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BIOSS INC
Artikel-Nr:
(BOSSBS-7103R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7103R-A350
Lokale Artikelnummer::
BOSSBS-7103R-A350
Beschreibung:
THAP1 contains a THAP domain, a zinc-dependent DNA-binding domain. It colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies and is a pro-apoptopic protein that potentiates both serum-withdrawal and TNF-induced apoptosis. It is a physiologic regulator of endothelial cell proliferation and cell-cycle progression, two essential processes for angiogenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13349R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13349R
Lokale Artikelnummer::
BOSSBS-13349R
Beschreibung:
g-glutamyltranspeptidase (GGT) acts as a glutathionase and catalyzes the transfer of the glutamyl moiety of Glutathione to a variety of amino acids and dipeptide acceptors. This enzyme is located on the outer surface of the cell membrane and is widely distributed in mammalian tissues involved in absorption and secretion. In humans, hepatic GGT activity is elevated in some liver diseases. GGT1 is released into the bloodstream after liver damage and an elevated level of the enzyme may be a useful early sign of hepatocellular carcinoma. GGT5 converts Leukotriene C4 to Leukotriene D4; it does not, however, convert synthetic substrates that are commonly used to assay GGT. In human serum and tissues there is a marked heterogeneity in GGT, but this heterogeneity can be attributed to different glycosylation of the same peptide rather than to the products of different genes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1738R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1738R-CY3
Lokale Artikelnummer::
BOSSBS-1738R-CY3
Beschreibung:
c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13712R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13712R-CY3
Lokale Artikelnummer::
BOSSBS-13712R-CY3
Beschreibung:
Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9388R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9388R-A555
Lokale Artikelnummer::
BOSSBS-9388R-A555
Beschreibung:
The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription as well as mRNA degradation. Various subunits within the complex are involved in influencing nuclear hormone receptor activities. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome. CNOT8 (CCR4-NOT transcription complex subunit 8), also known as CALIF or POP2, is a 292 amino acid protein that localizes to both the nucleus and the cytoplasm and functions as part of the CCR-NOT complex. Expressed ubiquitously, CNOT8 plays a role in transcriptional regulation for a diverse set of processes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11592R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11592R-A555
Lokale Artikelnummer::
BOSSBS-11592R-A555
Beschreibung:
Acetyltransferases and deacetylases are protein groups most often associated with oncogenesis and cell cycle regulation. NAT-8B (N-acetyltransferase 8B), also known as CML2 (camello-like protein 2), is a 227 amino acid single-pass membrane protein that is implicated in gastrulation regulation. A member of the camello family, NAT-8B contains one N-acetyltransferase domain and is encoded by a gene that maps to human chromosome 2p13.2. The NAT-8B gene is susceptible to a nonsense mutation at Serine 16, which leads to a stop codon and subsequently, a non-functional protein that is truncated in length. Similarly, a nonsense mutation at Glutamine 168 is thought to lead to a non-functional protein, as it causes the N-acetyltransferase to become disrupted. Human chromosome 2 consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstré°‰ syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0948R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0948R-A555
Lokale Artikelnummer::
BOSSBS-0948R-A555
Beschreibung:
Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of GPR56 in the developing brain and binding to GPR56 inhibits neuronal migration and activates the RhoA pathway by coupling GPR56 to GNA13 and possibly GNA12.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10082R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10082R-CY3
Lokale Artikelnummer::
BOSSBS-10082R-CY3
Beschreibung:
No data available.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15587R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15587R-CY7
Lokale Artikelnummer::
BOSSBS-15587R-CY7
Beschreibung:
Lysophosphatidic acid acyltransferases (EC 2,3,1,51) catalyse the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15026R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15026R-HRP
Lokale Artikelnummer::
BOSSBS-15026R-HRP
Beschreibung:
C1orf148
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11455R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11455R-A750
Lokale Artikelnummer::
BOSSBS-11455R-A750
Beschreibung:
Lissencephaly (smooth brain) is an abnormality of brain development characterised by incomplete neuronal migration and a smooth cerebral surface, manifesting as severe mental retardation. Genetic analysis has identified two proteins that are mutated in some cases of lissencephaly, designated lissencephaly-1 protein (LIS1) and doublecortin. LIS1 displays sequence homology to subunits of heterotrimeric G proteins, and doublecortin contains a consensus Abl phosphorylation site. In addition, the DCAMKL1 (doublecortin-like and CAM kinase-like 1) protein shows homology to doublecortin. All three proteins are highly expressed in developing brain and may function together to regulate microtubules involved in neuronal migration. The DCAMKL1 protein encodes a functional kinase that is capable of phosphorylating myelin basic protein and itself, but its kinase activity does not appear to affect its microtubule polymerization activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9006R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9006R-HRP
