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Pyridin-N-oxid
Artikel-Nr:
(BOSSBS-10521R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10521R-CY3
Lokale Artikelnummer::
BOSSBS-10521R-CY3
Beschreibung:
Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1446R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1446R-CY7
Lokale Artikelnummer::
BOSSBS-1446R-CY7
Beschreibung:
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilisation of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3410R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3410R-CY3
Lokale Artikelnummer::
BOSSBS-3410R-CY3
Beschreibung:
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2766R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2766R-A680
Lokale Artikelnummer::
BOSSBS-2766R-A680
Beschreibung:
FOXO1 is a transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.
FOXO4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.
VE:
1 * 100 µl
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
3-Bromo-5-(trifluoromethyl)pyridin-2-ol
Artikel-Nr:
(BOSSBS-11277R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11277R-A647
Lokale Artikelnummer::
BOSSBS-11277R-A647
Beschreibung:
DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11277R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11277R-FITC
Lokale Artikelnummer::
BOSSBS-11277R-FITC
Beschreibung:
DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13544R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13544R-A647
Lokale Artikelnummer::
BOSSBS-13544R-A647
Beschreibung:
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble forms, known as GCS or sGC, act as receptors for nitric oxide. The membrane-bound receptor forms, known as GC, are peptide hormone receptors. GCS, a cGMP-synthesizing enzyme, is the major receptor for the neurotransmitter nitric oxide (NO). It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme containing heterodimer, consisting of one alpha subunit, designated GCS-alpha-1, and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide, which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both the alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity.
VE:
1 * 100 µl
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
2-Fluor-5-(trifluormethyl)pyridin 97%
Artikel-Nr:
(APOSPC408811-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC408811-1G
Lokale Artikelnummer::
APOSPC408811-1G
Beschreibung:
2-Chloro-3-(pentafluoroethyl)pyridine
VE:
1 * 1 g
Artikel-Nr:
(APOSPC408809-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC408809-1G
Lokale Artikelnummer::
APOSPC408809-1G
Beschreibung:
2-Chloro-4-(pentafluoroethyl)pyridine
VE:
1 * 1 g
Artikel-Nr:
(BOSSBS-1074R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1074R-A680
Lokale Artikelnummer::
BOSSBS-1074R-A680
Beschreibung:
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-14133R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-14133R-A750
Lokale Artikelnummer::
BOSSBS-14133R-A750
Beschreibung:
NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.
VE:
1 * 100 µl
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
4-(Trifluoromethyl)pyridine-3-carboxamideoxime
Artikel-Nr:
(BOSSBS-4047R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4047R-CY5.5
Lokale Artikelnummer::
BOSSBS-4047R-CY5.5
Beschreibung:
ACADM protein is a medium chain specific (C4 to C12 straight chain) acyl Coenzyme A dehydrogenase. The enzyme catalyzes the initial step of the mitochondrial fatty acid beta oxidation pathway. ACADM expression is induced during periods of fasting, when reliance on fatty acids for energy is increased. Clinical phenotypes are associated with ACADM hereditary deficiency.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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