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BIOSS INC
Artikel-Nr:
(BOSSBS-5541R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5541R-HRP
Lokale Artikelnummer::
BOSSBS-5541R-HRP
Beschreibung:
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity. [SUBCELLULAR LOCATION] Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Constituent of focal adhesions.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11943R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11943R-FITC
Lokale Artikelnummer::
BOSSBS-11943R-FITC
Beschreibung:
May activate transcription by interacting directly with the X-box.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7728R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7728R-CY5.5
Lokale Artikelnummer::
BOSSBS-7728R-CY5.5
Beschreibung:
SMC4 is a central component of the condensin complex, which is required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6472R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6472R-CY3
Lokale Artikelnummer::
BOSSBS-6472R-CY3
Beschreibung:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0591R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0591R-CY5
Lokale Artikelnummer::
BOSSBS-0591R-CY5
Beschreibung:
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0416R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0416R-CY5
Lokale Artikelnummer::
BOSSBS-0416R-CY5
Beschreibung:
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-1, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5124R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5124R-CY7
Lokale Artikelnummer::
BOSSBS-5124R-CY7
Beschreibung:
HSPC300 (hematopoietic stem cell protein 300) is also known as probable protein BRICK1 or C3orf10 (chromosome 3 open reading frame 10) and is a 75 amino acid protein that is expressed as two isoforms and localizes to both the cytoplasm and the cytoskeleton. HSPC300 is thought to regulate cytoskeletal organization and Actin polymerization. Free HSPC300 exists as homotrimers prior to its incorporation into the WAVE complex. The WAVE complex includes five proteins, one of which is HSPC300, that regulate the ARC (Arp2/3 complex) which is responsible for Actin nucleation and is Rac 1-dependent. Because HSPC300 is a highly conserved subunit of the WAVE complex across many species, it is thought to have the same or similar functions in many different organisms. In Drosophila, the WAVE/ARC pathway may affect the development of the nervous system. HSPC300 is thought to localize to axons of the central nervous system of Drosophila embryos and thus may also be involved in axonogenesis. In addition, HSPC300 is thought to be necessary for synaptic morphogenesis by motoneurons. In mice, the knockout of the WAVE complex leads to learning and memory defects, and it is therefore hypothesized that HSPC300 may also be involved in cognitive functions. Genetic depletion of HSPC300 results in cytoskeletal abnormalities and prevents cytokinesis of cells, suggesting that decreased levels of HSPC300 may be associated with tumor suppression.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13505R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13505R-CY7
Lokale Artikelnummer::
BOSSBS-13505R-CY7
Beschreibung:
GPCR2037 is a G protein-coupled receptor that undergoes weak activation by Galanin and is most abundant in the central nervous system (CNS), where it appears to be critical for development. During embryonal development the expression of GPCR2037 is widespread in the nervous system (dorsal thalamus, striatum, locus coeruleus and hindbrain nuclei). GPCR2037 in the CNS of 7- and 15-day-old mouse embryos can localize to the habenular complex. Low levels of GPCR2037 are detectable in testis, liver, kidney and stomach. In addition to GPCR2037, Galanin mediates its effects through receptor subtypes GALR1, 2 and 3. Galanin ligand exerts anxiolytic actions via GALR receptors under conditions of high stress. Galanin coexists with norepinephrine and serotonin in neural systems that mediate emotion.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12869R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12869R-A555
Lokale Artikelnummer::
BOSSBS-12869R-A555
Beschreibung:
BIVM (for basic, immunoglobulin like variable motif containing) refers to a recently identified gene product that maps to human chromosome 13q32-q33 and is predicted to encode a 503 amino acid protein. BIVM shows ubiquitous expression in normal human tissue and the presence of a 5' CpG island suggests it is a housekeeping gene. BIVM is likely essential for some aspect of basic cellular function. BIVM is highly charged and localizes to the cytoplasm and nucleus where it may bind to either DNA or RNA or associate with other cellular proteins. Significant sequence homology exists with many organisms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13046R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13046R-A647
Lokale Artikelnummer::
BOSSBS-13046R-A647
Beschreibung:
Excitatory Amino Acid Transporters (EAATs) are membrane-bound proteins that are localized in glial cells and pre-synaptic glutamatergic nerve endings. EAATs transport the excitatory neurotransmitters L-glutamate and D-aspartate, a process that is essential for terminating the postsynaptic action of glutamate. The re-uptake of amino acid neurotransmitters by EAAT proteins has been shown to protect neurons from excitotoxicity, which is caused by the accumulation of amino acid neurotransmitters. EAAT4 is an aspartate/glutamate transporter that is expressed predominantly in the cerebellum. The transport activity encoded by EAAT4 has high apparent affinity for L-aspartate and L-glutamate, and has a pharmacologic profile consistent with previously described cerebellar transport activities. EAAT5 is a glutamate transporter coupled to a chloride conductance which is expressed primarily in retina. Although EAAT5 shares the structural homologies of the EAAT family, a novel feature of the EAAT5 sequence is a carboxy-terminal motif previously identified in N-ethyl-D-aspartate receptors and potassium channels and shown to confer interactions with a family of synaptic proteins that promote ion channel clustering.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2277R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2277R-CY5
Lokale Artikelnummer::
BOSSBS-2277R-CY5
Beschreibung:
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10446R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10446R-HRP
Lokale Artikelnummer::
BOSSBS-10446R-HRP
Beschreibung:
Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11275R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11275R-A647
Lokale Artikelnummer::
BOSSBS-11275R-A647
Beschreibung:
CtBP1 associates in complexes with histone deacetylases (HDAC), the G9a histone methyltransferase, and LSD1 histone demethylase illustrating its role in transcriptional repression. Through its association with centrosomes, CtBP1 appears to also play a role in mitosis and Golgi complex organization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11262R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11262R-A488
Lokale Artikelnummer::
BOSSBS-11262R-A488
Beschreibung:
MP21 is a member of the EMP24/GP25L/p24 cargo family of proteins that regulates vesicular trafficking in the early secretory pathway. TMP21 is a ubiquitously expressed single-pass type I membrane protein localizing to the Golgi cisternae and the plasma membrane. It contains one GOLD (Golgi dynamics) domain and participates in protein transport and quality control between the endoplasmic reticulum (ER) and the Golgi complex. In addition, TMP21 is a component of the heteromeric secretase complex (or Presenilin complex) and functions to regulate the ?secretase activity. Two isoforms, namely TMP21-I and TMP21-II, exist for this protein.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0538R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0538R-HRP
Lokale Artikelnummer::
BOSSBS-0538R-HRP
Beschreibung:
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2363R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2363R-CY5
Lokale Artikelnummer::
BOSSBS-2363R-CY5
Beschreibung:
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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