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Benzoic+acid-acyl-\\u03B2-D-glucuronide
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Benzoic+acid-acyl-\\u03B2-D-glucuronide
Artikel-Nr:
(BOSSBS-3160R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3160R-CY5
Lokale Artikelnummer::
BOSSBS-3160R-CY5
Beschreibung:
Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3160R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3160R-HRP
Lokale Artikelnummer::
BOSSBS-3160R-HRP
Beschreibung:
Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3160R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3160R-A555
Lokale Artikelnummer::
BOSSBS-3160R-A555
Beschreibung:
Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL.
VE:
1 * 100 µl
Artikel-Nr:
(BLDPBD760173-100MG)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD760173-100MG
Lokale Artikelnummer::
BLDPBD760173-100MG
Beschreibung:
2-(2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulphonate 97%
VE:
1 * 100 mg
Artikel-Nr:
(APOSOR32438-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR32438-1G
Lokale Artikelnummer::
APOSOR32438-1G
Beschreibung:
Ethyl 2-[(3E)-2-oxo-1-(prop-2-en-1-yl)-2,3-dihydro-1H-indol-3-ylidene]acetate, tech
VE:
1 * 1 g
Artikel-Nr:
(9280-R)
Lieferant:
Avantor
Lokale Artikelnummer::
BAKR9280-R
Beschreibung:
The quality of many BAKER ANALYZED™ Reagents meets or exceeds the requirements set forth by the American Chemical Society (ACS). These solvents are essential for any chemical stockroom.
VE:
1 * 400 lb
Artikel-Nr:
(124312W)
Lieferant:
VWR Chemicals
Lokale Artikelnummer::
VWRC124312W
Beschreibung:
Organic Standard, Malathion (1,2-Bis(ethoxycarbonyl)ethyl-O,O-dimethyldithiophosphat) 100 µg/ml in Methanol, Packung: Glasampulle
VE:
1 * 1 mL
Artikel-Nr:
(APOSPC410294-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC410294-1G
Lokale Artikelnummer::
APOSPC410294-1G
Beschreibung:
{[4-(1-Ethyl-3-methyl-1H-pyrazol-4-yl)-6-(trifluoromethyl)pyrimidin-2-yl]sulphanyl}acetic acid
VE:
1 * 1 g
Artikel-Nr:
(93003.1006)
Lieferant:
VWR Chemicals
Lokale Artikelnummer::
VWRC93003.1006
Beschreibung:
Ethanol ≥70% (v/v)
VE:
1 * 6 L
Artikel-Nr:
(BLDPBD14063-5G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD14063-5G
Lokale Artikelnummer::
BLDPBD14063-5G
Beschreibung:
2-((2-Acetamido-6-oxo-1H-purin-9(6H)-yl)methoxy)ethyl acetate 97%
VE:
1 * 5 g
Artikel-Nr:
(APOSPC450033-250MG)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC450033-250MG
Lokale Artikelnummer::
APOSPC450033-250MG
Beschreibung:
[(1R)-1-(3,5-Bis(Trifluoromethyl)phenyl)ethyl][(1S)-1-phenylethyl]ammonium fumarate
VE:
1 * 250 mg
Artikel-Nr:
(BLDPBD247544-5G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD247544-5G
Lokale Artikelnummer::
BLDPBD247544-5G
Beschreibung:
Ethyl 6-(4-aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 95%
VE:
1 * 5 g
Artikel-Nr:
(BOSSBS-0802R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0802R-A555
Lokale Artikelnummer::
BOSSBS-0802R-A555
Beschreibung:
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0802R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0802R-A647
Lokale Artikelnummer::
BOSSBS-0802R-A647
Beschreibung:
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8.
VE:
1 * 100 µl
Artikel-Nr:
(APOSOR111281-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR111281-1G
Lokale Artikelnummer::
APOSOR111281-1G
Beschreibung:
Ethyl [4-(5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)phenyl]acetate
VE:
1 * 1 g
Artikel-Nr:
(BOSSBS-3504R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3504R-FITC
Lokale Artikelnummer::
BOSSBS-3504R-FITC
Beschreibung:
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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