenyl)-5-(hydroxymethyl)pyridine
VE:
1 * 5 g
Preis auf Anfrage
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