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4,4,4-Trifluoro-3-(trifluoromethyl)butanoic+acid
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4,4,4-Trifluoro-3-(trifluoromethyl)butanoic+acid
Artikel-Nr:
(BOSSBS-9682R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9682R-A647
Lokale Artikelnummer::
BOSSBS-9682R-A647
Beschreibung:
C19orf46 is a 404 amino acid single-pass type IV membrane protein that belongs to the nesprin family. C19orf46 partcipates in the establishment of secretory epithelial morphology by inducing kinesin-dependent apical migration of the centrosome and Golgi apparatus as well as basal localization of the nucleus. C19orf46 interacts with UKHC and KCL1, and exists as two alternatively spliced isoforms. C19orf46 contains a KASH domain, which consists of a transmembrane motif, mediates nuclear enevelop targeting and binds to the SUN domain of SUN1 and SUN2. C19orf46 is encoded by a gene located on human chromosome 19, which consists of approximately 63 million bases and makes up over 2% of human genomic DNA.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13736R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13736R-CY7
Lokale Artikelnummer::
BOSSBS-13736R-CY7
Beschreibung:
ADAM13 was first described as a protein expressed in somatic mesoderm and neural crest cells, in developing Xenopus embryos. ADAM13 was also found in liver, heart, and intestines from adult Xenopus. ADAM13 may regulate cellular signaling via Src and Src tyrosine kinase. ADAM13 may also act as a cell attachment molecule, by binding integrins through the cysteine rich domain amoung many other roles. A member of the metalloproteinase family containing disintegrin like domains (ADAMs) the functions of ADAM13 are still poorly understood. ADAM13 contains the canonical HExxHxxxxxH zinc metalloproteinase motif, as well as disintegrin, cysteine rich, EFG like, transmembrane and Cytoplasmic domains. ADAM13 has been shown to be proteolytically active, cleaving fibronectin after binding it to the EGF like domain. ADAM13 is also shed from cells in culture, cleaved aminoterminal from the transmembrane domain, and is released into the culture media. Shed ADAM13 is a 52 kD protein, and can form complexes with a2 macroglobulin, suggesting it is a competent protease. Xenopus ADAM13 has greatest homology with human ADAM 33 (51% identical), and is 46% identical with human or mouse ADAM12 or ADAM19. It is still unclear if any of these ADAMs are species orthologs of Xenopus ADAM13, but there are significant differences between the related sequences, suggesting that ADAM13 may be a unique protein. The full length Xenopus ADAM13 sequence codes for a 914 amino acid protein. Predicted mass is 99.749 kD, but glycosylation and cyteine rich regions give Xenopus ADAM13 an apparent MW of 120 kD unprocessed, and 97 kD processed forms, on reduced SDS PAGE gels. ADAM13 contains a putative furin cleavage site, suggesting that a prohormone convertase cleaves the propeptide domain away from the catalytic domain
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4299R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4299R-A750
Lokale Artikelnummer::
BOSSBS-4299R-A750
Beschreibung:
CNTROB is a centrosomal protein that interacts with BRCA2 and is required for centriole duplication with inhibition of centriole duplication leading to defects in cytokinesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1520R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1520R-CY5
Lokale Artikelnummer::
BOSSBS-1520R-CY5
Beschreibung:
CD7 is a 40 kDa transmembrane, single-chain glycoprotein, which is a member of the immunoglobulin superfamily. CD7 is expressed by the majority of thymocytes and mature T cells, NK cells and pre-B cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development. The function of CD7 is not yet known although cross-linking of CD7 with induces a T cell transmembrane calcium flux and CD7 expression is induced by ionomycin. The CD7 molecule has been reported to be the receptor for the IgM-Fc portion (FcR mu) on the surface of T cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1616R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1616R-CY3
Lokale Artikelnummer::
BOSSBS-1616R-CY3
Beschreibung:
CAP2 is a identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein and actin.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6672R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6672R-A750
Lokale Artikelnummer::
BOSSBS-6672R-A750
Beschreibung:
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterised by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6710R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6710R-A750
Lokale Artikelnummer::
BOSSBS-6710R-A750
Beschreibung:
NGL-1 is a single pass type I membrane protein that acts as a cell adhesion molecule. It contains nine leucine-rich repeats (LRR) and one Ig-like C2-type domain. NGL-1 is predominantly expressed in the striatum and the cerebral cortex of both the embryonic and adult brain. NGL-1 specifically interacts with Netrin G1 (a molecule involved in axon guidance in the developing central nervous system) via its LRR region. NGL-1 plays a role in the regulation of neurite outgrowth of developing thalamic neurons. Soluble NGL-1 inhibits thalamic axon outgrowth while NGL-1 that is bound to the surface of developing thalamocortical axons stimulates growth. NGL-1 also interacts with Whirlin possibly stablising interstereociliar links.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6471R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6471R-A750
Lokale Artikelnummer::
BOSSBS-6471R-A750
Beschreibung:
