Suche >
ligase
Drucken
Sie suchten nach:
5 413 results were found
ligase
Artikel-Nr:
(BOSSBS-3596R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3596R-A488
Lokale Artikelnummer::
BOSSBS-3596R-A488
Beschreibung:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Confers constitutive instability to HIPK2 through proteasomal degradation. It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling. Has some overlapping function with SIAH2. Induces apoptosis in cooperation with PEG3. Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus. GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8367R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8367R-CY5
Lokale Artikelnummer::
BOSSBS-8367R-CY5
Beschreibung:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8367R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8367R-CY7
Lokale Artikelnummer::
BOSSBS-8367R-CY7
Beschreibung:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9132R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9132R-CY5.5
Lokale Artikelnummer::
BOSSBS-9132R-CY5.5
Beschreibung:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11625R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11625R
Lokale Artikelnummer::
BOSSBS-11625R
Beschreibung:
WW domain-binding protein 2 (WBP2) is a 261 amino acid protein expressed in most tissues. The WW domain is composed of 38 to 40 semi-conserved amino acids and is shared by various groups of proteins, including structural, regulatory and signaling proteins. The domain mediates protein-protein interactions through the binding of polyproline ligands. WBP2 binds to the WW domain of Yes-associated protein (YAP), WW domain containing E3 ubiquitin protein ligase 1 (AIP5) and WW domain containing E3 ubiquitin protein ligase 2 (AIP2). The gene encoding WBP2 is located on human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes, some of which are involved in tumor suppression and in the pathogenesis of Li-Fraumeni syndrome, early onset breast cancer and a predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5470R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5470R-CY7
Lokale Artikelnummer::
BOSSBS-5470R-CY7
Beschreibung:
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11625R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11625R-CY5
Lokale Artikelnummer::
BOSSBS-11625R-CY5
Beschreibung:
WW domain-binding protein 2 (WBP2) is a 261 amino acid protein expressed in most tissues. The WW domain is composed of 38 to 40 semi-conserved amino acids and is shared by various groups of proteins, including structural, regulatory and signaling proteins. The domain mediates protein-protein interactions through the binding of polyproline ligands. WBP2 binds to the WW domain of Yes-associated protein (YAP), WW domain containing E3 ubiquitin protein ligase 1 (AIP5) and WW domain containing E3 ubiquitin protein ligase 2 (AIP2). The gene encoding WBP2 is located on human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes, some of which are involved in tumor suppression and in the pathogenesis of Li-Fraumeni syndrome, early onset breast cancer and a predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5471R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5471R-FITC
Lokale Artikelnummer::
BOSSBS-5471R-FITC
Beschreibung:
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6916R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6916R
Lokale Artikelnummer::
BOSSBS-6916R
Beschreibung:
Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7544R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7544R
Lokale Artikelnummer::
BOSSBS-7544R
Beschreibung:
Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4090R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4090R-A680
Lokale Artikelnummer::
BOSSBS-4090R-A680
Beschreibung:
This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9343R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9343R-CY5
Lokale Artikelnummer::
BOSSBS-9343R-CY5
Beschreibung:
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). MARCH9 (membrane-associated ring finger (C3HC4) 9), also known as RNF179, is a 346 amino acid multi-pass membrane protein that localizes to the golgi apparatus and contains one RING-CH-type zinc finger. Expressed ubiquitously, MARCH9 exists as a homodimer and functions as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and is thought to promote the degradation of target proteins, such as CD4 and MHC-I. Multiple isoforms of MARCH9 exist due to alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6916R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6916R-CY5
Lokale Artikelnummer::
BOSSBS-6916R-CY5
Beschreibung:
Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6916R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6916R-A750
Lokale Artikelnummer::
BOSSBS-6916R-A750
Beschreibung:
Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6389R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6389R-A488
Lokale Artikelnummer::
BOSSBS-6389R-A488
Beschreibung:
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of PCNP. May participate in methylation-dependent transcriptional regulation. Important for G1/S transition. Overexpression causes G1 phase cell arrest.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5174R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5174R-CY5.5
Lokale Artikelnummer::
BOSSBS-5174R-CY5.5
Beschreibung:
This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011].
VE:
1 * 100 µl
Preis auf Anfrage
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
Dieses Produkt wurde von Ihrer Organisation gesperrt. Bitte kontaktieren Sie Ihren Einkauf für weitere Informationen.
Dieses Produkt ist Ersatz für den von Ihnen gewünschten Artikel.
Dieses Produkt ist nicht mehr verfügbar. Bitte kontaktieren Sie den VWR Kundenservice.
|
|||||||||
Listenansicht