Lokale Artikelnummer::
BOSSBS-9006R-HRP
Beschreibung:
Adenosine deaminase is an enzyme that is present in most tissues and exists predominantly as a monomer, although in some tissues it is associated with adenosine deaminase-binding protein. Adenosine deaminase degrades extracellular adenosine, which is toxic for lymphocytes. A novel family of growth factors that share sequence similarity to adenosine deaminase has been identified. The cat eye syndrome critical region protein (CECR) family includes CECR1, CECR2, CECR3, CECR4, CECR5, CECR6, CECR7, CECR8 and CECR9. The genes encoding CECR proteins are candidates for Cat Eye Syndrome (CES), a developmental disorder associated with the duplication of a 2 Mb region of 22q11.2. CES is characterized by the combination of coloboma of the iris and anal atresia with fistula, downslanting palpebral fissures, preauricular tags and/or pits, frequent occurrence of heart and renal malformations, and normal or near-normal mental development. CECR family members are widely expressed. Specifically, CECR1 has the highest expression in adult heart, lung, lymphoblasts and placenta. CECR2 is also involved in neurulation and chromatin remodeling. Mutations in the CECR2 gene result in neural tube defects.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13290R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13290R-A488
Lokale Artikelnummer::
BOSSBS-13290R-A488
Beschreibung:
Gene amplification is associated with tumor stage and progression in human gliomas. Several amplified loci are identified and comprise multiple genes. The glioma amplified sequence 41 (GAS41) is an evolutionarily conserved eukaryotic protein found in diverse species. GAS41 is related to the AF-9 and ENL proteins, which are putative transcription factors in some acute leukemias, and interacts with a component of the nuclear matrix, NuMA, in interphase cells. GAS41 has a dotted staining pattern in interphase nuclei and a uniform distribution in mitotic cells. GAS41 is ubiquitously expressed, with the highest levels of expression in human brain. In neuroblastoma, GAS41 is located in the nucleoli, but not in the nucleoplasm. GAS41 also binds to the MLL fusion partner AF10, which is involved in two distinct chromosomal translocations associated with hematologic malignancy. In addition, GAS41 interacts with INI1 (Integrase Interactor), which is a human homologue of the yeast SNF5 protein, a component of the SWI/SNF complex. The GAS41 gene maps to human chromosome 12q13-q15.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13609R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13609R-FITC
Lokale Artikelnummer::
BOSSBS-13609R-FITC
Beschreibung:
Spermatogenesis is the process by which male spermatogonia develop into mature spermatozoa. DAZ (deleted in azoospermia) are RNA-binding proteins that play an essential role in spermatogenesis. DAZ proteins influence the first stages of spermatogenesis and the maintenance of germ cell populations. DAZ proteins (DAZ1, DAZ2, DAZ3, DAZ4 and DAZ5) are encoded by separate genes on chromosome Y, each of which contain an AZFc domain in their coding region. DAZ proteins localize to the nucleus of spermatogonia, but relocate to the cytoplasm during meiosis. DAZ proteins contain an RRM (RNA recognition motif) domain that may regulate mRNA translation by binding to the 3’UTR. Deletions in the genes encoding DAZ proteins may cause azoospermia or oligospermia which can lead to male infertility. DAZ4 (deleted in azoospermia 4), also known as pDP1680 or pDP1681, is a 579 amino acid testis specific protein that contains nine DAZ-like domains and two RNA recognition motifs (RRM). DAZ4 exists as two alternatively spliced isoforms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11712R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11712R-CY7
Lokale Artikelnummer::
BOSSBS-11712R-CY7
Beschreibung:
The charged multivesicular body proteins, commonly designated CHMPs, belong to the vacuolar sorting protein family and function as chromatin-modifying proteins. CHMP1-6 are all components of ESCRT (endosomal sorting complex required for transport) I, II or III complexes. These complexes are crucial for sorting endosomal articles into multivesicular bodies (MVBs), and are also required for the formation of these bodies. CHMP2B, also known as CHMP2.5 or vacuolar protein-sorting-associated protein 2-2, is a 213 amino acid cytosolic protein. Widely expressed in brain, heart, skeletal muscle, small intestine, pancreas, lung, placenta and leukocytes, CHMP2B associates directly with CHMP2A and vps4 for the disassembly of the ESCRT-III complex. Defects in the gene encoding CHMP2B have been shown to cause chromosome 3-linked frontotemporal dementia (FTD3).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3707R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3707R-A647
Lokale Artikelnummer::
BOSSBS-3707R-A647
Beschreibung:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013].
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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