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BIOSS INC
Artikel-Nr:
(BOSSBS-7913R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7913R-FITC
Lokale Artikelnummer::
BOSSBS-7913R-FITC
Beschreibung:
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7781R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7781R-CY3
Lokale Artikelnummer::
BOSSBS-7781R-CY3
Beschreibung:
Required for S phase entry of the cell cycle.The eukaryotic cell division cycle consists of a number of gene-controlled sequences that involve cyclin dependent kinases (Cdks) and cell division control (Cdc) proteins. Cdc123 (Cell division cycle protein 123), also known as D123, is a 336 amino acid cytoplasmic protein that is involved in cell cycle control. Widely expressed with high expression in thymus, spleen, ovary, testis, small intestine and leukocytes, Cdc123 functions to destabilize Chfr (checkpoint with forkhead and ring finger domain) proteins which, when accumulated, block the G to S phase transition. Cdc123 prevents the Chfr proteins from collecting in the cell, thereby allowing the cell to enter the S phase. Due to its role in cell cycle control, Cdc123 is thought to be a basal marker for luminal breast cancers.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9634R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9634R-A647
Lokale Artikelnummer::
BOSSBS-9634R-A647
Beschreibung:
The Isocitrate dehydrogenase cytoplasmic enzyme is a homodimer of 416 residues that belongs to the isocitrate and isopropylmalate dehydrogenases family. IDHC catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming ?ketoglutarate and CO2 in a two step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of ?ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Ca2+ can bind to IDHC as a complex with isocitrate, acting as a competitive inhibitor of Mg2+. The IDHC enzyme is inactivated by phosphorylation at Ser-113 and contains a clasp-like domain wherein both polypeptide chains in the dimer interlock. IDHC is expressed in a wide range of species and also in organisms that lack a complete citric acid cycle.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11318R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11318R-CY3
Lokale Artikelnummer::
BOSSBS-11318R-CY3
Beschreibung:
The human ataxin-7 gene, also known as spinocerebellar ataxia 7 or SCA7, maps to chromosome 3p13-p12, has a 2,727-bp open reading frame, and encodes a 892 amino acid protein containing a nuclear localization signal and a polyglutamine tract (1,2). SCA7 is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss caused by the expansion of a translated CAG repeat encoding a polyglutamine tract in ataxin-7, which is the SCA7 gene product (3,4). Ataxin-7 is expressed within neurons both affected and unaffected in SCA7 pathology with subcellular localization being variable depending upon the neuronal subtype (5). Polyglutamine expanded in ataxin-7 may carry out its pathogenic effects in the nucleus by altering the matrix-associated nuclear structure and/or by disrupting nucleolar function (6).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6279R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6279R-CY3
Lokale Artikelnummer::
BOSSBS-6279R-CY3
Beschreibung:
Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3452R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3452R-HRP
Lokale Artikelnummer::
BOSSBS-3452R-HRP
Beschreibung:
Rb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F1, PU1, ATF2, UBF, Elf1 and cAbl. This ability of Rb to alter transcription is regulated by phosphorylation catalyzed by the cyclin dependent protein kinases (cdks). Rb is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus 16E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4035R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4035R
Lokale Artikelnummer::
BOSSBS-4035R
Beschreibung:
The SENP3 protease releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. It deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7830R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7830R
Lokale Artikelnummer::
BOSSBS-7830R
Beschreibung:
Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1014R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1014R-A680
Lokale Artikelnummer::
BOSSBS-1014R-A680
Beschreibung:
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognises the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognises P1 and P2 peptides of fibrinogen gamma chain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0043R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0043R-A750
Lokale Artikelnummer::
BOSSBS-0043R-A750
Beschreibung:
Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0182R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0182R-A750
Lokale Artikelnummer::
BOSSBS-0182R-A750
Beschreibung:
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4957R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4957R-A680
Lokale Artikelnummer::
BOSSBS-4957R-A680
Beschreibung:
Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5331R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5331R-A680
Lokale Artikelnummer::
BOSSBS-5331R-A680
Beschreibung:
mTOR is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 289-kDa protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1389R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1389R-CY5.5
Lokale Artikelnummer::
BOSSBS-1389R-CY5.5
Beschreibung:
May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-23026R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-23026R-A750
Lokale Artikelnummer::
BOSSBS-23026R-A750
Beschreibung:
Receptor for the CCL2, CCL7 and CCL12 chemokines. Transduces a signal by increasing intracellular calcium ion levels.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-14099R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-14099R-A680
Lokale Artikelnummer::
BOSSBS-14099R-A680
Beschreibung:
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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