Sie suchten nach: ligase

Artikel-Nr: (BOSSBS-6757R-CY5.5)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-6757R-CY5.5

Lokale Artikelnummer:: BOSSBS-6757R-CY5.5

Beschreibung: The RING finger family of proteins possess ubiquitin ligase activity and play pivotal roles in protein degradation and receptor-mediated endocytosis. The autoubiquitination activity of ZNF364 indicates that it is a novel RING-type E3 ligase. Its effects on cell growth indicate that ZNF364 may be important for the ubiquitin modification of proteins crucial to breast carcinogenesis and growth.

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Artikel-Nr: (BOSSBS-9382R-CY7)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9382R-CY7

Lokale Artikelnummer:: BOSSBS-9382R-CY7

Beschreibung: Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.

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Artikel-Nr: (BOSSBS-4291R-CY5)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-4291R-CY5

Lokale Artikelnummer:: BOSSBS-4291R-CY5

Beschreibung: Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.

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Artikel-Nr: (BOSSBS-9339R-CY5)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9339R-CY5

Lokale Artikelnummer:: BOSSBS-9339R-CY5

Beschreibung: MARCH5 is a member of the E3 ubiquitin-protein ligase family. This mitochonrial E3 ubiquitin-protein ligase plays an importnat role in controlling the morphology of the mitochondria. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. MARCH5 has been shown to interact with MTFN2 and ubiquitinated forms of DRP1.

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Artikel-Nr: (BOSSBS-9339R-CY5.5)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9339R-CY5.5

Lokale Artikelnummer:: BOSSBS-9339R-CY5.5

Beschreibung: MARCH5 is a member of the E3 ubiquitin-protein ligase family. This mitochonrial E3 ubiquitin-protein ligase plays an importnat role in controlling the morphology of the mitochondria. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. MARCH5 has been shown to interact with MTFN2 and ubiquitinated forms of DRP1.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-6107R-A647)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-6107R-A647

Lokale Artikelnummer:: BOSSBS-6107R-A647

Beschreibung: Has both helicasee and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-6107R-HRP)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-6107R-HRP

Lokale Artikelnummer:: BOSSBS-6107R-HRP

Beschreibung: Has both helicasee and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9119R-FITC)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9119R-FITC

Lokale Artikelnummer:: BOSSBS-9119R-FITC

Beschreibung: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].

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Artikel-Nr: (BOSSBS-9628R-CY7)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9628R-CY7

Lokale Artikelnummer:: BOSSBS-9628R-CY7

Beschreibung: C16orf44 is a 616 amino acid protein that contains six Kelch repeats, one BTB/POZ domain and one BTB/Kelch associated (BACK) domain. C16orf44 is believed to play a role in protein ubiquitination and may function as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, C16orf44 interacts with CUL-3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin-mediated proteolysis. Due to alternative splicing events, two isoforms of C16orf44 are expressed.

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Artikel-Nr: (BOSSBS-9120R-CY5.5)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9120R-CY5.5

Lokale Artikelnummer:: BOSSBS-9120R-CY5.5

Beschreibung: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity.

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Artikel-Nr: (BOSSBS-3634R-CY5)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-3634R-CY5

Lokale Artikelnummer:: BOSSBS-3634R-CY5

Beschreibung: Siah2 is a E3 Ubiquitin ligase protein that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targets. Siah2 triggers the ubiquitin-mediated degradation of many proteins, including transcription regulators (e.g. POU2AF1, PML, NCOR1), cell surface receptors (e.g. DCC), antiapoptotic proteins (e.g. BAG1), and proteins involved in synaptic vesicle function in neurons (e.g. SYP). Siah2 has some overlapping function with SIAH1 but is able to trigger the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not.

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Artikel-Nr: (BOSSBS-11383R)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-11383R

Lokale Artikelnummer:: BOSSBS-11383R

Beschreibung: ACSF1 is a 672 amino acid protein belonging to the ATP-dependent AMP-binding enzyme family. Encoded by a gene that maps to human chromosome 12q24.31, ACSF1 is highly expressed in kidney, heart and brain, and shows similar neural expression as HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). Existing as three alternatively spliced isoforms, ACSF1 participates in ATP binding, ligase activity, acetoacetate-CoA ligase activity and nucleotide binding. The ACSF1 promoter is a known PPAR?target gene, with the nuclear receptor recruited to the ACSF1 promoter by direct interaction with stimulating protein-1 (Sp1). ACSF1 activates acetoacetate and is highly regulated by modulators that affect HMGCR and cholesterol biosynthesis.

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Artikel-Nr: (BOSSBS-11383R-CY7)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-11383R-CY7

Lokale Artikelnummer:: BOSSBS-11383R-CY7

Beschreibung: ACSF1 is a 672 amino acid protein belonging to the ATP-dependent AMP-binding enzyme family. Encoded by a gene that maps to human chromosome 12q24.31, ACSF1 is highly expressed in kidney, heart and brain, and shows similar neural expression as HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). Existing as three alternatively spliced isoforms, ACSF1 participates in ATP binding, ligase activity, acetoacetate-CoA ligase activity and nucleotide binding. The ACSF1 promoter is a known PPAR?target gene, with the nuclear receptor recruited to the ACSF1 promoter by direct interaction with stimulating protein-1 (Sp1). ACSF1 activates acetoacetate and is highly regulated by modulators that affect HMGCR and cholesterol biosynthesis.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9123R-CY5.5)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9123R-CY5.5

Lokale Artikelnummer:: BOSSBS-9123R-CY5.5

Beschreibung: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9123R-CY5)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9123R-CY5

Lokale Artikelnummer:: BOSSBS-9123R-CY5

Beschreibung: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-23085R-A750)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-23085R-A750

Lokale Artikelnummer:: BOSSBS-23085R-A750

Beschreibung: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

VE: 1 * 100 µl

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