Inositol 1,4,5-triphosphate (IP3) functions as a second messenger for a myriad of extracellular stimuli including hormones, growth factors and neurotransmitters. Receptor tyrosine kinases indirectly increase the intracellular levels of IP3 through the activation of phospholipases such as phospholipase C (PLC), which convert phosphatidylinositol-4,5 bisphosphate into IP3 and diacylglycerol (DAG). The inositol 1,4,5-triphosphate receptor, IP3R, acts as an inositol triphosphate (IP3)-gated calcium release channel in a variety of cell types. Three IP3 receptor subtypes have been described and are designated IP3R-I, IP3R-II and IP3R-III. IP3R-I is the predominant IP3R subtype expressed in neuronal tissues and the central nervous system, but is also expressed at high levels in the liver.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9498R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9498R-A680
Lokale Artikelnummer::
BOSSBS-9498R-A680
Beschreibung:
C9orf153 is a 101 amino acid protein that exists as two alternatively spliced isoforms. The gene encoding C9orf153 maps to human chromosome 9q21.33. Chromosome 9 consists of about 145 million bases, represents 4% of the human genome and encodes nearly 900 genes. Thought to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterised by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukaemias.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11110R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11110R-A750
Lokale Artikelnummer::
BOSSBS-11110R-A750
Beschreibung:
Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDH17 is a 1159 amino acid single-pass type I membrane protein that contains six cadherin domains. Expressed as multiple alternatively spliced isoforms, PCDH17 is thought to function as a calcium-dependent cell adhesion protein that may play a role in establishing cell-cell connections within brain tissue. The gene encoding PCDH17 maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9689R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9689R-A680
Lokale Artikelnummer::
BOSSBS-9689R-A680
Beschreibung:
TWA1 is a 228 amino acid nuclear protein that is highly conserved throughout evolution. TWA1 interacts with Ran BP-M, a protein that is implicated in a diverse array of cellular processes including DNA replication, entry into and exit from mitosis, and the transport of RNA and proteins through the nuclear pore complex. Together, Ran BP-M and TWA1 form a complex with cytoplasmic Muskelin, a mediator of cell spreading. It is thought that this complex plays a role in the Ran GTPase cycle and therefore a potential role in the cell cycle. TWA1 contains a LisH-CTLH motif which is usually found in proteins that are involved in nucleokinesis, chromosome segregation, cell migration and microtubule dynamics. The gene encoding TWA1 maps to human chromosome 20, which comprises approximately 2% of the human genome and contains nearly 63 million bases that encode over 600 genes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11625R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11625R-A680
Lokale Artikelnummer::
BOSSBS-11625R-A680
Beschreibung:
WW domain-binding protein 2 (WBP2) is a 261 amino acid protein expressed in most tissues. The WW domain is composed of 38 to 40 semi-conserved amino acids and is shared by various groups of proteins, including structural, regulatory and Signalling proteins. The domain mediates protein-protein interactions through the binding of polyproline ligands. WBP2 binds to the WW domain of Yes-associated protein (YAP), WW domain containing E3 ubiquitin protein ligase 1 (AIP5) and WW domain containing E3 ubiquitin protein ligase 2 (AIP2). The gene encoding WBP2 is located on human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes, some of which are involved in tumour suppression and in the pathogenesis of Li-Fraumeni syndrome, early onset breast cancer and a predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12210R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12210R-A488
Lokale Artikelnummer::
BOSSBS-12210R-A488
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF81, also known as HFZ20 or MRX45, is a transcriptional regulator belonging to the Krüppel C2H2-type zinc-finger protein family. It localizes to the nucleus and contains 12 C2H2-type zinc fingers and 1 KRAB domain. Mutations in the gene encoding ZNF81 are implicated in nonsyndromic X-linked mental retardation (XLMR).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1080R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1080R
Lokale Artikelnummer::
BOSSBS-1080R
Beschreibung:
Anti-SOD2 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2518R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2518R-CY5.5
Lokale Artikelnummer::
BOSSBS-2518R-CY5.5
Beschreibung:
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5626R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5626R-A350
Lokale Artikelnummer::
BOSSBS-5626R-A350
Beschreibung:
The synucleins, including Alpha-synuclein (also designated NACP for nonamyloid component precursor),Beta-synuclein (also designated PNP 14 for neuroprotein 14)and Gamma-synuclein (also designated persyn or BCSG1 for breast cancer-specific gene 1)are presynaptic protein abundant in neurons. Alpha-synuclein, a component of Alzheimer’s disease amyloid plaques, is localized to neuronal cell bodies and synapses. Coordinate expression of Alpha-synucleinand Beta-synuclein may be important during hematopoetic cell differentiation. In patients with Parkinson’s disease, a mutant form of Alpha-synuclein has been found and Gamma-synuclein is associated with axonal pathology.
VE:
1 * 100 µl
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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