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BIOSS INC
Artikel-Nr:
(BOSSBS-6818R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6818R-A488
Lokale Artikelnummer::
BOSSBS-6818R-A488
Beschreibung:
Not known, though may play a role in tumor transformation or aspects of tumor progression.Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6279R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6279R-A555
Lokale Artikelnummer::
BOSSBS-6279R-A555
Beschreibung:
Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5711R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5711R-A555
Lokale Artikelnummer::
BOSSBS-5711R-A555
Beschreibung:
Promotes the degradation of p53/TP53 protein and inhibits its transactivity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0274R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0274R-CY5.5
Lokale Artikelnummer::
BOSSBS-0274R-CY5.5
Beschreibung:
C Peptide is part of the molecule of Proinsulin, that consists of three parts: C Peptide and two long strands of amino acids (called the alpha and beta chains) that later become linked together to form the insulin molecule. From every molecule of proinsulin, one molecule of insulin plus one molecule of C Peptide are produced. C peptide is released into the blood stream in equal amounts to insulin. A test of C peptide levels will show how much insulin the body is making. Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12181R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12181R-CY3
Lokale Artikelnummer::
BOSSBS-12181R-CY3
Beschreibung:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3532R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3532R-A350
Lokale Artikelnummer::
BOSSBS-3532R-A350
Beschreibung:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3425R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3425R-CY3
Lokale Artikelnummer::
BOSSBS-3425R-CY3
Beschreibung:
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2955R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2955R-CY3
Lokale Artikelnummer::
BOSSBS-2955R-CY3
Beschreibung:
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7696R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7696R-FITC
Lokale Artikelnummer::
BOSSBS-7696R-FITC
Beschreibung:
This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4285R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4285R-A350
Lokale Artikelnummer::
BOSSBS-4285R-A350
Beschreibung:
TPX2 is essential for spindle pole and mitotic spindle formulation, playing a role in the S and G2 phases of mitosis. It is also critical for the function of protein kinase Aurora A. TPX2 autophosphorylates Aurora A, targeting it to the spindle apparatus and allowing it to function in eukaryotic meiotic and mitotic cell cycles. TPX2 has also been found to be highly expressed in cancer cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4538R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4538R-A488
Lokale Artikelnummer::
BOSSBS-4538R-A488
Beschreibung:
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6991R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6991R-CY5.5
Lokale Artikelnummer::
BOSSBS-6991R-CY5.5
Beschreibung:
In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signaling between transcriptional activators and initiation factors. These complexes include the thyroid hormone receptor-associated protein (TRAP) complex, which interacts with thyroid receptors (TR), vitamin D receptors and other steroid receptors to facilitate hormone induced transcriptional activation. The TRAP complex consists of numerous proteins ranging in size including TRAP95, TRAP100, TRAP150, TRAP220 and TRAP230, that are characterized by the presence of a nuclear receptor recognition motif which mediates the ligand-dependent binding of TRAP proteins to the nuclear receptors. TRAP220 and TRAP100 are widely expressed and most abundantly detected in skeletal muscle, heart and placenta. TRAP95, TRAP150 and TRAP230 facilitate TR induced transcription by associating with an additional transcriptional coactivating complex SMCC (SRB and MED protein cofactor complex), which consists of various subunits that share homology with several components of the yeast transcriptional mediator complexes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8596R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8596R-A488
Lokale Artikelnummer::
BOSSBS-8596R-A488
Beschreibung:
GPR120, a member of the rhodopsin family of G protein-coupled receptors (GPCRs), is a 377 amino acid protein which is expressed in the intestine. GPR120 is a receptor for unsaturated long-chain FFAs (free fatty acids). FFAs act as signaling molecules and are an important energy source. They also employ various physiological responses through their GPCRs. One such response occurs when dietary FFAs stimulate GPR120. This stimulation promotes the secretion of glucagon-like peptide 1 (GLP-1) in vivo and in vitro. GLP-1 belongs to the class of molecules known as the incretins, which are associated with insulin secreted from the pancreas as a result of food intake. GLP-1 also inhibits glucagon and gastric acid secretion and gastric emptying. Consequently, the role of GPR120 in the secretion of GLP-1 is critical in the treatment of diabetes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9741R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9741R-A488
Lokale Artikelnummer::
BOSSBS-9741R-A488
Beschreibung:
ANGEL1 , also known as KIAA0759, is a 670 amino acid protein belonging to the CKR-4 protein family. ANGEL1 is encoded by a gene located on human chromosome 14, which contains about 700 genes and 106 million base pairs, making up about 3.5% of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and, when defective, leads to the genetic disorder ?-antitrypsin deficiency. This disorder is characterized by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus on chromosome 14 and its fusion via translocation with the chromosome 19 encoded protein BCL3 may be related to B-cell malignancies.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9487R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9487R-FITC
Lokale Artikelnummer::
BOSSBS-9487R-FITC
Beschreibung:
LACE1 is a 481 amino acid protein that belongs to the AFG1 ATPase family. LACE1 is encoded by a gene mapping to human chromosome 6. Making up nearly 6% of the human genome, chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0814R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0814R-A750
Lokale Artikelnummer::
BOSSBS-0814R-A750
Beschreibung:
Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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