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BIOSS INC
Artikel-Nr:
(BOSSBS-4031R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4031R
Lokale Artikelnummer::
BOSSBS-4031R
Beschreibung:
Slc9a9 (Sodium/hydrogen exchanger 9) or NHE9 may act in electroneutral exchange of protons for Na(+) across membranes. Four isoforms of the Na+/H+ exchanger (NHE6-NHE9) are distributed to intracellular compartments in human cells. They are localized to Golgi and post-Golgi endocytic compartments as follows: mid- to trans-Golgi, NHE8; trans-Golgi network, NHE7; early recycling endosomes, NHE6; and late recycling endosomes, NHE9. The intracellular localization of the NHEs is established by the balance of transport in and out of the post-Golgi compartments as the dynamic membrane trafficking. Their in vivo function is to regulate the pH and monovalent cation concentration in these organelles.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3270R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3270R-HRP
Lokale Artikelnummer::
BOSSBS-3270R-HRP
Beschreibung:
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4962R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4962R-CY5
Lokale Artikelnummer::
BOSSBS-4962R-CY5
Beschreibung:
Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0051R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0051R-HRP
Lokale Artikelnummer::
BOSSBS-0051R-HRP
Beschreibung:
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13092R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13092R-A350
Lokale Artikelnummer::
BOSSBS-13092R-A350
Beschreibung:
ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. Isoform 2 lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized. Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2); also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0116R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0116R-A350
Lokale Artikelnummer::
BOSSBS-0116R-A350
Beschreibung:
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2454R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2454R-A750
Lokale Artikelnummer::
BOSSBS-2454R-A750
Beschreibung:
Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6164R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6164R-CY3
Lokale Artikelnummer::
BOSSBS-6164R-CY3
Beschreibung:
Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5304R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5304R-HRP
Lokale Artikelnummer::
BOSSBS-5304R-HRP
Beschreibung:
Separase is a cysteine protease that is essential for mitotic progression by separating sister chromatids. Each cell must receive one chromatid of every chromosome, during mitosis. Cohesin plays an important role in cohering sister chromatids during the prophase through anaphase stages of mitosis, making certain that genomic information is replicated accurately. As the cellular division process continues, separase destroys cohesin by means of cleavage, allowing the chromatids to separate and divide with the cell. Separase activity is highly regulated. It not only cleaves cohesin at the onset of anaphase but also cleaves itself, promoting downregulation of separase after anaphase. Should a human cell become an aneuploid (one too many or too few chromatids), the embryo most likely will not survive. Should the embryo survive, it will most likely develop severe birth defects or later develop malignant cancers.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11034R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11034R-A750
Lokale Artikelnummer::
BOSSBS-11034R-A750
Beschreibung:
MYBPC1 is a 1141 amino acid protein that contains three fibronectin type-III domains and seven Ig-like C2-type domains. Existing as a member of the immunoglobulin superfamily, MYBPC1 functions as a thick filament-associated protein that localizes to striated muscle bands in vertebrae and is thought to modify the activity of select ATPases. Additionally, MYBPC1 may play a role in the modulation of muscle contraction and in the overall structural integrity of the cell. The gene encoding MYBPC1 maps to human chromosome 12, which encodes over 1100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and Trisomy 12p, which causes facial developmental defects and seizure disorders.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11197R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11197R-A680
Lokale Artikelnummer::
BOSSBS-11197R-A680
Beschreibung:
May function as an adhesion molecule involved in stabilisation and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11791R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11791R-A680
Lokale Artikelnummer::
BOSSBS-11791R-A680
Beschreibung:
G protein-coupled receptors (GPRs or GPCRs), are members of the largest protein family and play a role in many different stimulus-response pathways. G-protein coupled receptors mediate extracellular signals into intracellular signals (G-protein activation). They respond to a great variety of Signalling molecules, including hormones, neurotransmitters and other proteins and peptides. GPR143, also designated ocular albinism type 1 protein (OA1), is detected exclusively in pigment cells. OA1, which is a multi-pass membrane protein, is a melanosomal protein expressed primarily in pigment cells. Defects in the gene encoding for OA1 cause ocular albinism, an X-linked disorder mainly characterised by retinal hypopigmentation and visual impairment.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7953R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7953R-A680
Lokale Artikelnummer::
BOSSBS-7953R-A680
Beschreibung:
Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0099R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0099R-CY3
Lokale Artikelnummer::
BOSSBS-0099R-CY3
Beschreibung:
Involved in embryogenesis and cell differentiation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2940R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2940R-CY7
Lokale Artikelnummer::
BOSSBS-2940R-CY7
Beschreibung:
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6869R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6869R-A350
Lokale Artikelnummer::
BOSSBS-6869R-A350
Beschreibung:
HBXIP (Hepatitis B virus X interacting protein) complexes with the C-terminus of hepatitis B virus X protein (HBx) and down-regulates hepatitis B virus (HBV) replication. When complexed to BIRC5, it interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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